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anti-IFNGR1 antibody :: Rabbit anti-Human, Mouse IFNGR1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1492592
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IFNGR1, Polyclonal Antibody

 Also Known As   

IFNGR1 Antibody

 Product Synonym Names    IFN-gamma receptor 1; IFN-gamma-R1; CDw119; CD119; IFNGR1
 Product Gene Name   

anti-IFNGR1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    107470
 3D Structure    ModBase 3D Structure for P15260
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Interferon gamma receptor 1 protein (270-489aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-12753 / sc-700 / sc-25481
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-IFNGR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-IFNGR1 antibody

   Receptor for interferon gamma. Two receptors bind one interferon gamma dimer.
 Applications Tested/Suitable for anti-IFNGR1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-IFNGR1 antibody    Recommended dilution: WB:1:200-1000
IHC:1:20-1:200
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 Western Blot (WB) of anti-IFNGR1 antibody    Western blot
All lanes:IFNGR1 antibody at 2ug/ml+mouse lung tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 55,22 kDa
Observed band size: 54 kDa

anti-IFNGR1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-IFNGR1 antibody    Immunohistochemistry of paraffin-embedded human breast cancer at dilution 1:100
anti-IFNGR1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-IFNGR1 antibody    Immunohistochemistry of paraffin-embedded human small intestine at dilution 1:100
anti-IFNGR1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-IFNGR1 antibody    Immunohistochemistry of paraffin-embedded human pancreas tissue at dilution 1:100
anti-IFNGR1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for IFNGR1. It may not necessarily be applicable to this product.
 NCBI GI #    4557880
 NCBI GeneID    3459
 NCBI Accession #    NP_000407.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000416.2 [Other Products]
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 UniProt Primary Accession #    P15260 [Other Products]
 UniProt Secondary Accession #    Q53Y96; B4DFT7; E1P587 [Other Products]
 UniProt Related Accession #    P15260 [Other Products]
 Molecular Weight    21,542 Da
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 NCBI Official Full Name    interferon gamma receptor 1
 NCBI Official Synonym Full Names    interferon gamma receptor 1
 NCBI Official Symbol    IFNGR1 [Similar Products]
 NCBI Official Synonym Symbols   
CD119; IFNGR; IMD27A; IMD27B
[Similar Products]
 NCBI Protein Information    interferon gamma receptor 1
 UniProt Protein Name    Interferon gamma receptor 1
 UniProt Synonym Protein Names   
CDw119; CD_antigen: CD119
 Protein Family    Interferon gamma receptor
 UniProt Gene Name    IFNGR1 [Similar Products]
 UniProt Synonym Gene Names    IFN-gamma receptor 1; IFN-gamma-R1 [Similar Products]
 UniProt Entry Name    INGR1_HUMAN
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 NCBI Summary for IFNGR1    This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IFNGR1    IFNGR1: Receptor for interferon gamma. Two receptors bind one interferon gamma dimer. Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD); also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. Belongs to the type II cytokine receptor family.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 6q23.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: interferon-gamma receptor activity; interleukin-20 binding; protein binding

Biological Process: cytokine and chemokine mediated signaling pathway; response to virus; signal transduction

Disease: Helicobacter Pylori Infection, Susceptibility To; Hepatitis B Virus, Susceptibility To; Immunodeficiency 27a; Immunodeficiency 27b; Mycobacterium Tuberculosis, Susceptibility To
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 Research Articles on IFNGR1    1. Statistical analyses revealed that four genetic variants in IFNGR1 were marginally associated with the risk of Tuberculosis (P = 0.02-0.04), while other single nucleotide polymorphisms in IFNGR1 and IFNGR2 did not exhibit any associations
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IFNGR1 antibodyPathways associated with anti-IFNGR1 antibody
 Reference Product  PubMed Publications
 IFNGR2 antibody  >55 publications with IFNGR1 and IFNGR2
 STAT1 antibody  >52 publications with IFNGR1 and STAT1
 IFNG antibody  >33 publications with IFNGR1 and IFNG
 JAK1 antibody  >9 publications with IFNGR1 and JAK1
 JAK2 antibody  >8 publications with IFNGR1 and JAK2
 SOCS1 antibody  >3 publications with IFNGR1 and SOCS1
 SOCS3 antibody  >2 publications with IFNGR1 and SOCS3
 Products by Pathway  Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 IFN-gamma Pathway antibodies  IFN-gamma Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with anti-IFNGR1 antibodyOrgans/Tissues associated with anti-IFNGR1 antibody
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >23 publications with IFNGR1 and Lung Diseases
 Inflammation Antibodies  >19 publications with IFNGR1 and Inflammation
 Necrosis Antibodies  >16 publications with IFNGR1 and Necrosis
 MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO Antibodies  >14 publications with IFNGR1 and MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO
 Mycobacterium Infections, Nontuberculous Antibodies  >11 publications with IFNGR1 and Mycobacterium Infections, Nontuberculous
 Helicobacter Infections Antibodies  >6 publications with IFNGR1 and Helicobacter Infections
 Liver Diseases Antibodies  >5 publications with IFNGR1 and Liver Diseases
 Fibrosis Antibodies  >2 publications with IFNGR1 and Fibrosis
 Kidney Diseases Antibodies  >2 publications with IFNGR1 and Kidney Diseases
 Neoplasms, Experimental Antibodies  >2 publications with IFNGR1 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >50 publications with IFNGR1 and Blood
 Liver Antibodies  >9 publications with IFNGR1 and Liver
 Bone Antibodies  >9 publications with IFNGR1 and Bone
 Spleen Antibodies  >8 publications with IFNGR1 and Spleen
 Kidney Antibodies  >7 publications with IFNGR1 and Kidney
 Lung Antibodies  >7 publications with IFNGR1 and Lung
 Stomach Antibodies  >6 publications with IFNGR1 and Stomach
 Brain Antibodies  >5 publications with IFNGR1 and Brain
 Lymph Node Antibodies  >4 publications with IFNGR1 and Lymph Node
 Embryonic Tissue Antibodies  >3 publications with IFNGR1 and Embryonic Tissue
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