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anti-IFNGR2 antibody :: Rabbit anti-Human IFNGR2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2516459
Testing Data
Unit / Price
0.06 mL  /  $195 +1 FREE 8GB USB
0.12 mL  /  $270 +1 FREE 8GB USB
0.2 mL  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IFNGR2, Polyclonal Antibody

 Also Known As   

IFNGR2 Antibody

 Product Synonym Names    AF-1; IFGR2; IFNGT1
 Product Gene Name   

anti-IFNGR2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147569
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen affinity purification
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 Immunogen    Fusion protein of IFNGR2
 Calculated Molecular Weight: 45kd
Observed Molecular Weight: 55kd
  
 Buffer    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-53589 / sc-53588 / sc-30012 / sc-971 / sc-970
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles
 Other Notes    Small volumes of anti-IFNGR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-IFNGR2 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-IFNGR2 antibody    WB: 1:200-1:2000
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 Testing Data of anti-IFNGR2 antibody    anti-IFNGR2 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for IFNGR2. It may not necessarily be applicable to this product.
 NCBI GI #    47419934
 NCBI GeneID    3460
 NCBI Accession #    NP_005525.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005534.3 [Other Products]
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 UniProt Secondary Accession #    Q9BTL5 [Other Products]
 UniProt Related Accession #    P38484 [Other Products]
 Molecular Weight    37,806 Da
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 NCBI Official Full Name    interferon gamma receptor 2
 NCBI Official Synonym Full Names    interferon gamma receptor 2 (interferon gamma transducer 1)
 NCBI Official Symbol    IFNGR2 [Similar Products]
 NCBI Official Synonym Symbols   
AF-1; IFGR2; IMD28; IFNGT1
[Similar Products]
 NCBI Protein Information    interferon gamma receptor 2; IFN-gamma receptor 2; IFN-gamma-R2; interferon gamma receptor accessory factor 1; interferon gamma receptor accessory factor-1; interferon gamma receptor beta chain; interferon gamma transducer 1
 UniProt Protein Name    Interferon gamma receptor 2
 UniProt Synonym Protein Names   
Interferon gamma receptor accessory factor 1; AF-1; Interferon gamma transducer 1
 Protein Family    Interferon gamma receptor
 UniProt Gene Name    IFNGR2 [Similar Products]
 UniProt Synonym Gene Names    IFNGT1; IFN-gamma receptor 2; IFN-gamma-R2; AF-1 [Similar Products]
 UniProt Entry Name    INGR2_HUMAN
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 NCBI Summary for IFNGR2    This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IFNGR2    IFNGR2: Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD); also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. Belongs to the type II cytokine receptor family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: endoplasmic reticulum; integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interferon-gamma receptor activity

Biological Process: cell surface receptor linked signal transduction; response to virus; cytokine and chemokine mediated signaling pathway

Disease: Immunodeficiency 28
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 Research Articles on IFNGR2    1. It related to persistence of hepatitis B virus (HBV) infection and viral load in chronic HBV.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IFNGR2 antibodyPathways associated with anti-IFNGR2 antibody
 Reference Product  PubMed Publications
 IFNGR1 antibody  >47 publications with IFNGR2 and IFNGR1
 STAT1 antibody  >27 publications with IFNGR2 and STAT1
 JAK2 antibody  >7 publications with IFNGR2 and JAK2
 JAK1 antibody  >4 publications with IFNGR2 and JAK1
 Products by Pathway  Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
Diseases associated with anti-IFNGR2 antibodyOrgans/Tissues associated with anti-IFNGR2 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >10 publications with IFNGR2 and Inflammation
 Mycobacterium Infections, Nontuberculous Antibodies  >8 publications with IFNGR2 and Mycobacterium Infections, Nontuberculous
 Liver Diseases Antibodies  >7 publications with IFNGR2 and Liver Diseases
 Necrosis Antibodies  >6 publications with IFNGR2 and Necrosis
 Breast Neoplasms Antibodies  >6 publications with IFNGR2 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >4 publications with IFNGR2 and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with IFNGR2 and Carcinoma, Hepatocellular
 Thrombocytopenia Antibodies  >2 publications with IFNGR2 and Thrombocytopenia
 Heart Diseases Antibodies  >2 publications with IFNGR2 and Heart Diseases
 Neoplasms, Experimental Antibodies  >2 publications with IFNGR2 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >29 publications with IFNGR2 and Blood
 Liver Antibodies  >8 publications with IFNGR2 and Liver
 Kidney Antibodies  >5 publications with IFNGR2 and Kidney
 Skin Antibodies  >5 publications with IFNGR2 and Skin
 Prostate Antibodies  >4 publications with IFNGR2 and Prostate
 Muscle Antibodies  >3 publications with IFNGR2 and Muscle
 Vascular Antibodies  >3 publications with IFNGR2 and Vascular
 Brain Antibodies  >3 publications with IFNGR2 and Brain
 Lymph Node Antibodies  >2 publications with IFNGR2 and Lymph Node
 Thyroid Antibodies  >2 publications with IFNGR2 and Thyroid
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