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anti-HSP90B antibody :: Rabbit anti-Human Heat shock protein HSP 90-beta Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1499004
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Heat shock protein HSP 90-beta (HSP90B), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Heat shock protein HSP 90-beta polyclonal Antibody

 Product Synonym Names    HSP 90; Heat shock 84 kDa; HSP 84; HSP90AB1; HSPC2; HSPCB
 Product Gene Name   

anti-HSP90B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    140572
 3D Structure    ModBase 3D Structure for P08238
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Non-conjugated
 Immunogen    Recombinant human human Heat shock protein HSP 90-beta protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1057
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-HSP90B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HSP90B antibody

   Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.
 Applications Tested/Suitable for anti-HSP90B antibody   

ELISA (EIA), Western Blot (WB)

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 Western Blot (WB) of anti-HSP90B antibody    Western blot
All lanes: Hsp90ab1antibody at 2ug/ml
Lane 1: Mouse lung tissue
Lane 2: Rat lung tissue
Lane 3: Zebrafish lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/10000 dilution
Predicted band size: 83 kDa
Observed band size: 83,120,32 kDa

anti-HSP90B antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-HSP90B antibody    Western Blot
Positive WB detected in: hepG2 cell
All lanes: CHD4 antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 83 kDa
Observed band size: 83 kDa

anti-HSP90B antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-HSP90B antibody    Western Blot
Positive WB detected in: K562 whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate
All lanes: HSP90AB1 antibody at 2ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 84 KDa
Observed band size: 84 KDa

anti-HSP90B antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-HSP90B antibody    IHC image of MBS1499004 diluted at 1:200 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 degree C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
anti-HSP90B antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-HSP90B antibody    Immunofluorescence staining of MCF-7 cells with MBS1499004 at 1:66,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4 degree C.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
anti-HSP90B antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for HSP90B. It may not necessarily be applicable to this product.
 NCBI GI #    431822401
 NCBI GeneID    3326
 NCBI Accession #    NP_001258898.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001271969.1 [Other Products]
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 UniProt Primary Accession #    P08238 [Other Products]
 UniProt Secondary Accession #    Q5T9W7; Q9NQW0; Q9NTK6; B2R5P0 [Other Products]
 UniProt Related Accession #    P08238 [Other Products]
 Molecular Weight    83,264 Da
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 NCBI Official Full Name    heat shock protein HSP 90-beta isoform a
 NCBI Official Synonym Full Names    heat shock protein 90kDa alpha family class B member 1
 NCBI Official Symbol    HSP90AB1 [Similar Products]
 NCBI Official Synonym Symbols   
HSP84; HSPC2; HSPCB; D6S182; HSP90B
[Similar Products]
 NCBI Protein Information    heat shock protein HSP 90-beta
 UniProt Protein Name    Heat shock protein HSP 90-beta
 UniProt Synonym Protein Names   
Heat shock 84 kDa; HSP 84; HSP84
 Protein Family    Heat shock protein
 UniProt Gene Name    HSP90AB1 [Similar Products]
 UniProt Synonym Gene Names    HSP90B; HSPC2; HSPCB; HSP 90; HSP 84; HSP84 [Similar Products]
 UniProt Entry Name    HS90B_HUMAN
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 NCBI Summary for HSP90B    This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]
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 UniProt Comments for HSP90B    HSP90B: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Homodimer. Interacts with p53/TP53. Forms a complex with CDK6 and Hsp90/HSP90AB1. Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer. Interacts with CHORDC1 and DNAJC7. Interacts with FKBP4. Belongs to the heat shock protein 90 family.

Protein type: Heat shock protein; Chaperone

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: apical plasma membrane; basolateral plasma membrane; brush border membrane; cell surface; cytoplasm; cytosol; inclusion body; melanosome; membrane; mitochondrion; nucleoplasm; signalosome

Molecular Function: ATP binding; dATP binding; double-stranded RNA binding; GTP binding; histone deacetylase binding; kinase binding; nitric-oxide synthase regulator activity; protein binding; protein kinase binding; sulfonylurea receptor binding; TPR domain binding; unfolded protein binding

Biological Process: axon guidance; innate immune response; negative regulation of neuron apoptosis; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; placenta development; positive regulation of cell size; positive regulation of nitric oxide biosynthetic process; positive regulation of protein binding; positive regulation of protein import into nucleus, translocation; protein folding; regulation of protein ubiquitination; response to salt stress; response to unfolded protein; virion attachment to host cell surface receptor
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 Research Articles on HSP90B    1. These results suggest a means by which the hsp90beta interaction could prevent apo-sGCbeta1 from associating with its partner sGCalpha1 subunit while enabling structural changes to assist heme insertion into the H-NOX domain.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HSP90B antibodyPathways associated with anti-HSP90B antibody
 Reference Product  PubMed Publications
 HSP90AA1 antibody  >14 publications with HSP90B and HSP90AA1
 CDC37 antibody  >3 publications with HSP90B and CDC37
 Products by Pathway  Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Attenuation Phase Pathway antibodies  Attenuation Phase Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cellular Response To Heat Stress Pathway antibodies  Cellular Response To Heat Stress Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
Diseases associated with anti-HSP90B antibodyOrgans/Tissues associated with anti-HSP90B antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >8 publications with HSP90B and Nervous System Diseases
 Inflammation Antibodies  >6 publications with HSP90B and Inflammation
 Lung Neoplasms Antibodies  >5 publications with HSP90B and Lung Neoplasms
 Necrosis Antibodies  >4 publications with HSP90B and Necrosis
 Breast Neoplasms Antibodies  >4 publications with HSP90B and Breast Neoplasms
 Infertility, Male Antibodies  >3 publications with HSP90B and Infertility, Male
 Liver Neoplasms Antibodies  >3 publications with HSP90B and Liver Neoplasms
 Liver Diseases Antibodies  >3 publications with HSP90B and Liver Diseases
 Disease Models, Animal Antibodies  >3 publications with HSP90B and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >2 publications with HSP90B and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >14 publications with HSP90B and Blood
 Lung Antibodies  >11 publications with HSP90B and Lung
 Brain Antibodies  >7 publications with HSP90B and Brain
 Intestine Antibodies  >5 publications with HSP90B and Intestine
 Vascular Antibodies  >5 publications with HSP90B and Vascular
 Ovary Antibodies  >5 publications with HSP90B and Ovary
 Liver Antibodies  >4 publications with HSP90B and Liver
 Embryonic Tissue Antibodies  >4 publications with HSP90B and Embryonic Tissue
 Testis Antibodies  >4 publications with HSP90B and Testis
 Kidney Antibodies  >4 publications with HSP90B and Kidney
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