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anti-HSP90AA1 antibody :: Rabbit Hsp90 alpha Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175505
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Hsp90 alpha (HSP90AA1), Polyclonal Antibody

 Also Known As   

Anti-Hsp90 alpha antibody

 Product Synonym Names    Heat shock protein HSP 90-alpha; heat shock protein 90kDa alpha(cytosolic), class A member 1; Heat shock 86 kDa antibody; Heat shock 90kDa protein 1 alpha antibody; Heat shock protein 90kDa alpha(cytosolic) class A member 1 antibody; heat shock protein 90kDa alpha(cytosolic), class A member 2 antibody; Heat shock protein HSP 90-alpha antibody; HSP 86 antibody; HSP86 antibody; Hsp89 antibody; HSP89A antibody; HSP90A antibody; HSP90AA1 antibody; HSP90ALPHA antibody; HSP90N antibody; HSPC1 antibody; HSPCA antibody; HSPCAL1 antibody; HSPCAL3 antibody; HSPCAL4 antibody; HSPN antibody; LAP2 antibody; Renal carcinoma antigen NY REN 38 antibody; Renal carcinoma antigen NY-REN-38 antibody
 Product Gene Name   

anti-HSP90AA1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    140571
 3D Structure    ModBase 3D Structure for P07900
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the C-terminus of human Hsp90 alpha (676-693aa/ (2) FSLEDPQTHANRIYRMIK), identical to the related mouse and rat sequences.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-HSP90AA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-HSP90AA1 antibody

   Description: Rabbit IgG polyclonal antibody for Heat shock protein HSP 90-alpha(HSP90AA1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Background: Hsp90(heat shock protein 90) is a molecular chaperone and is one of the most abundant proteins expressed in cells. It is a member of the heat shock protein family which is upregulated in response to stress. Hsp90 is found in bacteria and all branches of eukarya, but it is apparently absent in archaea. Cytoplasmic Hsp90 is essential for viability under all conditions in eukaryotes, the bacterial homologue HtpG is dispensable under non-heat stress conditions. The function of Hsp90 includes assisting in protein folding, cell signaling, and tumor repression. This protein was first isolated by extracting proteins from stressed cells. These cells were stressed by heating, dehydrating or by other means, all of which caused the cell's proteins to begin to denature. Researchers later realized that Hsp90 has other essential functions in unstressed cells.
 Applications Tested/Suitable for anti-HSP90AA1 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

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 Testing Data of anti-HSP90AA1 antibody    anti-HSP90AA1 antibody Testing Data image
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 Testing Data #2 of anti-HSP90AA1 antibody    anti-HSP90AA1 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for HSP90AA1. It may not necessarily be applicable to this product.
 NCBI GI #    92090606
 NCBI GeneID    3320
 NCBI Accession #    P07900.5 [Other Products]
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 UniProt Primary Accession #    P07900 [Other Products]
 UniProt Secondary Accession #    Q2PP14; Q5CAQ6; Q5CAQ7; Q9BVQ5; A8K500; B3KPJ9 [Other Products]
 UniProt Related Accession #    P07900 [Other Products]
 Molecular Weight    98,161 Da
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 NCBI Official Full Name    Heat shock protein HSP 90-alpha
 NCBI Official Synonym Full Names    heat shock protein 90kDa alpha (cytosolic), class A member 1
 NCBI Official Symbol    HSP90AA1 [Similar Products]
 NCBI Official Synonym Symbols   
EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; LAP-2; HSP89A; HSP90A; HSP90N; HSPCAL1; HSPCAL4
[Similar Products]
 NCBI Protein Information    heat shock protein HSP 90-alpha; HSP 86; heat shock 86 kDa; LPS-associated protein 2; heat shock 90kD protein 1, alpha; heat shock 90kDa protein 1, alpha; renal carcinoma antigen NY-REN-38; heat shock 90kD protein, alpha-like 4; epididymis luminal secretory protein 52; heat shock 90kD protein 1, alpha-like 4; lipopolysaccharide-associated protein 2
 UniProt Protein Name    Heat shock protein HSP 90-alpha
 UniProt Synonym Protein Names   
Heat shock 86 kDa; HSP 86; HSP86; Lipopolysaccharide-associated protein 2; LAP-2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38
 Protein Family    Heat shock protein
 UniProt Gene Name    HSP90AA1 [Similar Products]
 UniProt Synonym Gene Names    HSP90A; HSPC1; HSPCA; HSP 86; HSP86; LAP-2; LPS-associated protein 2 [Similar Products]
 UniProt Entry Name    HS90A_HUMAN
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 NCBI Summary for HSP90AA1    The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
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 UniProt Comments for HSP90AA1    HSP90A: a molecular chaperone of the heat shock protein 90 family. Has ATPase activity. Known to interact with a wide variety of proteins including steroid hormone receptors, neuropeptide Y, FKBP51/54, and FKBP52. G protein-coupled receptor kinases are stabilized by interacting with HSP 90. Hsp70 and Hsp90 promote tau solubility and tau binding to microtubules, reducing insoluble tau phosphorylation of tau.

