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anti-ELAVL2 antibody :: Rabbit HuB Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8211333
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HuB (ELAVL2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-HuB Antibody

 Product Synonym Names    ELAVL2; HUB; ELAV-like protein 2; ELAV-like neuronal protein 1; Hu-antigen B; HuB; Nervous system-specific RNA-binding protein Hel-N1; ELAVL4; HUD; PNEM; ELAV-like protein 4; Hu-antigen D; HuD; Paraneoplastic encephalomyelitis antigen HuD
 Product Gene Name   

anti-ELAVL2 antibody

[Similar Products]
 Product Synonym Gene Name    ELAVL4 [Similar Products]
 Antibody/Peptide Pairs    HuB peptide (MBS8225624) is used for blocking the activity of HuB antibody (MBS8211333)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601673
 3D Structure    ModBase 3D Structure for Q12926
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Bovine, Chicken
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 Specificity    Recognizes endogenous levels of HuB protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the center region of human HuB. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4C. Upon delivery aliquot and store at -20C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-ELAVL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ELAVL2 antibody

   Rabbit polyclonal antibody to HuB
 Applications Tested/Suitable for anti-ELAVL2 antibody   

Western Blot (WB),Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

 Application Notes for anti-ELAVL2 antibody    WB (1/500 - 1/1000)
IHC (1/100 - 1/200)
IF (1/100 - 1/500
ICC (1/100 - 1/500)
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 Western Blot (WB) of anti-ELAVL2 antibody    Western blot analysis of HuB expression in K562 (A), HeLa (B) whole cell lysates.
anti-ELAVL2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ELAVL2 antibody    Immunohistochemical analysis of HuB staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-ELAVL2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-ELAVL2 antibody    Immunofluorescent analysis of HuB staining in K562 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 degree C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
anti-ELAVL2 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for ELAVL2. It may not necessarily be applicable to this product.
 NCBI GI #    283945529
 NCBI GeneID    1993
 NCBI Accession #    NP_001164666.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001171195.1 [Other Products]
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 UniProt Primary Accession #    Q12926 [Other Products]
 UniProt Secondary Accession #    Q13235; Q59G15; Q8NEM4; Q9H1Q8; D3DRK3 [Other Products]
 UniProt Related Accession #    Q12926 [Other Products]
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 NCBI Official Full Name    ELAV-like protein 2 isoform b
 NCBI Official Synonym Full Names    ELAV like neuron-specific RNA binding protein 2
 NCBI Official Symbol    ELAVL2 [Similar Products]
 NCBI Official Synonym Symbols   
HUB; HELN1; HEL-N1
[Similar Products]
 NCBI Protein Information    ELAV-like protein 2
 UniProt Protein Name    ELAV-like protein 2
 UniProt Synonym Protein Names   
ELAV-like neuronal protein 1; Hu-antigen B; HuB; Nervous system-specific RNA-binding protein Hel-N1
 Protein Family    ELAV-like protein
 UniProt Gene Name    ELAVL2 [Similar Products]
 UniProt Synonym Gene Names    HUB; HuB [Similar Products]
 UniProt Entry Name    ELAV2_HUMAN
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 NCBI Summary for ELAVL2    The protein encoded by this gene is a neural-specific RNA-binding protein that is known to bind to several 3' UTRs, including its own and also that of FOS and ID. The encoded protein may recognize a GAAA motif in the RNA. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
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 UniProt Comments for ELAVL2    ELAVL2: Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR. Belongs to the RRM elav family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 9p21

Molecular Function: protein binding; mRNA 3'-UTR binding; nucleotide binding

Biological Process: regulation of transcription, DNA-dependent
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 Research Articles on ELAVL2    1. Tests for gene-environment interaction between these 33 genes and maternal smoking found evidence for interaction with two additional genes: GRID2 and ELAVL2 among European mothers
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-ELAVL2 antibodyOrgans/Tissues associated with anti-ELAVL2 antibody
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >7 publications with ELAVL2 and Lung Neoplasms
 Small Cell Lung Carcinoma Antibodies  >7 publications with ELAVL2 and Small Cell Lung Carcinoma
 Breast Neoplasms Antibodies  >2 publications with ELAVL2 and Breast Neoplasms
 Liver Neoplasms Antibodies  >2 publications with ELAVL2 and Liver Neoplasms
 Immune System Diseases Antibodies  >1 publications with ELAVL2 and Immune System Diseases
 Growth Disorders Antibodies  >1 publications with ELAVL2 and Growth Disorders
 Neoplasm Metastasis Antibodies  >1 publications with ELAVL2 and Neoplasm Metastasis
 Fetal Growth Retardation Antibodies  >1 publications with ELAVL2 and Fetal Growth Retardation
 Congenital Abnormalities Antibodies  >1 publications with ELAVL2 and Congenital Abnormalities
 Necrosis Antibodies  >1 publications with ELAVL2 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >16 publications with ELAVL2 and Brain
 Embryonic Tissue Antibodies  >13 publications with ELAVL2 and Embryonic Tissue
 Mammary Gland Antibodies  >1 publications with ELAVL2 and Mammary Gland
 Eye Antibodies  >1 publications with ELAVL2 and Eye
 Testis Antibodies  >1 publications with ELAVL2 and Testis
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