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anti-IDS antibody :: Goat IDS Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS243534
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IDS, Polyclonal Antibody

 Also Known As   

Goat Polyclonal to Human IDS

 Product Synonym Names    Anti-IDS Antibody (Internal) IHC-plus; IDS; Idursulfase; SIDS; Iduronate 2-sulfatase; MPS2; Human IDS
 Product Gene Name   

anti-IDS antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 309900
 3D Structure    ModBase 3D Structure for P22304
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Gibbon, Gorilla, Human, Monkey
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 Specificity    Human IDS. This antibody is expected to recognize isoform a (NP_000193.1).
 Purity/Purification    Immunoaffinity Purified
 Form/Format    Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide C-KHFRFRDLEEDP from an internal region of human IDS (NP_000193.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Marmoset, Panda (83%).
 Immunogen Type    Synthetic peptide
 Immunogen    IDS antibody was raised against synthetic peptide C-KHFRFRDLEEDP from an internal region of human IDS (NP_000193.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Marmoset, Panda (83%).
 Antigen Modification    Internal
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 Preparation and Storage    Store at -20 degree C. Minimize freezing and thawing.
 Other Notes    Small volumes of anti-IDS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-IDS antibody

   Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked Mucopolysaccharidosis Type II, also known as Hunter Syndrome. Iduronate-2-sulfatase has a strong sequence homology with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. A splice variant of this gene has been described.
 Applications Tested/Suitable for anti-IDS antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-IDS antibody    ELISA (1:16000), IHC-P (3.75 ug/ml), WB (0.1 - 0.3 ug/ml)
Usage: Peptide ELISA: antibody detection limit dilution 1:16000. Western blot: Approx. 60kDa band observed in Human Liver lysates (calculated MW of 61.9kDa according to NP_000193.1). Recommended concentration: 0.1-0.3 ug/ml.
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 Immunohistochemistry (IHC) of anti-IDS antibody    Anti-IDS antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 3.75 ug/ml.
anti-IDS antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-IDS antibody    IDS antibody (0.1 ug/ml) staining of Human Liver lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-IDS antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for IDS. It may not necessarily be applicable to this product.
 NCBI GI #    4557659
 NCBI GeneID    3423
 NCBI Accession #    NP_000193.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000202.6 [Other Products]
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 UniProt Primary Accession #    P22304 [Other Products]
 UniProt Secondary Accession #    Q14604; Q9BRM3; D3DWT4 [Other Products]
 UniProt Related Accession #    P22304 [Other Products]
 Molecular Weight    34,893 Da
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 NCBI Official Full Name    iduronate 2-sulfatase isoform a preproprotein
 NCBI Official Synonym Full Names    iduronate 2-sulfatase
 NCBI Official Symbol    IDS [Similar Products]
 NCBI Official Synonym Symbols   
MPS2; SIDS
[Similar Products]
 NCBI Protein Information    iduronate 2-sulfatase; idursulfase; iduronate 2-sulfatase 14 kDa chain; iduronate 2-sulfatase 42 kDa chain; alpha-L-iduronate sulfate sulfatase
 UniProt Protein Name    Iduronate 2-sulfatase
 UniProt Synonym Protein Names   
Alpha-L-iduronate sulfate sulfatase; Idursulfase
 Protein Family    Iduronate 2-sulfatase
 UniProt Gene Name    IDS [Similar Products]
 UniProt Synonym Gene Names    SIDS; Idursulfase [Similar Products]
 UniProt Entry Name    IDS_HUMAN
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 NCBI Summary for IDS    The protein encoded by this gene belongs to the sulfatase family, is localized to the lysosome, and is involved in lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X-linked lysosomal storage disease, mucopolysaccharidosis type II, also known as Hunter syndrome. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Aug 2013]
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 UniProt Comments for IDS    IDS: Required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Defects in IDS are the cause of mucopolysaccharidosis type 2 (MPS2); also known as Hunter syndrome. MPS2 is an X-linked lysosomal storage disease characterized by intracellular accumulation of heparan sulfate and dermatan sulfate and their excretion in urine. Most children with MPS2 have a severe form with early somatic abnormalities including skeletal deformities, hepatosplenomegaly, and progressive cardiopulmonary deterioration. A prominent feature is neurological damage that presents as developmental delay and hyperactivity but progresses to mental retardation and dementia. They die before 15 years of age, usually as a result of obstructive airway disease or cardiac failure. In contrast, those with a mild form of MPS2 may survive into adulthood, with attenuated somatic complications and often without mental retardation. Belongs to the sulfatase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Glycan Metabolism - glycosaminoglycan degradation; EC 3.1.6.13; Hydrolase

