P00738
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
haptoglobin
NCBI Official Synonym Full Names
haptoglobin
NCBI Official Synonym Symbols
BP; HPA1S; HP2ALPHA2; MGC111141; HP [Similar Products]
NCBI Protein Information
haptoglobin; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, beta polypeptide; haptoglobin, alpha polypeptide
UniProt Protein Name
Haptoglobin
UniProt Entry Name
HPT_HUMAN
NCBI Summary for HP
This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
UniProt Comments for HP
HP: Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes. Defects in HP are the cause of anhaptoglobinemia (AHP). AHP is a condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Belongs to the peptidase S1 family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 16q22.2
Cellular Component: extracellular space; extracellular region
Molecular Function: antioxidant activity; protein binding; hemoglobin binding; catalytic activity
Biological Process: receptor-mediated endocytosis; response to hydrogen peroxide; immune system process; metabolic process; negative regulation of oxidoreductase activity; defense response to bacterium; acute-phase response; defense response
Disease: Anhaptoglobinemia
Research Articles on HP
1. depressed plasma concentrations in women with preeclampsia2. Specific Hp polymorphisms may be associated with cGVHD development and warrant further investigation.3. the influences of the haptoglobin, MnSOD, CAT, GPX1, ACE, glutathione S-transferases M1 (GSTM1) and T1 (GSTT1) genes' polymorphisms on the oxidative stress and damage suffered by human runners was studied4. The results extend previous observations that Hp2-2 is associated with clinical cardiovascular disease in diabetes.5. Haptoglobin may be a potential useful biomarker for diagnosis or a medicine target for treatment of neuromyelitis optica.6. Results suggest an association between haptoglobin (Hp) genotypes and the severity of heart complications in Chagas' disease.7. Our data show that Haptoglobin is a novel monocyte chemoattractant and that its chemotactic potential is mediated, at least in part. by its interaction with CCR2.8. Our results have identified, for the first time, unique patterns of haptoglobin mRNA expression and protein localization in the stromal and glandular epithelial cells of endometrioid adenocarcinoma of the uterus.9. Genetic polymorphisms of SLC2A2 and HP is associated with serum cholesterol levels.10. analysis of the N-glycosylation status of beta-haptoglobin in sera of patients with prostate cancer vs. benign prostate diseases11. Results identified haptoglobin alpha-1, apolipoprotein C-I and apolipoprotein C-III as candidate biomarkers in PTC.12. we have now identified human zonulin as the precursor for haptoglobin-2 (pre-HP2).13. We did not find any association between HP genotypes and type 2 diabetes or the anthropometric and clinical features examined in the population studied.14. under conditions of severe inflammation and oxidative stress, peroxidase activity of Hb-Hp covalent aggregates may cause macrophage dysfunction and microvascular vasoconstriction15. Haptoglobin genotype is closely related to recurrence rate inpatients with HNSCC.16. haptoglobin and serum amyloid A may have roles in atherothrombotic ischemic stroke17. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)18. Meta-analysis of gene-disease association. (HuGE Navigator)19. These results indicate that haptoglobin (Hp)improves endothelial progenitor cells (EPCs) function in neovasculogenesis, which suggests that ex vivo modification of EPCs with the Hp gene can be applied to the treatment of vascular damage.20. HDL can become proinflammatory via the hemoglobin x Hp pathway in mice and humans
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Products associated with anti-HP antibody
Pathways associated with anti-HP antibody
Diseases associated with anti-HP antibody
Organs/Tissues associated with anti-HP antibody
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