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anti-ICAD antibody :: Rabbit ICAD Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS221592
Testing Data #1
Unit / Price
0.1 mg  /  $320 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ICAD, Polyclonal Antibody

 Also Known As   

RABBIT ANTI MOUSE ICAD (C-TERMINAL)

 Product Gene Name   

anti-ICAD antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for O54786
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
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 Specificity    ICAD (Inhibitor of Caspase-Activated DNase) is the murine homologue of human DFF-45. ICAD is cleaved by Caspase-3, releasing CAD which eventually causes degradation of DNA in the nucleus. This item recognises a 45kD band in Western blots.
 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 0.5mg/ml (lot specific)
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 Perservative Stabilisers    0.02% Sodium Azide
 Immunogen    Synthetic peptide corresponding to amino acids 312-331 of mouse ICAD
Buffer Solution
 Antiserum Preparation    Antisera to murine ICAD were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
 Target Species    Mouse
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-ICAD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ICAD antibody

   ICAD (Inhibitor of Caspase-Activated DNase) is the murine homologue of human DFF-45. ICAD is cleaved by Caspase-3, releasing CAD which eventually causes degradation of DNA in the nucleus. MBS221591 recognises a 45kD band in Western blots.
 Applications Tested/Suitable for anti-ICAD antibody   

Western Blot (WB)

 Application Notes for anti-ICAD antibody    Western Blotting: Minimum Dilution: 1/500; Maximum Dilution: 1/1000
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 Testing Data #1 of anti-ICAD antibody    Western blot analysis of lysates from mouse lung (L), brain (B), liver (L) and kidney (K) probed with Rabbit anti Mouse ICAD) (MBS221592)
anti-ICAD antibody Testing Data #1 image
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NCBI/Uniprot data below describe general gene information for ICAD. It may not necessarily be applicable to this product.
 NCBI GI #    70608119
 NCBI GeneID    13347
 NCBI Accession #    NP_001020467.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001025296.2 [Other Products]
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 UniProt Primary Accession #    O54786 [Other Products]
 UniProt Secondary Accession #    O54787; Q8BQC7; B2KFX0 [Other Products]
 UniProt Related Accession #    O54786 [Other Products]
 Molecular Weight    29,183 Da
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 NCBI Official Full Name    DNA fragmentation factor subunit alpha isoform a
 NCBI Official Synonym Full Names    DNA fragmentation factor, alpha subunit
 NCBI Official Symbol    Dffa [Similar Products]
 NCBI Official Synonym Symbols   
ICAD; DFF35; Dff45; ICAD-L; ICAD-S; A330085O09Rik
[Similar Products]
 NCBI Protein Information    DNA fragmentation factor subunit alpha; DNA fragmentation factor 45 kDa subunit; inhibitor of CAD
 UniProt Protein Name    DNA fragmentation factor subunit alpha
 UniProt Synonym Protein Names   
DNA fragmentation factor 45 kDa subunit; DFF-45; Inhibitor of CAD; ICAD
 Protein Family    Poly-beta-1,6-N-acetyl-D-glucosamine synthesis protein
 UniProt Gene Name    Dffa [Similar Products]
 UniProt Synonym Gene Names    Icad; DFF-45; ICAD [Similar Products]
 UniProt Entry Name    DFFA_MOUSE
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 UniProt Comments for ICAD    DFFA: Inhibitor of the caspase-activated DNase (DFF40). Heterodimer of DFFA and DFFB. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase

Cellular Component: nucleoplasm; cytoplasm; nuclear chromatin; intracellular; cytosol; nucleus

Molecular Function: protein binding

Biological Process: apoptosis; positive regulation of apoptosis
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 Research Articles on ICAD    1. apoptotic DNA fragmentation factor is required for the maintenance of genetic stability and may play a role in tumor suppression
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ICAD antibodyDiseases associated with anti-ICAD antibody
 Products by Pathway  Pathway Diagram
 Activation Of DNA Fragmentation Factor Pathway antibodies  Activation Of DNA Fragmentation Factor Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Induced DNA Fragmentation Pathway antibodies  Apoptosis Induced DNA Fragmentation Pathway Diagram
 Apoptosis Signaling Pathway antibodies  Apoptosis Signaling Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 FAS Pathway And Stress Induction Of HSP Regulation antibodies  FAS Pathway And Stress Induction Of HSP Regulation Diagram
 PluriNetWork Pathway antibodies  PluriNetWork Pathway Diagram
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >8 publications with ICAD and Necrosis
 Carcinoma Antibodies  >5 publications with ICAD and Carcinoma
 Fatty Liver Antibodies  >5 publications with ICAD and Fatty Liver
 Liver Diseases Antibodies  >4 publications with ICAD and Liver Diseases
 Cardiovascular Diseases Antibodies  >4 publications with ICAD and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >3 publications with ICAD and Disease Models, Animal
 Inflammation Antibodies  >3 publications with ICAD and Inflammation
 Uterine Cervical Neoplasms Antibodies  >2 publications with ICAD and Uterine Cervical Neoplasms
 Nervous System Diseases Antibodies  >2 publications with ICAD and Nervous System Diseases
 Neoplasm Invasiveness Antibodies  >1 publications with ICAD and Neoplasm Invasiveness
Organs/Tissues associated with anti-ICAD antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >11 publications with ICAD and Liver
 Connective Tissue Antibodies  >9 publications with ICAD and Connective Tissue
 Muscle Antibodies  >4 publications with ICAD and Muscle
 Kidney Antibodies  >3 publications with ICAD and Kidney
 Heart Antibodies  >3 publications with ICAD and Heart
 Bone Antibodies  >3 publications with ICAD and Bone
 Bone Marrow Antibodies  >2 publications with ICAD and Bone Marrow
 Eye Antibodies  >2 publications with ICAD and Eye
 Skin Antibodies  >1 publications with ICAD and Skin
 Lung Antibodies  >1 publications with ICAD and Lung
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