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anti-HOMER1 antibody :: Rabbit anti-Human Homer protein homolog 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7006208
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Homer protein homolog 1 (HOMER1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Homer protein homolog 1 polyclonal Antibody

 Product Synonym Names    Homer protein homolog 1 protein; HOMER1; SYN47
 Product Gene Name   

anti-HOMER1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604798
 3D Structure    ModBase 3D Structure for Q86YM7
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Homer protein homolog 1 protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-8923 / sc-20807 / sc-15321
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-HOMER1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HOMER1 antibody

   Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function.
 Product Categories/Family for anti-HOMER1 antibody    Neuroscience
 Applications Tested/Suitable for anti-HOMER1 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-HOMER1 antibody    Recommended dilution: IHC: 1:20-1:200
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 Immunohistochemistry (IHC) of anti-HOMER1 antibody    Immunohistochemistry of paraffin-embedded LO2 cells using MBS7006208 at dilution of 1:50
anti-HOMER1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for HOMER1. It may not necessarily be applicable to this product.
 NCBI GI #    459215038
 NCBI GeneID    9456
 NCBI Accession #    NP_001264006.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001277077.1 [Other Products]
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 UniProt Primary Accession #    Q86YM7 [Other Products]
 UniProt Secondary Accession #    O96003; Q86YM5; B2R688 [Other Products]
 UniProt Related Accession #    Q86YM7 [Other Products]
 Molecular Weight    19,861 Da
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 NCBI Official Full Name    homer protein homolog 1 isoform 2
 NCBI Official Synonym Full Names    homer scaffolding protein 1
 NCBI Official Symbol    HOMER1 [Similar Products]
 NCBI Official Synonym Symbols   
HOMER; SYN47; Ves-1; HOMER1A; HOMER1B; HOMER1C
[Similar Products]
 NCBI Protein Information    homer protein homolog 1
 UniProt Protein Name    Homer protein homolog 1
 Protein Family    Homer protein
 UniProt Gene Name    HOMER1 [Similar Products]
 UniProt Synonym Gene Names    SYN47; Homer-1 [Similar Products]
 UniProt Entry Name    HOME1_HUMAN
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 NCBI Summary for HOMER1    This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HOMER1    HOMER1: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Interacts with IFT57. Interacts with OPHN1. Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization. Belongs to the Homer family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5q14.2

Cellular Component: apical part of cell; axon; cell junction; costamere; postsynaptic membrane; Z disc

Molecular Function: metabotropic glutatmate receptor binding; protein binding

Biological Process: behavioral response to cocaine; chemical homeostasis within a tissue; metabotropic glutamate receptor, phospholipase C activating pathway; positive regulation of calcium ion transport; positive regulation of signal transduction; response to calcium ion; skeletal muscle contraction; skeletal muscle fiber development; synaptic transmission
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 Research Articles on HOMER1    1. The mRNA levels of Homer1, IL-1beta, and TNF-alpha in coronary artery disease patients were significantly higher than those in the control group, but not Homer2 and Homer3.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HOMER1 antibodyPathways associated with anti-HOMER1 antibody
 Reference Product  PubMed Publications
 GRM5 antibody  >10 publications with HOMER1 and GRM5
 RYR1 antibody  >4 publications with HOMER1 and RYR1
 SHANK1 antibody  >2 publications with HOMER1 and SHANK1
 GRIA1 antibody  >1 publications with HOMER1 and GRIA1
 GRM1 antibody  >1 publications with HOMER1 and GRM1
 Products by Pathway  Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
Diseases associated with anti-HOMER1 antibodyOrgans/Tissues associated with anti-HOMER1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >21 publications with HOMER1 and Nervous System Diseases
 Brain Diseases Antibodies  >9 publications with HOMER1 and Brain Diseases
 Pain Antibodies  >8 publications with HOMER1 and Pain
 Disease Models, Animal Antibodies  >7 publications with HOMER1 and Disease Models, Animal
 Learning Disorders Antibodies  >6 publications with HOMER1 and Learning Disorders
 Cocaine-Related Disorders Antibodies  >5 publications with HOMER1 and Cocaine-Related Disorders
 Movement Disorders Antibodies  >4 publications with HOMER1 and Movement Disorders
 Memory Disorders Antibodies  >4 publications with HOMER1 and Memory Disorders
 Depressive Disorder Antibodies  >4 publications with HOMER1 and Depressive Disorder
 Inflammation Antibodies  >3 publications with HOMER1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >65 publications with HOMER1 and Brain
 Nerve Antibodies  >18 publications with HOMER1 and Nerve
 Muscle Antibodies  >10 publications with HOMER1 and Muscle
 Blood Antibodies  >3 publications with HOMER1 and Blood
 Heart Antibodies  >2 publications with HOMER1 and Heart
 Eye Antibodies  >2 publications with HOMER1 and Eye
 Kidney Antibodies  >2 publications with HOMER1 and Kidney
 Salivary Gland Antibodies  >1 publications with HOMER1 and Salivary Gland
 Adrenal Gland Antibodies  >1 publications with HOMER1 and Adrenal Gland
 Liver Antibodies  >1 publications with HOMER1 and Liver
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