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anti-IFNLR1 antibody :: Rabbit anti-Human, Mouse IFNLR1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7045831
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IFNLR1, Polyclonal Antibody

★Popular Item★
 Also Known As   

IFNLR1 Antibody

 Product Synonym Names    Interferon lambda receptor 1; IFN-lambda receptor 1; IFN-lambda-R1; Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12; CRF2-12; Interleukin-28 receptor subunit alpha; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; Likely interleukin or cytokine receptor 2; LICR2; IFNLR1; IL28RA; LICR2
 Product Gene Name   

anti-IFNLR1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS7045831 Technical Datasheet    Technical Datasheet PDF
 OMIM    607404
 3D Structure    ModBase 3D Structure for Q8IU57
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Interferon lambda receptor 1 protein (21-228AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-66541 / sc-66542 / sc-135101
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-IFNLR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IFNLR1 antibody

   The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.
 Applications Tested/Suitable for anti-IFNLR1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-IFNLR1 antibody    Western blot
All lanes: IFNLR1antibody at 3.04ug/ml
Lane 1: Mouse kidney tissue
Lane 2: Mouse liver tissue
Lane 3: Human placenta tissue
Lane 4: Mouse lung tissue
Lane 5: Jurkat whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 58,55,24,28 kDa
Observed band size: 58 kDa

anti-IFNLR1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-IFNLR1 antibody    Immunohistochemistry of paraffin-embedded human testis tissue MBS7045831 at dilution 1:100
anti-IFNLR1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-IFNLR1 antibody    Immunohistochemistry of paraffin-embedded human adrenal gland tissue MBS7045831 at dilution 1:100
anti-IFNLR1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for IFNLR1. It may not necessarily be applicable to this product.
 NCBI GI #    25014103
 NCBI GeneID    163702
 NCBI Accession #    NP_734464.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_170743.3 [Other Products]
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 UniProt Primary Accession #    Q8IU57 [Other Products]
 UniProt Secondary Accession #    Q5VTX5; Q5VTX7; Q5VTX8; Q6ZML8; Q8IV66; Q8IZI7; Q8IZI8 [Other Products]
 UniProt Related Accession #    Q8IU57 [Other Products]
 Molecular Weight    27,536 Da
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 NCBI Official Full Name    interferon lambda receptor 1 isoform 1
 NCBI Official Synonym Full Names    interferon lambda receptor 1
 NCBI Official Symbol    IFNLR1 [Similar Products]
 NCBI Official Synonym Symbols   
IFNLR; LICR2; IL28RA; CRF2/12; IL-28R1
[Similar Products]
 NCBI Protein Information    interferon lambda receptor 1
 UniProt Protein Name    Interferon lambda receptor 1
 UniProt Synonym Protein Names   
Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12; CRF2-12; Interleukin-28 receptor subunit alpha; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; Likely interleukin or cytokine receptor 2; LICR2
 Protein Family    Interferon lambda receptor
 UniProt Gene Name    IFNLR1 [Similar Products]
 UniProt Synonym Gene Names    IL28RA; LICR2; IFN-lambda receptor 1; IFN-lambda-R1; CRF2-12; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; LICR2 [Similar Products]
 UniProt Entry Name    INLR1_HUMAN
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 NCBI Summary for IFNLR1    The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IFNLR1    IL28RA: The IL28RA/IL10RB dimer is a receptor for IL28A, IL28B and IL29. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the type II cytokine receptor family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: interleukin-28 receptor complex; plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding

Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; mucosal immune response; regulation of defense response to virus by host
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 Research Articles on IFNLR1    1. Selective expression of IFNlambdaR1 was considered to be a plus point towards the targeted anti-viral activity of IFNlambdas but artificial control on its expression will surely make IFNlambdas a better drug with enhanced activity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-IFNLR1 antibodyDiseases associated with anti-IFNLR1 antibody
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Signaling By Interleukins Pathway antibodies  Signaling By Interleukins Pathway Diagram
 Type III Interferon Signaling Pathway antibodies  Type III Interferon Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >8 publications with IFNLR1 and Liver Diseases
 Lung Diseases Antibodies  >3 publications with IFNLR1 and Lung Diseases
 Carcinoma Antibodies  >2 publications with IFNLR1 and Carcinoma
 Carcinoma, Hepatocellular Antibodies  >2 publications with IFNLR1 and Carcinoma, Hepatocellular
 Nervous System Diseases Antibodies  >2 publications with IFNLR1 and Nervous System Diseases
 Liver Neoplasms Antibodies  >1 publications with IFNLR1 and Liver Neoplasms
 Fibrosis Antibodies  >1 publications with IFNLR1 and Fibrosis
 Fatty Liver Antibodies  >1 publications with IFNLR1 and Fatty Liver
 Lung Neoplasms Antibodies  >1 publications with IFNLR1 and Lung Neoplasms
 Hyperplasia Antibodies  >1 publications with IFNLR1 and Hyperplasia
Organs/Tissues associated with anti-IFNLR1 antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >4 publications with IFNLR1 and Lung
 Lymph Antibodies  >2 publications with IFNLR1 and Lymph
 Lymph Node Antibodies  >2 publications with IFNLR1 and Lymph Node
 Intestine Antibodies  >1 publications with IFNLR1 and Intestine
 Prostate Antibodies  >1 publications with IFNLR1 and Prostate
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