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anti-h2afy antibody :: Rabbit Histone, H2A1, Macro Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS616170 anti-h2afy antibody
Unit / Price
0.2 mL  /  $690 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Histone, H2A1, Macro (h2afy), Polyclonal Antibody

 Also Known As   

Histone, H2A1, Macro

 Product Synonym Names    Anti -Histone, H2A1, Macro
 Product Gene Name   

anti-h2afy antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 21; NC_007132.5 (44398214..44410211). Location: chromosome: 21
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Avian, Mammal, Rat
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 Specificity    Recognizes rat Histone macro H2A1.2 at 43kD and to a lesser extent macroH2A1.1. Does not crossreact with macro H2A2. Species Crossreactivity: mammals and birds.
 Purity/Purification    Serum
Serum
 Form/Format    Supplied as liquid with 0.05% sodium azide, 30% glycerol.
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 Immunogen    GST fusion-protein corresponding to the non-histone region of rat Histone macroH2A1.2 (residues 160-370).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-h2afy antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-h2afy antibody

   Autoantibodies to histone antigens have been described in patients with idiopathic and drug-induced SLE, rheumatoid arthritis, and other conditions. The presence of autoantibodies to histones are frequently found in several rheumatic disorders In one study, the predominant responses to histones in SLE sera were to H1, H2b, and H3. Marked elevations of binding occurred to H1 and H2b in 33% of patients, while 25% showed higher binding to H3 (2). The same study showed the highest anti-histone reactivity to be in patients with rheumatoid arthritis with vasculitis, while the highest reactivity in SLE sera was in those patients with a history of photosensitivity (3).
 Product Categories/Family for anti-h2afy antibody    Antibodies; Abs to Histones
 Applications Tested/Suitable for anti-h2afy antibody   

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-h2afy antibody    Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: Western Blot: A 1:500-1:2000. Detects Histone macro H2A1.2 in acid extracts of HeLa cells and mouse kidney nuclear extracts. Acid-extracted proteins from HeLa cells were resolved by electrophoresis, transferred to nitrocellulose and probed with H5110-08L (1:500). Proteins were visualized using a goat anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system.
Immunohistochemistry: A 1:50-1:200 stains hepatocyte nuclei from female mouse liver.
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NCBI/Uniprot data below describe general gene information for h2afy. It may not necessarily be applicable to this product.
 NCBI GI #    94536607
 NCBI GeneID    678613
 NCBI Accession #    NP_001035451.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001040361.1 [Other Products]
 Molecular Weight    Lysine Rich (H1, f1): ~ 21,500
Slightly Lysine Rich (H2a, f2a2): 14,004
Slightly Lysine Rich (H2b, f2b): 13,774
Arginine Rich (H3, f3): 15,324
Arginine Rich (H4, f2a1): 11,282
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 NCBI Official Full Name    H2A histone family, member Y
 NCBI Official Synonym Full Names    H2A histone family, member Y
 NCBI Official Symbol    h2afy [Similar Products]
 NCBI Official Synonym Symbols   
wu:fa93c12; zgc:136891
[Similar Products]
 NCBI Protein Information    H2A histone family, member Y; H2A1; fa93c12
 Protein Family    Core histone macro
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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