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anti-HGFR antibody :: Rabbit anti-Human Hepatocyte Growth Factor Receptor Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2025962 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.02 mg  /  $130 +1 FREE 8GB USB
0.05 mg  /  $175 +1 FREE 8GB USB
0.1 mg  /  $225 +1 FREE 8GB USB
0.2 mg  /  $340 +1 FREE 8GB USB
1 mg  /  $800 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Hepatocyte Growth Factor Receptor (HGFR), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Hepatocyte Growth Factor Receptor (HGFR)

 Product Gene Name   

anti-HGFR antibody

[Similar Products]
 Matching Pairs    Antibody: Hepatocyte Growth Factor Receptor (MBS2025962)
Antigen: Hepatocyte Growth Factor (MBS2031090)
 Matching Pairs    Unconjugated Antibody: Hepatocyte Growth Factor Receptor (MBS2025962)
APC-CY7 Conjugated Antibody: Hepatocyte Growth Factor Receptor (HGFR) (MBS2063851)
 Matching Pairs    Unconjugated Antibody: Hepatocyte Growth Factor Receptor (MBS2025962)
PE Conjugated Antibody: Hepatocyte Growth Factor Receptor (HGFR) (MBS2063852)
 Matching Pairs    Unconjugated Antibody: Hepatocyte Growth Factor Receptor (MBS2025962)
APC-CY7 Conjugated Antibody: Hepatocyte Growth Factor Receptor (HGFR) (MBS2063853)
 Matching Pairs    Unconjugated Antibody: Hepatocyte Growth Factor Receptor (MBS2025962)
Cy3 Conjugated Antibody: Hepatocyte Growth Factor Receptor (HGFR) (MBS2063854)
 Matching Pairs    Unconjugated Antibody: Hepatocyte Growth Factor Receptor (MBS2025962)
FITC Conjugated Antibody: Hepatocyte Growth Factor Receptor (HGFR) (MBS2063855)
 Matching Pairs    Unconjugated Antibody: Hepatocyte Growth Factor Receptor (MBS2025962)
HRP Conjugated Antibody: Hepatocyte Growth Factor Receptor (HGFR) (MBS2063856)
 Matching Pairs    Unconjugated Antibody: Hepatocyte Growth Factor Receptor (MBS2025962)
APC-CY7 Conjugated Secondary Antibody: Immunoglobulin G (MBS2090675)
 Matching Pairs    Unconjugated Antibody: Hepatocyte Growth Factor Receptor (MBS2025962)
Unconjugated Secondary Antibody: Immunoglobulin G (MBS2090678)
 Matching Pairs    Unconjugated Antibody: Hepatocyte Growth Factor Receptor (MBS2025962)
Biotin Conjugated Antibody: Hepatocyte Growth Factor Receptor (HGFR) (MBS2094263)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below.
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- VYHGTLLDN DGKKIHCAVK SLNRITDIGE VSQFLTEGII MKDFSHPNVL SLLGICLRSE GSPLVVLPYM KHGDLRNFIR NETHNPTVKD LIGFGLQVAK GMKYLASKKF VHRDLAARNC MLDEKFTVKV ADFGLARDMY DKEYYSVHNK TGAKLPVKWM ALESLQTQKF TTKSDVWSFG VLLWELMTRG APPYPDVNTF DITVYLLQGR RLLQPEYCPD PLYEVMLKCW HPKAEMRPSF SELVSRISAI FSTFIGEHYV
 OMIM    J02958 mRNA
 3D Structure    ModBase 3D Structure for P08581
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against HGFR. It has beenselected for its ability to recognize HGFR in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Liquid
 Concentration    200ug/ml (lot specific)
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 Fragment    HGFR (Val1092~Val1379)
 Organism Species    Homo sapiens (Human)
 Conjugate    No Conjugate
 Immunogen    Recombinant HGFR (Val1092~Val1379) expressed in E Coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2063853
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-HGFR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-HGFR antibody   

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)

