NP_006035.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
histone deacetylase 6
NCBI Official Synonym Full Names
histone deacetylase 6
NCBI Protein Information
histone deacetylase 6
UniProt Protein Name
Histone deacetylase 6
UniProt Synonym Gene Names
UniProt Entry Name
HDAC6_HUMAN
NCBI Summary for HDAC6
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]
UniProt Comments for HDAC6
HDAC6: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Interacts with CBFA2T3, HDAC11 and SIRT2. Interacts with F-actin. Interacts with BBIP10. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts with CYLD. Interacts with ZMYND15. Belongs to the histone deacetylase family. HD type 2 subfamily.
Protein type: EC 3.5.1.98; Ubiquitin conjugating system; Nuclear receptor co-regulator; Deacetylase
Chromosomal Location of Human Ortholog: Xp11.23
Cellular Component: axon; caveola; cytoplasm; cytoplasmic microtubule; cytosol; dendrite; dynein complex; histone deacetylase complex; inclusion body; leading edge; microtubule; microtubule associated complex; nucleus; perikaryon; perinuclear region of cytoplasm
Molecular Function: actin binding; alpha-tubulin binding; beta-catenin binding; beta-tubulin binding; enzyme binding; histone deacetylase activity; histone deacetylase binding; Hsp90 protein binding; microtubule binding; misfolded protein binding; NAD-dependent histone deacetylase activity (H3-K14 specific); polyubiquitin binding; protein binding; tau protein binding; tubulin deacetylase activity; ubiquitin protein ligase binding; zinc ion binding
Biological Process: histone deacetylation; intracellular protein transport; lysosome localization; macroautophagy; misfolded or incompletely synthesized protein catabolic process; mitochondrion localization; negative regulation of microtubule depolymerization; negative regulation of oxidoreductase activity; negative regulation of protein complex disassembly; negative regulation of proteolysis; negative regulation of transcription, DNA-dependent; organelle organization and biogenesis; positive regulation of signal transduction; protein amino acid deacetylation; protein complex disassembly; protein polyubiquitination; regulation of fat cell differentiation; regulation of gene expression, epigenetic; regulation of protein stability; regulation of receptor activity; response to misfolded protein; response to organic substance; response to toxin; transcription, DNA-dependent; ubiquitin-dependent protein catabolic process via the multivesicular body pathway
Disease: Chondrodysplasia With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia
Research Articles on HDAC6
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Products associated with anti-HDAC6 antibody
Pathways associated with anti-HDAC6 antibody
Diseases associated with anti-HDAC6 antibody
Organs/Tissues associated with anti-HDAC6 antibody
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