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: lysosomal lumen

Molecular Function: iduronate-2-sulfatase activity; metal ion binding

Biological Process: chondroitin sulfate metabolic process; glycosaminoglycan catabolic process; glycosaminoglycan metabolic process; chondroitin sulfate catabolic process; carbohydrate metabolic process; pathogenesis

Disease: Mucopolysaccharidosis, Type Ii
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 Research Articles on IDS    1. This study evaluated a novel mutation in the IDS gene among 8 male Hunter syndrome patients; there was a quantitative deficiency of NK and B cell with normal responses in other immune parameters.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IDS antibodyPathways associated with anti-IDS antibody
 Reference Product  PubMed Publications
 IDUA antibody  >6 publications with IDS and IDUA
 ARSB antibody  >4 publications with IDS and ARSB
 HEXA antibody  >2 publications with IDS and HEXA
 SUMF1 antibody  >1 publications with IDS and SUMF1
 HPSE antibody  >1 publications with IDS and HPSE
 NAGLU antibody  >1 publications with IDS and NAGLU
 Products by Pathway  Pathway Diagram
 CS/DS Degradation Pathway antibodies  CS/DS Degradation Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Defective B3GAT3 Causes JDSSDHD Pathway antibodies  Defective B3GAT3 Causes JDSSDHD Pathway Diagram
 Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway antibodies  Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway Diagram
 Defective B4GALT7 Causes EDS, Progeroid Type Pathway antibodies  Defective B4GALT7 Causes EDS, Progeroid Type Pathway Diagram
 Defective CHST14 Causes EDS, Musculocontractural Type Pathway antibodies  Defective CHST14 Causes EDS, Musculocontractural Type Pathway Diagram
 Defective CHST3 Causes SEDCJD Pathway antibodies  Defective CHST3 Causes SEDCJD Pathway Diagram
 Defective CHST6 Causes MCDC1 Pathway antibodies  Defective CHST6 Causes MCDC1 Pathway Diagram
 Defective CHSY1 Causes TPBS Pathway antibodies  Defective CHSY1 Causes TPBS Pathway Diagram
 Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway antibodies  Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway Diagram
Diseases associated with anti-IDS antibodyOrgans/Tissues associated with anti-IDS antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >381 publications with IDS and Nervous System Diseases
 Mucopolysaccharidosis II Antibodies  >203 publications with IDS and Mucopolysaccharidosis II
 Ovarian Neoplasms Antibodies  >57 publications with IDS and Ovarian Neoplasms
 Ovarian Diseases Antibodies  >57 publications with IDS and Ovarian Diseases
 Brain Diseases Antibodies  >54 publications with IDS and Brain Diseases
 Inflammation Antibodies  >49 publications with IDS and Inflammation
 Congenital Abnormalities Antibodies  >42 publications with IDS and Congenital Abnormalities
 Kidney Diseases Antibodies  >38 publications with IDS and Kidney Diseases
 Disease Models, Animal Antibodies  >36 publications with IDS and Disease Models, Animal
 Liver Diseases Antibodies  >27 publications with IDS and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >350 publications with IDS and Blood
 Brain Antibodies  >112 publications with IDS and Brain
 Bone Antibodies  >95 publications with IDS and Bone
 Heart Antibodies  >67 publications with IDS and Heart
 Muscle Antibodies  >59 publications with IDS and Muscle
 Liver Antibodies  >54 publications with IDS and Liver
 Kidney Antibodies  >47 publications with IDS and Kidney
 Vascular Antibodies  >40 publications with IDS and Vascular
 Mouth Antibodies  >35 publications with IDS and Mouth
 Skin Antibodies  >33 publications with IDS and Skin
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