 Application Notes for anti-HGFR antibody    Western blotting: 0.5-2ug/mL;1:250-1100
Immunohistochemistry: 5-20ug/mL;1:25-110
Immunocytochemistry: 5-20ug/mL;1:25-110
Optimal working dilutions must be determined by end user.
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 Western Blot (WB) of anti-HGFR antibody    (Figure. Western Blot; Sample: Recombinant HGFR, Human.)
anti-HGFR antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-HGFR antibody    (Figure. DAB staining on IHC-P; Samples: Human Kidney Tissue.)
anti-HGFR antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-HGFR antibody    (Figure. DAB staining on IHC-P; Samples: Human Lung Cancer Tissue.)
anti-HGFR antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for HGFR. It may not necessarily be applicable to this product.
 NCBI GI #    42741655
 NCBI GeneID    4233
 NCBI Accession #    NP_000236.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000245.3 [Other Products]
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 UniProt Primary Accession #    P08581 [Other Products]
 UniProt Secondary Accession #    O60366; Q12875; Q9UDX7; Q9UPL8; A1L467; B5A932; E7EQ94 [Other Products]
 UniProt Related Accession #    P08581 [Other Products]
 Molecular Weight    85,745 Da
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 NCBI Official Full Name    hepatocyte growth factor receptor isoform b preproprotein
 NCBI Official Synonym Full Names    MET proto-oncogene, receptor tyrosine kinase
 NCBI Official Symbol    MET [Similar Products]
 NCBI Official Synonym Symbols   
HGFR; AUTS9; RCCP2; c-Met; DFNB97
[Similar Products]
 NCBI Protein Information    hepatocyte growth factor receptor
 UniProt Protein Name    Hepatocyte growth factor receptor
 UniProt Synonym Protein Names   
HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met
 Protein Family    Hepatocyte growth factor receptor
 UniProt Gene Name    MET [Similar Products]
 UniProt Synonym Gene Names    HGF receptor; SF receptor [Similar Products]
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 NCBI Summary for HGFR    This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
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 UniProt Comments for HGFR    Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis ().
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 Research Articles on HGFR    1. Selective MET tyrosine kinase inhibitor SAR125844 has significant antitumour activity in patients with MET-amplified non-small cell lung carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HGFR antibodyPathways associated with anti-HGFR antibody
 Reference Product  PubMed Publications
 HGF antibody  >2386 publications with HGFR and HGF
 EGFR antibody  >673 publications with HGFR and EGFR
 SRC antibody  >334 publications with HGFR and SRC
 CTNNB1 antibody  >169 publications with HGFR and CTNNB1
 CASP3 antibody  >126 publications with HGFR and CASP3
 GRB2 antibody  >114 publications with HGFR and GRB2
 STAT3 antibody  >111 publications with HGFR and STAT3
 FAS antibody  >101 publications with HGFR and FAS
 GAB1 antibody  >89 publications with HGFR and GAB1
 CBL antibody  >57 publications with HGFR and CBL
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
Diseases associated with anti-HGFR antibodyOrgans/Tissues associated with anti-HGFR antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >11182 publications with HGFR and Neoplasms
 Cardiovascular Diseases Antibodies  >7631 publications with HGFR and Cardiovascular Diseases
 Carcinoma Antibodies  >3779 publications with HGFR and Carcinoma
 Inflammation Antibodies  >1977 publications with HGFR and Inflammation
 Liver Diseases Antibodies  >1730 publications with HGFR and Liver Diseases
 Adenocarcinoma Antibodies  >1714 publications with HGFR and Adenocarcinoma
 Schizophrenia Antibodies  >1585 publications with HGFR and Schizophrenia
 Kidney Diseases Antibodies  >1519 publications with HGFR and Kidney Diseases
 Breast Neoplasms Antibodies  >1448 publications with HGFR and Breast Neoplasms
 Myocardial Infarction Antibodies  >1221 publications with HGFR and Myocardial Infarction
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7678 publications with HGFR and Brain
 Heart Antibodies  >4969 publications with HGFR and Heart
 Bone Antibodies  >3817 publications with HGFR and Bone
 Lung Antibodies  >3519 publications with HGFR and Lung
 Vascular Antibodies  >3483 publications with HGFR and Vascular
 Liver Antibodies  >3482 publications with HGFR and Liver
 Muscle Antibodies  >3372 publications with HGFR and Muscle
 Kidney Antibodies  >2456 publications with HGFR and Kidney
 Skin Antibodies  >1973 publications with HGFR and Skin
 Eye Antibodies  >1541 publications with HGFR and Eye
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