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anti-HAVCR2 antibody :: Rabbit anti-Human Hepatitis A virus cellular receptor 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7004309
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Hepatitis A virus cellular receptor 2 (HAVCR2), Polyclonal Antibody

 Also Known As   

Rabbit anti-human Hepatitis A virus cellular receptor 2 polyclonal Antibody

 Product Synonym Names    T-cell immunoglobulin and mucin domain-containing protein 3; T-cell membrane protein 3; TIM-3; HAVCR2; TIM3; TIMD3
 Product Gene Name   

anti-HAVCR2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606652
 3D Structure    ModBase 3D Structure for Q8TDQ0
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Hepatitis A virus cellular receptor 2 protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-30325 / sc-30326 / sc-292389
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-HAVCR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-HAVCR2 antibody

   Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.
 Product Categories/Family for anti-HAVCR2 antibody    Immunology
 Applications Tested/Suitable for anti-HAVCR2 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-HAVCR2 antibody    Recommended dilution: IHC: 1:20-1:200
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 Immunohistochemistry (IHC) of anti-HAVCR2 antibody    Immunohistochemistry of paraffin-embedded mouseidney at dilution 1:50
anti-HAVCR2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-HAVCR2 antibody    Immunofluorescent analysis of MCF-7 cells at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-HAVCR2 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for HAVCR2. It may not necessarily be applicable to this product.
 NCBI GI #    49574534
 NCBI GeneID    84868
 NCBI Accession #    NP_116171.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_032782.4 [Other Products]
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 UniProt Primary Accession #    Q8TDQ0 [Other Products]
 UniProt Secondary Accession #    Q8WW60; Q96K94; B2RAY2 [Other Products]
 UniProt Related Accession #    Q8TDQ0 [Other Products]
 Molecular Weight    16,149 Da
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 NCBI Official Full Name    hepatitis A virus cellular receptor 2
 NCBI Official Synonym Full Names    hepatitis A virus cellular receptor 2
 NCBI Official Symbol    HAVCR2 [Similar Products]
 NCBI Official Synonym Symbols   
TIM3; CD366; KIM-3; TIMD3; Tim-3; TIMD-3; HAVcr-2
[Similar Products]
 NCBI Protein Information    hepatitis A virus cellular receptor 2
 UniProt Protein Name    Hepatitis A virus cellular receptor 2
 UniProt Synonym Protein Names   
T-cell immunoglobulin and mucin domain-containing protein 3; TIMD-3; T-cell immunoglobulin mucin receptor 3; TIM-3; T-cell membrane protein 3
 Protein Family    Hepatitis A virus cellular receptor
 UniProt Gene Name    HAVCR2 [Similar Products]
 UniProt Synonym Gene Names    TIM3; TIMD3; HAVcr-2; TIMD-3; TIM-3 [Similar Products]
 UniProt Entry Name    HAVR2_HUMAN
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 NCBI Summary for HAVCR2    The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]
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 UniProt Comments for HAVCR2    TIM-3: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9. Belongs to the immunoglobulin superfamily. TIM family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q33.3

Cellular Component: cell surface; integral to membrane

Biological Process: inhibition of NF-kappaB transcription factor; maternal process involved in pregnancy; natural killer cell tolerance induction; negative regulation of interferon-alpha production; negative regulation of interferon-gamma production; negative regulation of interleukin-2 production; negative regulation of interleukin-3 production; negative regulation of myeloid dendritic cell activation; negative regulation of tumor necrosis factor production; positive regulation of chemokine production; positive regulation of innate immune response; positive regulation of interleukin-1 production; positive regulation of interleukin-4 production; positive regulation of macrophage activation

Disease: Rheumatoid Arthritis
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 Research Articles on HAVCR2    1. Findings underline the important roles of Tim-3 and PD-1 pathways in regulating decidual CD8+ T-cell function and maintaining normal pregnancy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HAVCR2 antibodyPathways associated with anti-HAVCR2 antibody
 Reference Product  PubMed Publications
 CD4 antibody  >138 publications with HAVCR2 and CD4
 LGALS9 antibody  >57 publications with HAVCR2 and LGALS9
 CTLA4 antibody  >18 publications with HAVCR2 and CTLA4
 LAG3 antibody  >4 publications with HAVCR2 and LAG3
 IL2 antibody  >4 publications with HAVCR2 and IL2
 BAG6 antibody  >3 publications with HAVCR2 and BAG6
 LCK antibody  >1 publications with HAVCR2 and LCK
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-2 Signaling Pathway antibodies  Interleukin-2 Signaling Pathway Diagram
 Signaling By Interleukins Pathway antibodies  Signaling By Interleukins Pathway Diagram
Diseases associated with anti-HAVCR2 antibodyOrgans/Tissues associated with anti-HAVCR2 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >66 publications with HAVCR2 and Inflammation
 Disease Models, Animal Antibodies  >52 publications with HAVCR2 and Disease Models, Animal
 Liver Diseases Antibodies  >38 publications with HAVCR2 and Liver Diseases
 Lung Diseases Antibodies  >35 publications with HAVCR2 and Lung Diseases
 Necrosis Antibodies  >34 publications with HAVCR2 and Necrosis
 Asthma Antibodies  >23 publications with HAVCR2 and Asthma
 Respiratory Hypersensitivity Antibodies  >21 publications with HAVCR2 and Respiratory Hypersensitivity
 Neoplasms, Experimental Antibodies  >20 publications with HAVCR2 and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >17 publications with HAVCR2 and Cardiovascular Diseases
 Skin Diseases Antibodies  >16 publications with HAVCR2 and Skin Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >295 publications with HAVCR2 and Blood
 Liver Antibodies  >33 publications with HAVCR2 and Liver
 Spleen Antibodies  >24 publications with HAVCR2 and Spleen
 Lung Antibodies  >18 publications with HAVCR2 and Lung
 Kidney Antibodies  >14 publications with HAVCR2 and Kidney
 Bone Marrow Antibodies  >14 publications with HAVCR2 and Bone Marrow
 Heart Antibodies  >9 publications with HAVCR2 and Heart
 Brain Antibodies  >8 publications with HAVCR2 and Brain
 Intestine Antibodies  >5 publications with HAVCR2 and Intestine
 Placenta Antibodies  >4 publications with HAVCR2 and Placenta
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