Protein type: Heat shock protein; Chaperone

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: nucleoplasm; membrane; mitochondrion; cytoplasm; plasma membrane; melanosome; extracellular region; cytosol; nucleus

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; TPR domain binding; nitric-oxide synthase regulator activity; ATPase activity; unfolded protein binding; nucleotide binding; ATP binding

Biological Process: receptor-mediated endocytosis; axon guidance; positive regulation of nitric oxide biosynthetic process; organelle organization and biogenesis; signal transduction; nitric oxide metabolic process; protein import into mitochondrial outer membrane; response to unfolded protein; mitochondrial transport; innate immune response; protein refolding; mitotic cell cycle; regulation of nitric-oxide synthase activity; vascular endothelial growth factor receptor signaling pathway; G2/M transition of mitotic cell cycle; chaperone-mediated protein complex assembly
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 Research Articles on HSP90AA1    1. this study demonstrated that although ACT1-v2-D10N is nonfunctional, ACT1-v1-D19N retains the ability to interact with Hsp90 and is fully responsive to IL-17A stimulation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HSP90AA1 antibodyPathways associated with anti-HSP90AA1 antibody
 Reference Product  PubMed Publications
 AKT1 antibody  >3 publications with HSP90AA1 and AKT1
 HIF1A antibody  >3 publications with HSP90AA1 and HIF1A
 PTGES3 antibody  >3 publications with HSP90AA1 and PTGES3
 STIP1 antibody  >2 publications with HSP90AA1 and STIP1
 NR3C1 antibody  >1 publications with HSP90AA1 and NR3C1
 CDC37 antibody  >1 publications with HSP90AA1 and CDC37
 Products by Pathway  Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Attenuation Phase Pathway antibodies  Attenuation Phase Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cellular Response To Heat Stress Pathway antibodies  Cellular Response To Heat Stress Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
Diseases associated with anti-HSP90AA1 antibodyOrgans/Tissues associated with anti-HSP90AA1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >7 publications with HSP90AA1 and Nervous System Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with HSP90AA1 and Carcinoma, Hepatocellular
 Cardiovascular Diseases Antibodies  >3 publications with HSP90AA1 and Cardiovascular Diseases
 Liver Diseases Antibodies  >3 publications with HSP90AA1 and Liver Diseases
 Lung Neoplasms Antibodies  >3 publications with HSP90AA1 and Lung Neoplasms
 Breast Neoplasms Antibodies  >3 publications with HSP90AA1 and Breast Neoplasms
 Infertility, Male Antibodies  >2 publications with HSP90AA1 and Infertility, Male
 Liver Neoplasms Antibodies  >2 publications with HSP90AA1 and Liver Neoplasms
 Neoplasm Metastasis Antibodies  >2 publications with HSP90AA1 and Neoplasm Metastasis
 Kidney Diseases Antibodies  >1 publications with HSP90AA1 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with HSP90AA1 and Blood
 Brain Antibodies  >7 publications with HSP90AA1 and Brain
 Lung Antibodies  >6 publications with HSP90AA1 and Lung
 Testis Antibodies  >6 publications with HSP90AA1 and Testis
 Liver Antibodies  >5 publications with HSP90AA1 and Liver
 Muscle Antibodies  >4 publications with HSP90AA1 and Muscle
 Vascular Antibodies  >3 publications with HSP90AA1 and Vascular
 Stomach Antibodies  >3 publications with HSP90AA1 and Stomach
 Embryonic Tissue Antibodies  >2 publications with HSP90AA1 and Embryonic Tissue
 Kidney Antibodies  >2 publications with HSP90AA1 and Kidney
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