NP_001538.4
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
54,632 Da
NCBI Official Full Name
interferon-induced protein with tetratricopeptide repeats 2
NCBI Official Synonym Full Names
interferon-induced protein with tetratricopeptide repeats 2
NCBI Official Synonym Symbols
P54; G10P2; IFI54; ISG54; cig42; IFI-54; IFIT-2; GARG-39; IFI-54K; ISG-54K; ISG-54 K [Similar Products]
NCBI Protein Information
interferon-induced protein with tetratricopeptide repeats 2; Interferon, alpha-inducible protein (MW 54kD); interferon-induced 54 kDa protein; interferon-induced protein 54
UniProt Protein Name
Interferon-induced protein with tetratricopeptide repeats 2
UniProt Synonym Protein Names
ISG-54 K; Interferon-induced 54 kDa protein; IFI-54K; P54
UniProt Synonym Gene Names
UniProt Entry Name
IFIT2_HUMAN
UniProt Comments for IFIT2
IFIT2: IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism). Can promote apoptosis. Belongs to the IFIT family.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 10q23.31
Cellular Component: endoplasmic reticulum; cytoplasm; cytosol
Molecular Function: protein binding
Biological Process: apoptotic mitochondrial changes; positive regulation of apoptosis; cytokine and chemokine mediated signaling pathway; response to virus; negative regulation of protein binding; defense response to virus
Research Articles on IFIT2
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Products associated with anti-IFIT2 antibody
Pathways associated with anti-IFIT2 antibody
Diseases associated with anti-IFIT2 antibody
Organs/Tissues associated with anti-IFIT2 antibody
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