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anti-HCK antibody :: Rabbit anti-Mouse Hemopoietic Cell Kinase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2026020 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.02 mg  /  $130 +1 FREE 8GB USB
0.05 mg  /  $185 +1 FREE 8GB USB
0.1 mg  /  $230 +1 FREE 8GB USB
0.2 mg  /  $345 +1 FREE 8GB USB
1 mg  /  $825 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Hemopoietic Cell Kinase (HCK), Polyclonal Antibody

 Also Known As   

Polyclonal Antibody to Hemopoietic Cell Kinase (HCK)

 Product Gene Name   

anti-HCK antibody

[Similar Products]
 Matching Pairs    Antibody: Hemopoietic Cell Kinase (MBS2026020)
Antigen: Hemopoietic (MBS2030323)
 Matching Pairs    Unconjugated Antibody: Hemopoietic Cell Kinase (MBS2026020)
APC-CY7 Conjugated Antibody: Hemopoietic Cell Kinase (HCK) (MBS2066406)
 Matching Pairs    Unconjugated Antibody: Hemopoietic Cell Kinase (MBS2026020)
PE Conjugated Antibody: Hemopoietic Cell Kinase (HCK) (MBS2066407)
 Matching Pairs    Unconjugated Antibody: Hemopoietic Cell Kinase (MBS2026020)
APC-CY7 Conjugated Antibody: Hemopoietic Cell Kinase (HCK) (MBS2066408)
 Matching Pairs    Unconjugated Antibody: Hemopoietic Cell Kinase (MBS2026020)
Cy3 Conjugated Antibody: Hemopoietic Cell Kinase (HCK) (MBS2066409)
 Matching Pairs    Unconjugated Antibody: Hemopoietic Cell Kinase (MBS2026020)
FITC Conjugated Antibody: Hemopoietic Cell Kinase (HCK) (MBS2066410)
 Matching Pairs    Unconjugated Antibody: Hemopoietic Cell Kinase (MBS2026020)
HRP Conjugated Antibody: Hemopoietic Cell Kinase (HCK) (MBS2066411)
 Matching Pairs    Unconjugated Antibody: Hemopoietic Cell Kinase (MBS2026020)
APC-CY7 Conjugated Secondary Antibody: Immunoglobulin G (MBS2090675)
 Matching Pairs    Unconjugated Antibody: Hemopoietic Cell Kinase (MBS2026020)
Unconjugated Secondary Antibody: Immunoglobulin G (MBS2090678)
 Matching Pairs    Unconjugated Antibody: Hemopoietic Cell Kinase (MBS2026020)
Biotin Conjugated Antibody: Hemopoietic Cell Kinase (HCK) (MBS2094614)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P08103
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse
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 Specificity    The antibody is a rabbit polyclonal antibody raised against HCK. It has beenselected for its ability to recognize HCK in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Liquid
 Concentration    200ug/ml (lot specific)
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 Fragment    HCK (Gly2~Pro524)
 Organism Species    Mus musculus (Mouse)
 Conjugate    No Conjugate
 Immunogen    Recombinant HCK (Gly2~Pro524) expressed in E Coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2066408
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-HCK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-HCK antibody   

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)

