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anti-IFNAR1 antibody :: Rabbit anti-Human IFNAR1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2517323
Testing Data
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IFNAR1, Polyclonal Antibody

★Popular Item★
 Also Known As   

IFNAR1 Antibody

 Product Synonym Names    AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC
 Product Gene Name   

anti-IFNAR1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    107450
 3D Structure    ModBase 3D Structure for BC021825
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen affinity purification
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 Immunogen    Fusion protein of IFNAR1
 Calculated Molecular Weight    557aa; 64kd
 Observed Molecular Weight    64kd
 Buffer    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-845
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-IFNAR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-IFNAR1 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-IFNAR1 antibody    WB: 1:500-1:5000
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 Testing Data of anti-IFNAR1 antibody    A431 cells were subjected to SDS-PAGE followed by western Blot with IFNAR1 antibody at dilution of 1:600
anti-IFNAR1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for IFNAR1. It may not necessarily be applicable to this product.
 NCBI GI #    46488932
 NCBI GeneID    3454
 NCBI Accession #    NP_000620.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000629.2 [Other Products]
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 UniProt Primary Accession #    BC021825 [Other Products]
 UniProt Secondary Accession #    Q53GW9; Q53H11; Q6PKD7; Q7M4L2; Q8WTZ2; B2R6L9; B4DNT3; D3DSF0 [Other Products]
 UniProt Related Accession #    P17181 [Other Products]
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 NCBI Official Full Name    interferon alpha/beta receptor 1
 NCBI Official Synonym Full Names    interferon (alpha, beta and omega) receptor 1
 NCBI Official Symbol    IFNAR1 [Similar Products]
 NCBI Official Synonym Symbols   
AVP; IFRC; IFNAR; IFNBR; IFN-alpha-REC
[Similar Products]
 NCBI Protein Information    interferon alpha/beta receptor 1; CRF2-1; IFN-R-1; IFN-alpha/beta receptor 1; alpha-type antiviral protein; beta-type antiviral protein; cytokine receptor class-II member 1; cytokine receptor family 2 member 1; interferon-alpha/beta receptor alpha chain; interferon-beta receptor 1; type I interferon receptor 1
 UniProt Protein Name    Interferon alpha/beta receptor 1
 UniProt Synonym Protein Names   
Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; Type I interferon receptor 1
 Protein Family    Interferon alpha/beta receptor
 UniProt Gene Name    IFNAR1 [Similar Products]
 UniProt Synonym Gene Names    IFNAR; IFN-R-1; IFN-alpha/beta receptor 1; CRF2-1 [Similar Products]
 UniProt Entry Name    INAR1_HUMAN
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 NCBI Summary for IFNAR1    The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IFNAR1    IFNAR1: receptor for interferons alpha and beta. Belongs to the type II cytokine family of receptors. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Tyk2 tyrosine kinase is essential for stable cell surface expression of IFNAR1. Present in all tissues and even on the surface of most IFN-resistant cells.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: protein binding; interferon receptor activity; interferon-alpha/beta receptor activity

Biological Process: positive regulation of interferon-gamma production; cell surface receptor linked signal transduction; T cell activation; response to virus; cytokine and chemokine mediated signaling pathway; positive regulation of interleukin-1 beta secretion; interferon type I biosynthetic process; JAK-STAT cascade; defense response to virus
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 Research Articles on IFNAR1    1. The crystal structure of a receptor-binding fragment of human TYK2, encompassing the FERM and SH2 domains, in complex with peptide motif from the interferon-alpha receptor chain 1 (IFNAR1) is presented.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IFNAR1 antibodyPathways associated with anti-IFNAR1 antibody
 Reference Product  PubMed Publications
 IFNA2 antibody  >399 publications with IFNAR1 and IFNA2
 IFNAR2 antibody  >156 publications with IFNAR1 and IFNAR2
 TYK2 antibody  >56 publications with IFNAR1 and TYK2
 STAT2 antibody  >53 publications with IFNAR1 and STAT2
 JAK1 antibody  >38 publications with IFNAR1 and JAK1
 STAT3 antibody  >17 publications with IFNAR1 and STAT3
 SOCS1 antibody  >15 publications with IFNAR1 and SOCS1
 IFNB1 antibody  >6 publications with IFNAR1 and IFNB1
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with anti-IFNAR1 antibodyOrgans/Tissues associated with anti-IFNAR1 antibody
 Disease Name  Pubmed Publications
 Virus Diseases Antibodies  >108 publications with IFNAR1 and Virus Diseases
 Inflammation Antibodies  >64 publications with IFNAR1 and Inflammation
 Liver Diseases Antibodies  >48 publications with IFNAR1 and Liver Diseases
 Necrosis Antibodies  >26 publications with IFNAR1 and Necrosis
 Carcinoma, Hepatocellular Antibodies  >13 publications with IFNAR1 and Carcinoma, Hepatocellular
 Cardiovascular Diseases Antibodies  >10 publications with IFNAR1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >9 publications with IFNAR1 and Heart Diseases
 Fever Antibodies  >9 publications with IFNAR1 and Fever
 Kidney Diseases Antibodies  >5 publications with IFNAR1 and Kidney Diseases
 Fibrosis Antibodies  >4 publications with IFNAR1 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >127 publications with IFNAR1 and Blood
 Liver Antibodies  >47 publications with IFNAR1 and Liver
 Bone Antibodies  >41 publications with IFNAR1 and Bone
 Bone Marrow Antibodies  >39 publications with IFNAR1 and Bone Marrow
 Lung Antibodies  >35 publications with IFNAR1 and Lung
 Spleen Antibodies  >25 publications with IFNAR1 and Spleen
 Brain Antibodies  >24 publications with IFNAR1 and Brain
 Lymph Node Antibodies  >13 publications with IFNAR1 and Lymph Node
 Lymph Antibodies  >13 publications with IFNAR1 and Lymph
 Skin Antibodies  >10 publications with IFNAR1 and Skin
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