NP_055386.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
hairy/enhancer-of-split related with YRPW motif-like protein
NCBI Official Synonym Full Names
hairy/enhancer-of-split related with YRPW motif-like
NCBI Protein Information
hairy/enhancer-of-split related with YRPW motif-like protein; HRT-3; hHRT3; hHeyL; HEY-like protein; OTTHUMP00000000536; hairy-related transcription factor 3; class B basic helix-loop-helix protein 33; hairy/enhancer-of-split related with YRPW motif 3
UniProt Protein Name
Hairy/enhancer-of-split related with YRPW motif-like protein
UniProt Synonym Protein Names
Class B basic helix-loop-helix protein 33; bHLHb33; Hairy-related transcription factor 3
UniProt Synonym Gene Names
UniProt Entry Name
HEYL_HUMAN
NCBI Summary for HEYL
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq]
UniProt Comments for HEYL
HEYL: Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Belongs to the HEY family.
Chromosomal Location of Human Ortholog: 1p34.3
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; AF-1 domain binding; transcription factor activity; transcription corepressor activity; transcription factor binding
Biological Process: transcription from RNA polymerase II promoter; Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation; negative regulation of transcription, DNA-dependent; glomerulus development; mesenchymal cell development
Research Articles on HEYL
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-HEYL antibody
Diseases associated with anti-HEYL antibody
Organs/Tissues associated with anti-HEYL antibody
|