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anti-HABP2 antibody :: Rabbit anti-Bovine Hyaluronic Acid Binding Protein Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS617337 anti-HABP2 antibody
Unit / Price
1 mL  /  $445 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Hyaluronic Acid Binding Protein (HABP2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Hyaluronic Acid Binding Protein (Hyaluronan Binding Protein, HABP)

 Product Synonym Names    Anti -Hyaluronic Acid Binding Protein (Hyaluronan Binding Protein, HABP)
 Product Gene Name   

anti-HABP2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 10; NC_000010.10 (115310590..115349361). Location: 10q25.3
 OMIM    603924
 3D Structure    ModBase 3D Structure for Q14520
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Bovine
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 Specificity    Recognizes Hyaluronic Acid Binding Protein (HABP). Species Crossreactivity: Mouse and rat.
 Purity/Purification    Serum
Neat serum
 Form/Format    Supplied as a liquid, serum, before the addition of glycerol to 40%.
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 Immunogen    Bovine Hyaluronic Acid Binding Protein (HABP)
 Similar Product    MBS651823 Hyaluronic Acid Binding Protein (HABP)
MBS617337 Hyaluronic Acid Binding Protein (HABP) Pab Rb xBo
MBS651801 Hyaluronic Acid Binding Protein (HABP) (Biotin).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-HABP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-HABP2 antibody

   Hyaluronan binding protein 1 (HABP1), also known as C1qBP/C1qR and p32, is a ubiquitous acidic glycoprotein that functions in spermatogenesis and as a receptor for proinflammatory molecules (1, 2). HABP1 is synthesized with a 71 amino acid (aa) N-terminal preproprotein and a 208 aa mature region (3). The 3kD mature mouse HABP1, which contains a MAM33-like sequence, shares 90% and 99% aa sequence identity with human and rat HABP1, respectively. HABP1 assembles into a doughnut shaped trimer, with negatively charged residues asymmetrically distributed on one face lining the channel of the complex (4). HABP1 can be cleaved by cell surface MMP-14/MT1-MMP, a protease important in angiogenesis and tumor metastasis (5). Cell surface HABP1 binds a wide range of extracellular molecules, including hyaluronan, vitronectin, complement component C1q, HMW kininogen, and bacterial and viral proteins (2, 6-9). Within the cell, HABP1 binds to molecules containing the C1q globular domain, multiple isoforms of PKC, mitochondrial Hrk, the cytoplasmic tails of adrenergic and GABA-A receptors, the mRNA splicing factor ASF/SF2, and the CBF transcription factor (10-16). Apoptosis and direct phosphorylation by Erk1/2 induces HABP1 translocation to the nucleus (17).
 Product Categories/Family for anti-HABP2 antibody    Antibodies; Abs to Carbohydrates, Glycoproteins
 Applications Tested/Suitable for anti-HABP2 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

 Application Notes for anti-HABP2 antibody    Suitable for use in ELISA, Western Blot, Immunohistochemistry and Immunocytochemistry.
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NCBI/Uniprot data below describe general gene information for HABP2. It may not necessarily be applicable to this product.
 NCBI GI #    295054188
 NCBI GeneID    3026
 NCBI Accession #    NP_001171131.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001177660.1 [Other Products]
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 UniProt Primary Accession #    Q14520 [Other Products]
 UniProt Secondary Accession #    O00663; A8K467; B7Z8U5; F5H5M6 [Other Products]
 UniProt Related Accession #    Q14520 [Other Products]
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 NCBI Official Full Name    hyaluronan-binding protein 2 isoform 2
 NCBI Official Synonym Full Names    hyaluronan binding protein 2
 NCBI Official Symbol    HABP2 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    hyaluronan-binding protein 2; factor VII activating protein; factor VII-activating protease; factor seven-activating protease; hyaluronic acid binding protein 2; plasma hyaluronan binding protein; plasma hyaluronan-binding protein; hepatocyte growth factor activator-like protein
 UniProt Protein Name    Hyaluronan-binding protein 2
 UniProt Synonym Protein Names   
Factor VII-activating protease; Factor seven-activating protease; FSAP; Hepatocyte growth factor activator-like protein; Plasma hyaluronan-binding protein
 Protein Family    Hyaluronan-binding protein
 UniProt Gene Name    HABP2 [Similar Products]
 UniProt Synonym Gene Names    HGFAL; PHBP; FSAP [Similar Products]
 UniProt Entry Name    HABP2_HUMAN
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 NCBI Summary for HABP2    The protein encoded by this gene is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. The encoded protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This protease is known to cleave urinary plasminogen activator, coagulation factor VII, and the alpha and beta chains of fibrinogen, but not prothrombin, plasminogen, or the gamma chain of fibrinogen. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
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 UniProt Comments for HABP2    HABP2: Cleaves the alpha-chain at multiple sites and the beta- chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro- urokinase) to the active two chain form. Activates coagulation factor VII. Belongs to the peptidase S1 family.

Protein type: Secreted; Motility/polarity/chemotaxis; Protease; Cell adhesion; EC 3.4.21.-; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q25.3

Cellular Component: extracellular space; extracellular region

Molecular Function: glycosaminoglycan binding; serine-type endopeptidase activity

Biological Process: proteolysis; cell adhesion

Disease: Thrombophilia Due To Thrombin Defect; Thyroid Cancer, Nonmedullary, 5
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 Research Articles on HABP2    1. The study demonstrated that a single nucleotide polymorphism (Marburg I) in the FSAP gene (HABP-2)results in a weak proteolytic activity against all substrates including FVII.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HABP2 antibodyDiseases associated with anti-HABP2 antibody
 Reference Product  PubMed Publications
 SERPINE1 antibody  >3 publications with HABP2 and SERPINE1
 KNG1 antibody  >1 publications with HABP2 and KNG1
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >15 publications with HABP2 and Inflammation
 Atherosclerosis Antibodies  >10 publications with HABP2 and Atherosclerosis
 Nervous System Diseases Antibodies  >7 publications with HABP2 and Nervous System Diseases
 Neoplasms Antibodies  >5 publications with HABP2 and Neoplasms
 Thrombophilia Antibodies  >5 publications with HABP2 and Thrombophilia
 Liver Diseases Antibodies  >4 publications with HABP2 and Liver Diseases
 Lung Neoplasms Antibodies  >3 publications with HABP2 and Lung Neoplasms
 Edema Antibodies  >2 publications with HABP2 and Edema
 Adenocarcinoma Antibodies  >2 publications with HABP2 and Adenocarcinoma
 Pain Antibodies  >2 publications with HABP2 and Pain
Organs/Tissues associated with anti-HABP2 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >48 publications with HABP2 and Blood
 Lung Antibodies  >8 publications with HABP2 and Lung
 Liver Antibodies  >8 publications with HABP2 and Liver
 Heart Antibodies  >3 publications with HABP2 and Heart
 Embryonic Tissue Antibodies  >2 publications with HABP2 and Embryonic Tissue
 Kidney Antibodies  >2 publications with HABP2 and Kidney
 Connective Tissue Antibodies  >1 publications with HABP2 and Connective Tissue
 Uterus Antibodies  >1 publications with HABP2 and Uterus
 Pancreas Antibodies  >1 publications with HABP2 and Pancreas
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