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anti-HRH2 antibody :: Rabbit Histamine H2 Receptor Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS820672
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Histamine H2 Receptor (HRH2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-Histamine H2 Receptor Antibody

 Product Synonym Names    Histamine H2 receptor; H2R; HH2R; Gastric receptor I
 Product Gene Name   

anti-HRH2 antibody

[Similar Products]
 Antibody/Peptide Pairs    Histamine H2 Receptor peptide (MBS824383) is used for blocking the activity of Histamine H2 Receptor antibody (MBS820672)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P25021
 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Recognizes endogenous levels of Histamine H2 Receptor protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Histamine H2 Receptor. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4C. Upon delivery aliquot and store at -20C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-HRH2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HRH2 antibody

   Rabbit polyclonal antibody to Histamine H2 Receptor
 Applications Tested/Suitable for anti-HRH2 antibody   


 Application Notes for anti-HRH2 antibody    WB (1/500 - 1/1000)
IF/IC(1/100 - 1/500)
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 Western Blot (WB) of anti-HRH2 antibody    Western blot analysis of Histamine H2 Receptor expression in HEK293T (A), COLO205 (B), NIH3T3 (C), H9C2 (D) whole cell lysates.
anti-HRH2 antibody Western Blot (WB) (WB) image
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 Immunofluorescence of anti-HRH2 antibody    Immunofluorescent analysis of Histamine H2 Receptor staining in COLO205 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
anti-HRH2 antibody Immunofluorescence image
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NCBI/Uniprot data below describe general gene information for HRH2. It may not necessarily be applicable to this product.
 NCBI GI #    197085610
 NCBI GeneID    3274
 NCBI Accession #    NP_001124527.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001131055.1 [Other Products]
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 UniProt Primary Accession #    P25021 [Other Products]
 UniProt Secondary Accession #    Q9D282 [Other Products]
 UniProt Related Accession #    P25021 [Other Products]
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 NCBI Official Full Name    histamine H2 receptor isoform 1
 NCBI Official Synonym Full Names    histamine receptor H2
 NCBI Official Symbol    HRH2 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    histamine H2 receptor; HH2R; gastric receptor 1; gastric receptor I
 UniProt Protein Name    Histamine H2 receptor
 UniProt Synonym Protein Names   
Gastric receptor I
 Protein Family    Histamine H2 receptor
 UniProt Gene Name    Hrh2 [Similar Products]
 UniProt Synonym Gene Names    H2R; HH2R [Similar Products]
 UniProt Entry Name    HRH2_MOUSE
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 NCBI Summary for HRH2    Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
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 UniProt Comments for HRH2    H2R: The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q35.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: histamine receptor activity

Biological Process: gland development; G-protein signaling, coupled to cyclic nucleotide second messenger; gastrin-induced gastric acid secretion; gut development; histamine-induced gastric acid secretion; positive regulation of vasoconstriction; visual learning; regulation of synaptic plasticity; immune response; memory
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 Research Articles on HRH2    1. But carriers of one or three copies of HRH1 (5% of individuals), HRH2 (1.1%) and HRH4 genes (0.9%) were also identified.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HRH2 antibodyPathways associated with anti-HRH2 antibody
 Reference Product  PubMed Publications
 JUN antibody  >4 publications with HRH2 and JUN
 HDC antibody  >2 publications with HRH2 and HDC
 ATP4A antibody  >2 publications with HRH2 and ATP4A
 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
Diseases associated with anti-HRH2 antibodyOrgans/Tissues associated with anti-HRH2 antibody
 Disease Name  Pubmed Publications
 Drug Hypersensitivity Antibodies  >3 publications with HRH2 and Drug Hypersensitivity
 Inflammation Antibodies  >2 publications with HRH2 and Inflammation
 Pain Antibodies  >2 publications with HRH2 and Pain
 Seizures Antibodies  >2 publications with HRH2 and Seizures
 Neoplasms, Experimental Antibodies  >2 publications with HRH2 and Neoplasms, Experimental
 Ulcer Antibodies  >1 publications with HRH2 and Ulcer
 Peptic Ulcer Antibodies  >1 publications with HRH2 and Peptic Ulcer
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with HRH2 and Brain
 Skin Antibodies  >2 publications with HRH2 and Skin
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