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anti-Hspa5 antibody :: Rabbit anti-Mouse, Human Hspa5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7045622
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Hspa5, Polyclonal Antibody

★Popular Item★
 Also Known As   

Hspa5 Antibody

 Product Synonym Names    78 kDa glucose-regulated protein; GRP-78; Heat shock 70 kDa protein 5; Immunoglobulin heavy chain-binding protein; BiP; Hspa5; Grp78
 Product Gene Name   

anti-Hspa5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P20029
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse, Human
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Species    Mouse
 Immunogen    Recombinant mouse 78 kDa glucose-regulated protein (20-655AA)
 Conjugate    Non-conjugated
 Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-Hspa5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Hspa5 antibody

   Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate (By similarity).
 Applications Tested/Suitable for anti-Hspa5 antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

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 Western Blot (WB) of anti-Hspa5 antibody    Western Blot
Positive WB detected in: Rat liver tissue,Rat brain tissue,Mouse brain tissue
All lanes: Hspa5 antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 73 KDa
Observed band size: 73 KDa

anti-Hspa5 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-Hspa5 antibody    Immunofluorescent analysis of HepG-2 cells using MBS7045622 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-Hspa5 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for Hspa5. It may not necessarily be applicable to this product.
 NCBI GI #    254540168
 NCBI GeneID    14828
 NCBI Accession #    NP_001156906.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001163434.1 [Other Products]
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 UniProt Primary Accession #    P20029 [Other Products]
 UniProt Secondary Accession #    O35642; Q3UFF2; Q61630 [Other Products]
 UniProt Related Accession #    P20029 [Other Products]
 Molecular Weight    72,422 Da
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 NCBI Official Full Name    78 kDa glucose-regulated protein
 NCBI Official Synonym Full Names    heat shock protein 5
 NCBI Official Symbol    Hspa5 [Similar Products]
 NCBI Official Synonym Symbols   
Bip; Sez7; mBiP; Grp78; SEZ-7; Hsce70; baffled; AL022860; AU019543; D2Wsu17e; D2Wsu141e
[Similar Products]
 NCBI Protein Information    78 kDa glucose-regulated protein
 UniProt Protein Name    78 kDa glucose-regulated protein
 UniProt Synonym Protein Names   
Heat shock 70 kDa protein 5; Immunoglobulin heavy chain-binding protein; BiP
 UniProt Gene Name    Hspa5 [Similar Products]
 UniProt Synonym Gene Names    Grp78; GRP-78; BiP [Similar Products]
 UniProt Entry Name    GRP78_MOUSE
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 UniProt Comments for Hspa5    GRP78: a member of the HSP family of molecular chaperones required for endoplasmic reticulum integrity and stress-induced autophagy. Plays a central role in regulating the unfolded protein response (UPR), and is an obligatory component of autophagy in mammalian cells. May play an important role in cellular adaptation and oncogenic survival. One of the client proteins of GRP78 is protein double-stranded RNA-activated protein-like endoplasmic reticulum kinase (PERK). Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

Protein type: Chaperone; Heat shock protein

Cellular Component: cell surface; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; ER-Golgi intermediate compartment; focal adhesion; integral to endoplasmic reticulum membrane; membrane; midbody; mitochondrion; myelin sheath; nucleus; plasma membrane; signalosome; smooth endoplasmic reticulum

Molecular Function: ATPase activity; enzyme binding; glycoprotein binding; misfolded protein binding; protein binding; protein domain specific binding; ribosome binding; ubiquitin protein ligase binding; unfolded protein binding

Biological Process: cellular response to glucose starvation; cerebellar Purkinje cell layer development; cerebellum structural organization; ER overload response; negative regulation of apoptosis; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of cell migration; positive regulation of embryonic development; positive regulation of protein ubiquitination; proteolysis involved in cellular protein catabolic process; unfolded protein response, activation of signaling protein activity
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 Research Articles on Hspa5    1. We show that chronic VPA treatment did not modify the ATXN3 inclusion load and astrogliosis in affected brain regions However, VPA chronic treatment was able to increase GRP78 protein levels at 30 weeks of age, one of its known neuroprotective effects
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Hspa5 antibodyPathways associated with anti-Hspa5 antibody
 Reference Product  PubMed Publications
 Atf6 antibody  >43 publications with Hspa5 and Atf6
 Ern1 antibody  >12 publications with Hspa5 and Ern1
 Hsp90b1 antibody  >12 publications with Hspa5 and Hsp90b1
 Ern2 antibody  >8 publications with Hspa5 and Ern2
 Hsp90aa1 antibody  >6 publications with Hspa5 and Hsp90aa1
 Hsp90ab1 antibody  >4 publications with Hspa5 and Hsp90ab1
 Products by Pathway  Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
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 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Prion Diseases Pathway antibodies  Prion Diseases Pathway Diagram
 Prion Diseases Pathway antibodies  Prion Diseases Pathway Diagram
 Protein Export Pathway antibodies  Protein Export Pathway Diagram
 Protein Export Pathway antibodies  Protein Export Pathway Diagram
Diseases associated with anti-Hspa5 antibodyOrgans/Tissues associated with anti-Hspa5 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >86 publications with Hspa5 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >85 publications with Hspa5 and Disease Models, Animal
 Nervous System Diseases Antibodies  >84 publications with Hspa5 and Nervous System Diseases
 Brain Diseases Antibodies  >72 publications with Hspa5 and Brain Diseases
 Inflammation Antibodies  >46 publications with Hspa5 and Inflammation
 Necrosis Antibodies  >31 publications with Hspa5 and Necrosis
 Heart Diseases Antibodies  >29 publications with Hspa5 and Heart Diseases
 Liver Diseases Antibodies  >28 publications with Hspa5 and Liver Diseases
 Kidney Diseases Antibodies  >18 publications with Hspa5 and Kidney Diseases
 Obesity Antibodies  >14 publications with Hspa5 and Obesity
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >107 publications with Hspa5 and Brain
 Muscle Antibodies  >68 publications with Hspa5 and Muscle
 Blood Antibodies  >65 publications with Hspa5 and Blood
 Heart Antibodies  >55 publications with Hspa5 and Heart
 Liver Antibodies  >51 publications with Hspa5 and Liver
 Kidney Antibodies  >43 publications with Hspa5 and Kidney
 Artery Antibodies  >30 publications with Hspa5 and Artery
 Pancreas Antibodies  >24 publications with Hspa5 and Pancreas
 Lung Antibodies  >21 publications with Hspa5 and Lung
 Ovary Antibodies  >12 publications with Hspa5 and Ovary
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