AAA52686.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
haptoglobin, partial
NCBI Official Synonym Full Names
haptoglobin-related protein
NCBI Protein Information
haptoglobin-related protein; Haptoglobin-related locus
UniProt Protein Name
Haptoglobin-related protein
UniProt Entry Name
HPTR_HUMAN
NCBI Summary for HPR
This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]
UniProt Comments for HPR
HPR: a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: extracellular region
Molecular Function: hemoglobin binding; catalytic activity
Biological Process: receptor-mediated endocytosis; metabolic process
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Products associated with anti-HPR antibody
Pathways associated with anti-HPR antibody
Diseases associated with anti-HPR antibody
Organs/Tissues associated with anti-HPR antibody
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