NP_002989.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
syndecan-2
NCBI Official Synonym Full Names
syndecan 2
NCBI Protein Information
syndecan-2
UniProt Protein Name
Syndecan-2
UniProt Synonym Protein Names
Fibroglycan; Heparan sulfate proteoglycan core protein; HSPG; CD_antigen: CD362
UniProt Synonym Gene Names
NCBI Summary for HSPG
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]
UniProt Comments for HSPG
syndecan-2: a heparan sulfate proteoglycan type I membrane protein that belongs to the syndecan proteoglycan family. Preferentially expressed in cells of mesenchymal origin. Is tyrosine phosphorylated and forms a complex with EphB2 in mouse brain. Plays a role in mediating adhesion and proliferation of colon carcinoma cells.
Protein type: Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8q22.1
Cellular Component: cell surface; endoplasmic reticulum lumen; extracellular matrix; Golgi lumen; integral component of membrane; lysosomal lumen; plasma membrane
Molecular Function: identical protein binding; PDZ domain binding; protein binding
Biological Process: bioluminescence; cell migration; cellular protein metabolic process; dendrite morphogenesis; ephrin receptor signaling pathway; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; glycosaminoglycan metabolic process; leukocyte migration; post-translational protein modification; regulation of dendrite morphogenesis; retinoid metabolic process
Research Articles on HSPG
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Products associated with anti-HSPG antibody
Pathways associated with anti-HSPG antibody
Diseases associated with anti-HSPG antibody
Organs/Tissues associated with anti-HSPG antibody
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