NP_001229852.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 67 kDa Predicted: 67 kDa
NCBI Official Full Name
eukaryotic translation initiation factor 3 subunit L isoform 2
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 3 subunit L
NCBI Official Synonym Symbols
EIF3EIP; EIF3S11; HSPC021; HSPC025; MSTP005; EIF3S6IP [Similar Products]
NCBI Protein Information
eukaryotic translation initiation factor 3 subunit L
UniProt Protein Name
Eukaryotic translation initiation factor 3 subunit L
UniProt Synonym Protein Names
Eukaryotic translation initiation factor 3 subunit 6-interacting proteinUniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03011; Eukaryotic translation initiation factor 3 subunit E-interacting proteinUniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03011
UniProt Synonym Gene Names
EIF3EIPUniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03011; EIF3S6IPUniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03011; eIF3l [Similar Products]
UniProt Comments for IF3EI
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
Research Articles on IF3EI
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Products associated with anti-IF3EI antibody
Diseases associated with anti-IF3EI antibody
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