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anti-IDH1 antibody :: Rabbit IDH1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151017
Western Blot (WB)
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IDH1, Polyclonal Antibody

★Popular Item★
 Also Known As   

IDH1 Antibody

 Product Synonym Names    IDH1; IDH; IDP; IDCD; IDPC; PICD; HEL-216; HEL-S-26; Cytosolic NADP-isocitrate dehydrogenase; IDH; isocitrate dehydrogenase 1 (NADP+), soluble
 Product Gene Name   

anti-IDH1 antibody

[Similar Products]
 Antibody/Peptide Pairs    IDH1 peptide (MBS151805) is used for blocking the activity of IDH1 antibody (MBS151017)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 147700
 3D Structure    ModBase 3D Structure for O75874
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    IDH1 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    IDH1 antibody was raised against a 13 amino acid synthetic peptide near the carboxy terminus of human IDH1.
 Buffer    IDH1 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    IDH1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-IDH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IDH1 antibody

   IDH1 Antibody: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Two NADP(+)-dependent isocitrate dehydrogenases have been found as homodimer: IDH1 is predominantly cytosolic and peroxisomal and IDH2 is mitochondrial. The presence of IDH1 in peroxisomes suggests it may play a role in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic IDH1 serves a significant role in cytoplasmic NADPH production. Defects in IDH1 are involved in the development of glioma.
 Applications Tested/Suitable for anti-IDH1 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-IDH1 antibody    IDH1 antibody can be used for detection of IDH1 by Western blot at 1 - 2 mug/mL.
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 Western Blot (WB) of anti-IDH1 antibody    Western blot analysis of IDH1 in HepG2 cell lysate with IDH1 antibody at (A) 1 and (B) 2 μg/mL.
anti-IDH1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for IDH1. It may not necessarily be applicable to this product.
 NCBI GI #    28178825
 NCBI GeneID    3417
 NCBI Accession #    NP_005887 [Other Products]
 NCBI GenBank Nucleotide #    NM_005896.3 [Other Products]
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 UniProt Primary Accession #    O75874 [Other Products]
 UniProt Secondary Accession #    Q567U4; Q6FHQ6; Q7Z3V0; Q93090; Q9NTJ9; Q9UKW8 [Other Products]
 UniProt Related Accession #    O75874 [Other Products]
 Molecular Weight    46,659 Da
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 NCBI Official Full Name    isocitrate dehydrogenase
 NCBI Official Synonym Full Names    isocitrate dehydrogenase 1 (NADP+), soluble
 NCBI Official Symbol    IDH1 [Similar Products]
 NCBI Official Synonym Symbols   
IDH; IDP; IDCD; IDPC; PICD; HEL-216; HEL-S-26
[Similar Products]
 NCBI Protein Information    isocitrate dehydrogenase [NADP] cytoplasmic; isocitrate dehydrogenase [NADP] cytoplasmic; NADP(+)-specific ICDH; oxalosuccinate decarboxylase; epididymis luminal protein 216; epididymis secretory protein Li 26; NADP-dependent isocitrate dehydrogenase, cytosolic; NADP-dependent isocitrate dehydrogenase, peroxisomal
 UniProt Protein Name    Isocitrate dehydrogenase [NADP] cytoplasmic
 UniProt Synonym Protein Names   
Cytosolic NADP-isocitrate dehydrogenase; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase
 Protein Family    Isocitrate dehydrogenase
 UniProt Gene Name    IDH1 [Similar Products]
 UniProt Synonym Gene Names    PICD; IDH [Similar Products]
 UniProt Entry Name    IDHC_HUMAN
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 NCBI Summary for IDH1    Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
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 UniProt Comments for IDH1    IDH1: an oxidoreductase that catalyzes the third step of the TCA cycle: the oxidative decarboxylation of isocitrate, consuming NADP(+), and producing alpha-ketoglutarate (alpha-KG) and CO2. Alpha-KG is an activator the dioxygenases that hydroxylate the transcription factor HIF and lead to its degradation by VHL. Since HIF turns on oncogenic pathways, IDH1 has apparent tumor suppressor activity. Homo-dimerization is required for activity. Each subunit binds 1 magnesium or manganese ion. IDH1 is located in the cytosol and peroxisomes. Somatic mutations affecting arginine 132 (R132) are found in 80% of grade II?III gliomas and secondary glioblastomas in humans, and cause disease in a tissue-specific fashion. Only a single copy of the gene has been found to be mutated in tumours. Mutations of R132 to H, C, S, G, V, or L have been reported to be neomorphic, abolishing the conversion of isocitrate to alpha-KG. Instead, alpha-KG is converted to R(-)-2-hydroxyglutarate (2HG). Elevated levels of 2HG correlate with an elevated risk of malignant brain tumors. Neomorphic mutations in IDH1 and IDH2 convert alpha-KG to 2-hydroxyglutarate (2-HG) occur in a high percentage of patients with cytogenetically normal acute myeloid leukemia (AML).

