NP_116171.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
hepatitis A virus cellular receptor 2
NCBI Official Synonym Full Names
hepatitis A virus cellular receptor 2
NCBI Official Synonym Symbols
TIM3; CD366; KIM-3; TIMD3; Tim-3; TIMD-3; HAVcr-2 [Similar Products]
NCBI Protein Information
hepatitis A virus cellular receptor 2
UniProt Protein Name
Hepatitis A virus cellular receptor 2
UniProt Synonym Protein Names
T-cell immunoglobulin and mucin domain-containing protein 3; TIMD-3; T-cell immunoglobulin mucin receptor 3; TIM-3; T-cell membrane protein 3
UniProt Synonym Gene Names
UniProt Entry Name
HAVR2_HUMAN
NCBI Summary for HAVCR2
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]
UniProt Comments for HAVCR2
TIM-3: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9. Belongs to the immunoglobulin superfamily. TIM family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 5q33.3
Cellular Component: cell surface; integral to membrane
Biological Process: inhibition of NF-kappaB transcription factor; maternal process involved in pregnancy; natural killer cell tolerance induction; negative regulation of interferon-alpha production; negative regulation of interferon-gamma production; negative regulation of interleukin-2 production; negative regulation of interleukin-3 production; negative regulation of myeloid dendritic cell activation; negative regulation of tumor necrosis factor production; positive regulation of chemokine production; positive regulation of innate immune response; positive regulation of interleukin-1 production; positive regulation of interleukin-4 production; positive regulation of macrophage activation
Disease: Rheumatoid Arthritis
Research Articles on HAVCR2
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Products associated with anti-HAVCR2 antibody
Pathways associated with anti-HAVCR2 antibody
Diseases associated with anti-HAVCR2 antibody
Organs/Tissues associated with anti-HAVCR2 antibody
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