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anti-HIP1 antibody :: Rabbit anti-Human Huntingtin-interacting protein 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1493805
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Huntingtin-interacting protein 1 (HIP1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Huntingtin-interacting protein 1 polyclonal Antibody(HIP1)

 Product Synonym Names    HIP-1; Huntingtin-interacting protein I; HIP-I
 Product Gene Name   

anti-HIP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601767
 3D Structure    ModBase 3D Structure for O00291
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Huntingtin-interacting protein 1 protein(410-690aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-20897 / sc-20899 / sc-33601
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-HIP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HIP1 antibody

   Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.
 Applications Tested/Suitable for anti-HIP1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-HIP1 antibody    Recommended dilution: WB:1:200-1000
IHC:1:20-1:200
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 Western Blot (WB) of anti-HIP1 antibody    Western blot
All lanes: HIP1 antibody at 4ug/ml+A549 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 117,111,114 kDa
Observed band size: 116 kDa

anti-HIP1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-HIP1 antibody    Immunohistochemistry of paraffin-embedded human colorectal carcinoma using MBS1493805 at dilution 1:100
anti-HIP1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-HIP1 antibody    Immunohistochemistry of paraffin-embedded human placenta using MBS1493805 at dilution 1:100
anti-HIP1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for HIP1. It may not necessarily be applicable to this product.
 NCBI GI #    342307096
 NCBI GeneID    3092
 NCBI Accession #    NP_001230127.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001243198.2 [Other Products]
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 UniProt Primary Accession #    O00291 [Other Products]
 UniProt Secondary Accession #    O00328; Q2TB58; Q8TDL4; B4E3I7; E7ES17; V5LU97 [Other Products]
 UniProt Related Accession #    O00291 [Other Products]
 Molecular Weight    113,076 Da
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 NCBI Official Full Name    huntingtin-interacting protein 1 isoform 2
 NCBI Official Synonym Full Names    huntingtin interacting protein 1
 NCBI Official Symbol    HIP1 [Similar Products]
 NCBI Official Synonym Symbols   
SHON; HIP-I; ILWEQ; SHONbeta; SHONgamma
[Similar Products]
 NCBI Protein Information    huntingtin-interacting protein 1
 UniProt Protein Name    Huntingtin-interacting protein 1
 UniProt Synonym Protein Names   
Huntingtin-interacting protein I; HIP-I
 Protein Family    Histidine permease
 UniProt Gene Name    HIP1 [Similar Products]
 UniProt Synonym Gene Names    HIP-1; HIP-I [Similar Products]
 UniProt Entry Name    HIP1_HUMAN
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 NCBI Summary for HIP1    The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
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 UniProt Comments for HIP1    HIP1: Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors. A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB. The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes. The reciprocal PDGFRB-HIP1 transcript is not expressed. Belongs to the SLA2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cytoskeletal

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: clathrin coated vesicle membrane; clathrin-coated vesicle; cytoplasm; cytoskeleton; Golgi apparatus; intracellular membrane-bound organelle; membrane; nucleus

Molecular Function: actin binding; clathrin binding; phosphoinositide binding; protein binding; structural constituent of cytoskeleton

Biological Process: apoptosis; caspase activation; cell differentiation; clathrin cage assembly; positive regulation of receptor-mediated endocytosis; regulation of apoptosis; regulation of transcription, DNA-dependent; transcription, DNA-dependent

Disease: Prostate Cancer
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 Research Articles on HIP1    1. SHON plays an important role in EMT and contributes to breast cancer progression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-HIP1 antibodyDiseases associated with anti-HIP1 antibody
 Products by Pathway  Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Disease Name  Pubmed Publications
 Cognition Disorders Antibodies  >29 publications with HIP1 and Cognition Disorders
 Prostatic Diseases Antibodies  >6 publications with HIP1 and Prostatic Diseases
 Cardiovascular Diseases Antibodies  >6 publications with HIP1 and Cardiovascular Diseases
 Prostatic Neoplasms Antibodies  >6 publications with HIP1 and Prostatic Neoplasms
 Neurobehavioral Manifestations Antibodies  >4 publications with HIP1 and Neurobehavioral Manifestations
 Lung Neoplasms Antibodies  >4 publications with HIP1 and Lung Neoplasms
 Skin Neoplasms Antibodies  >3 publications with HIP1 and Skin Neoplasms
 Immune System Diseases Antibodies  >3 publications with HIP1 and Immune System Diseases
 Weight Loss Antibodies  >3 publications with HIP1 and Weight Loss
 Liver Neoplasms Antibodies  >2 publications with HIP1 and Liver Neoplasms
Organs/Tissues associated with anti-HIP1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >43 publications with HIP1 and Brain
 Nerve Antibodies  >31 publications with HIP1 and Nerve
 Lung Antibodies  >8 publications with HIP1 and Lung
 Prostate Antibodies  >7 publications with HIP1 and Prostate
 Skin Antibodies  >5 publications with HIP1 and Skin
 Liver Antibodies  >5 publications with HIP1 and Liver
 Bone Antibodies  >4 publications with HIP1 and Bone
 Kidney Antibodies  >4 publications with HIP1 and Kidney
 Heart Antibodies  >3 publications with HIP1 and Heart
 Bone Marrow Antibodies  >3 publications with HIP1 and Bone Marrow
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