NP_734464.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
interferon lambda receptor 1 isoform 1
NCBI Official Synonym Full Names
interferon lambda receptor 1
NCBI Official Synonym Symbols
IFNLR; LICR2; IL28RA; CRF2/12; IL-28R1 [Similar Products]
NCBI Protein Information
interferon lambda receptor 1
UniProt Protein Name
Interferon lambda receptor 1
UniProt Synonym Protein Names
Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12; CRF2-12; Interleukin-28 receptor subunit alpha; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; Likely interleukin or cytokine receptor 2; LICR2
UniProt Synonym Gene Names
IL28RA; LICR2; IFN-lambda receptor 1; IFN-lambda-R1; CRF2-12; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; LICR2 [Similar Products]
UniProt Entry Name
INLR1_HUMAN
NCBI Summary for IFNLR1
The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
UniProt Comments for IFNLR1
IL28RA: The IL28RA/IL10RB dimer is a receptor for IL28A, IL28B and IL29. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the type II cytokine receptor family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component: interleukin-28 receptor complex; plasma membrane
Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding
Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; mucosal immune response; regulation of defense response to virus by host
Research Articles on IFNLR1
Precautions
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Pathways associated with anti-IFNLR1 antibody
Diseases associated with anti-IFNLR1 antibody
Organs/Tissues associated with anti-IFNLR1 antibody
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