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anti-HSPA1L antibody :: Rabbit anti-Human Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2004342 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $105 +1 FREE 8GB USB
0.02 mg  /  $125 +1 FREE 8GB USB
0.05 mg  /  $170 +1 FREE 8GB USB
0.1 mg  /  $220 +1 FREE 8GB USB
0.2 mg  /  $320 +1 FREE 8GB USB
1 mg  /  $760 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Heat Shock 70kDa Protein 1 Like Protein (HSPA1L), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Heat Shock 70kDa Protein 1 Like Protein (HSPA1L)

 Product Gene Name   

anti-HSPA1L antibody

[Similar Products]
 Matching Pairs    Antibody: Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) (MBS2004342)
Antigen: Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) (MBS2009342)
 Matching Pairs    Unconjugated Antibody: Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) (MBS2004342)
Cy3 Conjugated Antibody: Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) (MBS2051094)
 Matching Pairs    Unconjugated Antibody: Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) (MBS2004342)
APC: Immunoglobulin G (MBS2090675)
 Matching Pairs    Unconjugated Antibody: Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) (MBS2004342)
Unconjugated Secondary Antibody: Immunoglobulin G (MBS2090678)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below.
MHHHHHHSSG LVPRGSGMKE TAAAKFERQH MDSPDLGTDD DDKAMADIGS EF- MATAKGIAIG IDLGTTYSCV GVFQHGKVEI IANDQGNRTT PSYVAFTDTE RLIGDAAKNQ VAMNPQNTVF DAKRLIGRKF NDPVVQADMK LWPFQVINEG GKPKVLVSYK GENKAFYPEE ISSMVLTKLK ETAEAFLGHP VTNAVITVPA YFNDSQRQAT KDAGVIAGLN VLRIINEPTA AAIAYGLDKG GQGERHVLIF DLGGGTFDVS ILTIDDGIFE VKATAGDTHL GGEDFDNRLV SHFVEEFKRK HKKDISQNKR AVRRLRTACE RAKRTLSSST QANLEIDSLY EGIDFYTSIT RARFEELCAD LFRGTLEPVE KALRDAKMDK AKIHDIVLVG GSTRIPKVQR LLQDYFNGRD LNKSINPDEA VAYGAAVQAA ILMGDKSEKV QDLLLLDVAP LSLGLETAGG VMTALIKRNS TIPTKQTQIF TTYSDNQPGV LIQVYEGERA MTKDNNLLGR FDLTGIPPAP RGVPQIEVTF DIDANGILNV TATDKSTGKV NKITITNDKG RLSKEEIERM VLDAEKYKAE DEVQREKIAA KNALESYAFN MKSVVSDEGL KGKISESDKN KILDKCNELL SWLEVNQLAE KDEFDHKRKE LEQMCNPIIT KLYQGGCTGP ACGTGYVPGR PATGPTIEEV D
 OMIM    M59829 Genomic DNA
 3D Structure    ModBase 3D Structure for P34931
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against HSPA1L. It has been selected for its ability to recognize HSPA1L in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Immunogen    Recombinant HSPA1L (Met1~Asp641) expressed in E.coli.
 Conjugated Antibody    The Cy3 conjugated antibody version of this item is also available as catalog #MBS2051094
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-HSPA1L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-HSPA1L antibody    Knock-Out Validation Antibody
 Applications Tested/Suitable for anti-HSPA1L antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-HSPA1L antibody    Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
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 Western Blot (WB) Knockout Verification of anti-HSPA1L antibody    Knockout Verification: Lane 1: Wild-type Raji cell lysate; Lane 2: HSPA1L knockout Raji cell lysate; Predicted MW: 70kd Observed MW: 70kd Primary Ab: 5ug/ml Rabbit Anti-Human HSPA1L Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
anti-HSPA1L antibody Western Blot (WB) Knockout Verification (WB) image
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 Western Blot (WB) of anti-HSPA1L antibody    Western Blot; Sample: Human Raji cell lysate; Primary Ab: 5ug/ml Rabbit Anti-Human HSPA1L Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
anti-HSPA1L antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-HSPA1L antibody    Western Blot; Sample: Recombinant protein.
anti-HSPA1L antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-HSPA1L antibody    DAB staining on IHC-P. Samples: Human Tissue)
anti-HSPA1L antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for HSPA1L. It may not necessarily be applicable to this product.
 NCBI GI #    124256496
 NCBI GeneID    3305
 NCBI Accession #    NP_005518.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_005527.3 [Other Products]
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 UniProt Primary Accession #    P34931 [Other Products]
 UniProt Secondary Accession #    O75634; Q2HXR3; Q8NE72; Q96QC9; Q9UQM1; A6NNB0; B0UXW8 [Other Products]
 UniProt Related Accession #    P34931 [Other Products]
 Molecular Weight    70,375 Da
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 NCBI Official Full Name    heat shock 70 kDa protein 1-like
 NCBI Official Synonym Full Names    heat shock protein family A (Hsp70) member 1 like
 NCBI Official Symbol    HSPA1L [Similar Products]
 NCBI Official Synonym Symbols   
HSP70T; hum70t; HSP70-1L; HSP70-HOM
[Similar Products]
 NCBI Protein Information    heat shock 70 kDa protein 1-like
 UniProt Protein Name    Heat shock 70 kDa protein 1-like
 UniProt Synonym Protein Names   
Heat shock 70 kDa protein 1-Hom; HSP70-Hom
 Protein Family    Heat shock 70 kDa protein
 UniProt Gene Name    HSPA1L [Similar Products]
 UniProt Synonym Gene Names    Heat shock 70 kDa protein 1L; HSP70-Hom [Similar Products]
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 NCBI Summary for HSPA1L    This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HSPA1L    HSPA1L: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. Not induced by heat shock. Expressed in spermatids. Belongs to the heat shock protein 70 family.