Protein type: EC 1.1.1.42; Carbohydrate Metabolism - citrate (TCA) cycle; Other Amino Acids Metabolism - glutathione; Oxidoreductase

Chromosomal Location of Human Ortholog: 2q33.3

Cellular Component: peroxisomal matrix; mitochondrion; cytoplasm; peroxisome; cytosol

Molecular Function: protein homodimerization activity; magnesium ion binding; isocitrate dehydrogenase (NADP+) activity; NADP binding; NAD binding; receptor binding

Biological Process: glyoxylate cycle; NADPH regeneration; isocitrate metabolic process; glutathione metabolic process; response to steroid hormone stimulus; tricarboxylic acid cycle; response to oxidative stress; cellular lipid metabolic process; female gonad development; 2-oxoglutarate metabolic process

Disease: Glioma Susceptibility 1
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 Research Articles on IDH1    1. These data suggest that IDH1 (R132H) mutation increases radiosensitivity in mild hypoxic conditions.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IDH1 antibodyPathways associated with anti-IDH1 antibody
 Reference Product  PubMed Publications
 HIF1A antibody  >11 publications with IDH1 and HIF1A
 ACO1 antibody  >4 publications with IDH1 and ACO1
 GOT1 antibody  >2 publications with IDH1 and GOT1
 GLUD1 antibody  >1 publications with IDH1 and GLUD1
 GOT2 antibody  >1 publications with IDH1 and GOT2
 Products by Pathway  Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 Abnormal Conversion Of 2-oxoglutarate To 2-hydroxyglutarate Pathway antibodies  Abnormal Conversion Of 2-oxoglutarate To 2-hydroxyglutarate Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
Diseases associated with anti-IDH1 antibodyOrgans/Tissues associated with anti-IDH1 antibody
 Disease Name  Pubmed Publications
 Glioma Antibodies  >603 publications with IDH1 and Glioma
 Nervous System Diseases Antibodies  >472 publications with IDH1 and Nervous System Diseases
 Oligodendroglioma Antibodies  >127 publications with IDH1 and Oligodendroglioma
 Necrosis Antibodies  >26 publications with IDH1 and Necrosis
 Neoplasms, Experimental Antibodies  >19 publications with IDH1 and Neoplasms, Experimental
 Intrahepatic cholangiocarcinoma Antibodies  >15 publications with IDH1 and Intrahepatic cholangiocarcinoma
 Disease Models, Animal Antibodies  >15 publications with IDH1 and Disease Models, Animal
 Anemia Antibodies  >12 publications with IDH1 and Anemia
 Lung Neoplasms Antibodies  >12 publications with IDH1 and Lung Neoplasms
 Liver Neoplasms Antibodies  >12 publications with IDH1 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >537 publications with IDH1 and Brain
 Blood Antibodies  >108 publications with IDH1 and Blood
 Bone Antibodies  >65 publications with IDH1 and Bone
 Bone Marrow Antibodies  >39 publications with IDH1 and Bone Marrow
 Nerve Antibodies  >27 publications with IDH1 and Nerve
 Vascular Antibodies  >25 publications with IDH1 and Vascular
 Liver Antibodies  >25 publications with IDH1 and Liver
 Lung Antibodies  >14 publications with IDH1 and Lung
 Skin Antibodies  >9 publications with IDH1 and Skin
 Prostate Antibodies  >9 publications with IDH1 and Prostate
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