 Application Notes for anti-HCK antibody    Western blotting: 0.2-2ug/mL;1:250-2500
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.
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 Western Blot (WB) of anti-HCK antibody    (Figure. Western Blot; Sample: Recombinant protein.)
anti-HCK antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-HCK antibody    (Used in DAB staining on formalin fixed paraffin- embedded Kidney tissue)
anti-HCK antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for HCK. It may not necessarily be applicable to this product.
 NCBI GI #    287323109
 NCBI GeneID    15162
 NCBI Accession #    NP_001165588.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001172117.1 [Other Products]
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 UniProt Primary Accession #    P08103 [Other Products]
 UniProt Secondary Accession #    Q0VH03; Q3UD17 [Other Products]
 UniProt Related Accession #    P08103 [Other Products]
 Molecular Weight    56,942 Da
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 NCBI Official Full Name    tyrosine-protein kinase HCK isoform p56Hck
 NCBI Official Synonym Full Names    hemopoietic cell kinase
 NCBI Official Symbol    Hck [Similar Products]
 NCBI Official Synonym Symbols   
Bmk; AI849071
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase HCK
 UniProt Protein Name    Tyrosine-protein kinase HCK
 UniProt Synonym Protein Names   
B-cell/myeloid kinase; BMK; Hematopoietic cell kinase; Hemopoietic cell kinase; p56-HCK/p59-HCK
 Protein Family    Tyrosine-protein kinase
 UniProt Gene Name    Hck [Similar Products]
 UniProt Synonym Gene Names    BMK [Similar Products]
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 NCBI Summary for HCK    The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may play a role in the innate immune response and the STAT5 signaling pathway. Alternative translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization. [provided by RefSeq, Feb 2010]
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 UniProt Comments for HCK    Hck: a protein-tyrosine kinase of the Src family that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms that have different subcellular localization.

Protein type: EC 2.7.10.2; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group

Chromosomal Location of Human Ortholog: 2 H1|2 75.41 cM

Cellular Component: actin filament; caveola; cell junction; cell projection; cytoplasm; cytoplasmic vesicle; cytoskeleton; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; Golgi apparatus; lysosome; membrane; nucleoplasm; nucleus; plasma membrane

Molecular Function: ATP binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphotyrosine binding; protein binding; protein kinase activity; protein tyrosine kinase activity; receptor binding; transferase activity

Biological Process: cell differentiation; cell migration; defense response to Gram-positive bacterium; exocytosis; immune system process; inflammatory response; innate immune response; negative regulation of apoptosis; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phagocytosis; phosphorylation; positive regulation of actin cytoskeleton reorganization; positive regulation of cell proliferation; protein amino acid phosphorylation; protein autophosphorylation; regulation of cell proliferation; regulation of cell shape; regulation of phagocytosis; regulation of podosome assembly; regulation of transcription factor activity; transmembrane receptor protein tyrosine kinase signaling pathway
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 Research Articles on HCK    1. the Hck, Fgr and Lyn kinases are also necessary for amastigote uptake by macrophages. Src-mediated Arg activation is required for efficient uptake.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-HCK antibodyDiseases associated with anti-HCK antibody
 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 FCGR Activation Pathway antibodies  FCGR Activation Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies  Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >32 publications with HCK and Inflammation
 Necrosis Antibodies  >29 publications with HCK and Necrosis
 Carcinoma Antibodies  >22 publications with HCK and Carcinoma
 Lung Diseases Antibodies  >10 publications with HCK and Lung Diseases
 Kidney Diseases Antibodies  >9 publications with HCK and Kidney Diseases
 Neoplasms, Experimental Antibodies  >7 publications with HCK and Neoplasms, Experimental
 Vascular Diseases Antibodies  >7 publications with HCK and Vascular Diseases
 Brain Diseases Antibodies  >7 publications with HCK and Brain Diseases
 Cardiovascular Diseases Antibodies  >6 publications with HCK and Cardiovascular Diseases
 Precursor Cell Lymphoblastic Leukemia-Lymphoma Antibodies  >5 publications with HCK and Precursor Cell Lymphoblastic Leukemia-Lymphoma
Organs/Tissues associated with anti-HCK antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >42 publications with HCK and Bone
 Bone Marrow Antibodies  >36 publications with HCK and Bone Marrow
 Lung Antibodies  >22 publications with HCK and Lung
 Kidney Antibodies  >16 publications with HCK and Kidney
 Eye Antibodies  >15 publications with HCK and Eye
 Spleen Antibodies  >15 publications with HCK and Spleen
 Brain Antibodies  >10 publications with HCK and Brain
 Pancreas Antibodies  >3 publications with HCK and Pancreas
 Thymus Antibodies  >3 publications with HCK and Thymus
 Embryonic Tissue Antibodies  >3 publications with HCK and Embryonic Tissue
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