NP_001230045.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,530 Da
NCBI Official Full Name
NF-kappa-B inhibitor beta isoform 2
NCBI Official Synonym Full Names
NFKB inhibitor beta
NCBI Official Synonym Symbols
NCBI Protein Information
NF-kappa-B inhibitor beta
UniProt Protein Name
NF-kappa-B inhibitor beta
UniProt Synonym Protein Names
I-kappa-B-beta; IkB-B; IkB-beta; IkappaBbeta; Thyroid receptor-interacting protein 9; TR-interacting protein 9; TRIP-9
UniProt Synonym Gene Names
IKBB; TRIP9; NF-kappa-BIB; IkB-B; IkB-beta; IkappaBbeta; TR-interacting protein 9; TRIP-9 [Similar Products]
NCBI Summary for IKBB
The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]
UniProt Comments for IKBB
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Product References and Citations for anti-IKBB antibody
Lee J.W., Mol. Endocrinol. 9:243-254(1995). Kalnine N., Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. The MGC Project Team; Genome Res. 14:2121-2127(2004).
Research Articles on IKBB
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Products associated with anti-IKBB antibody
Pathways associated with anti-IKBB antibody
Diseases associated with anti-IKBB antibody
Organs/Tissues associated with anti-IKBB antibody
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