Protein type: Chaperone; Heat shock protein; Mitochondrial

Chromosomal Location of Human Ortholog: 6p21.33

Cellular Component: cytosol; mitochondrial matrix; nucleoplasm; signalosome

Molecular Function: ATP binding; heat shock protein binding; protein binding; ubiquitin protein ligase binding; unfolded protein binding

Biological Process: binding of sperm to zona pellucida; protein refolding; response to unfolded protein
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 Research Articles on HSPA1L    1. This is the first study to show that HSPA1L mediated HIF-1alpha stabilization. In addition, this is the first study to show that GP78 inactivation promotes cancer cell proliferation, migration and eventual tumor growth both in vivo and in vitro by increasing cellular prion protein.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-HSPA1L antibodyDiseases associated with anti-HSPA1L antibody
 Products by Pathway  Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >5 publications with HSPA1L and Cardiovascular Diseases
 Neoplasms Antibodies  >4 publications with HSPA1L and Neoplasms
 Necrosis Antibodies  >4 publications with HSPA1L and Necrosis
 Inflammation Antibodies  >3 publications with HSPA1L and Inflammation
 Lung Diseases Antibodies  >3 publications with HSPA1L and Lung Diseases
 Drug Hypersensitivity Antibodies  >3 publications with HSPA1L and Drug Hypersensitivity
 Heart Diseases Antibodies  >2 publications with HSPA1L and Heart Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with HSPA1L and Carcinoma, Hepatocellular
 Drug Toxicity Antibodies  >2 publications with HSPA1L and Drug Toxicity
 Hypertension Antibodies  >1 publications with HSPA1L and Hypertension
Organs/Tissues associated with anti-HSPA1L antibody
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >2 publications with HSPA1L and Testis
 Kidney Antibodies  >1 publications with HSPA1L and Kidney
 Lung Antibodies  >1 publications with HSPA1L and Lung
 Eye Antibodies  >1 publications with HSPA1L and Eye
 Connective Tissue Antibodies  >1 publications with HSPA1L and Connective Tissue
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