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anti-IFT122 antibody :: Rabbit IFT122 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2528395 anti-IFT122 antibody
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 Product Name   

IFT122, Polyclonal Antibody

 Also Known As   

IFT122 Antibody

 Product Synonym Names    SPG; WDR10; WDR10p; WDR140
 Product Gene Name   

anti-IFT122 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    218330
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
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 Immunogen    Fusion protein of IFT122
 Calculated Molecular Weight: 142kd   
 Buffer    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-IFT122 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-IFT122 antibody   


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NCBI/Uniprot data below describe general gene information for IFT122. It may not necessarily be applicable to this product.
 NCBI GI #    526253060
 NCBI GeneID    55764
 NCBI Accession #    NP_001267475.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001280546.1 [Other Products]
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 UniProt Secondary Accession #    Q53G36; Q8TC06; Q9BTB9; B3KW53; B4DEY9; B4DPW7; E7EQF4; E9PDG2; E9PDX2; G3XAB1; H7C3C0 [Other Products]
 UniProt Related Accession #    Q9HBG6 [Other Products]
 Molecular Weight    113,230 Da
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 NCBI Official Full Name    intraflagellar transport protein 122 homolog isoform 7
 NCBI Official Synonym Full Names    intraflagellar transport 122
 NCBI Official Symbol    IFT122 [Similar Products]
 NCBI Official Synonym Symbols   
CED; SPG; CED1; WDR10; WDR10p; WDR140
[Similar Products]
 NCBI Protein Information    intraflagellar transport protein 122 homolog; WD repeat domain 10; WD repeat-containing protein 10; WD repeat-containing protein 140; intraflagellar transport 122 homolog
 UniProt Protein Name    Intraflagellar transport protein 122 homolog
 UniProt Synonym Protein Names   
WD repeat-containing protein 10; WD repeat-containing protein 140
 Protein Family    Intraflagellar transport protein
 UniProt Gene Name    IFT122 [Similar Products]
 UniProt Synonym Gene Names    SPG; WDR10; WDR140 [Similar Products]
 UniProt Entry Name    IF122_HUMAN
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 NCBI Summary for IFT122    This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Mutations in this gene cause cranioectodermal dysplasia-1. A related pseudogene is located on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
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 UniProt Comments for IFT122    IFT122: Required for cilia formation and Shh signaling during neuronal patterning. Defects in IFT122 are a cause of cranioectodermal dysplasia type 1 (CED1). CED1 is a disorder characterized by craniofacial, skeletal and ectodermal abnormalities. Clinical features include dolichocephaly (with or without sagittal suture synostosis), scaphocephaly, short stature, limb shortening, short ribs, narrow chest, brachydactyly, renal failure and hepatic fibrosis, small and abnormally shaped teeth, sparse hair, skin laxity and abnormal nails. 4 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 3q21

Cellular Component: membrane; cytoplasm; photoreceptor connecting cilium; cilium

Molecular Function: protein binding

Biological Process: limb development; embryonic forelimb morphogenesis; organelle organization and biogenesis; signal transduction downstream of smoothened; embryonic body morphogenesis; camera-type eye morphogenesis; negative regulation of smoothened signaling pathway; neural tube closure; cilium biogenesis; embryonic heart tube development; embryonic digit morphogenesis; negative regulation of smoothened signaling pathway in ventral spinal cord patterning; negative regulation of epithelial cell proliferation

Disease: Cranioectodermal Dysplasia 1
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 Research Articles on IFT122    1. this study was able to find causative IFT122 mutations in a non-consanguineous family with recurrent abortions.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-IFT122 antibodyDiseases associated with anti-IFT122 antibody
 Products by Pathway  Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Hedgehog 'off' State Pathway antibodies  Hedgehog 'off' State Pathway Diagram
 Intraflagellar Transport Pathway antibodies  Intraflagellar Transport Pathway Diagram
 Organelle Biogenesis And Maintenance Pathway antibodies  Organelle Biogenesis And Maintenance Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Hedgehog Pathway antibodies  Signaling By Hedgehog Pathway Diagram
 Disease Name  Pubmed Publications
 Cranioectodermal Dysplasia Antibodies  >4 publications with IFT122 and Cranioectodermal Dysplasia
 Congenital Abnormalities Antibodies  >2 publications with IFT122 and Congenital Abnormalities
 Fibrosis Antibodies  >1 publications with IFT122 and Fibrosis
 Hemorrhage Antibodies  >1 publications with IFT122 and Hemorrhage
 Ciliary Motility Disorders Antibodies  >1 publications with IFT122 and Ciliary Motility Disorders
 Craniosynostoses Antibodies  >1 publications with IFT122 and Craniosynostoses
Organs/Tissues associated with anti-IFT122 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with IFT122 and Brain
 Skin Antibodies  >2 publications with IFT122 and Skin
 Connective Tissue Antibodies  >2 publications with IFT122 and Connective Tissue
 Bone Antibodies  >2 publications with IFT122 and Bone
 Thyroid Antibodies  >1 publications with IFT122 and Thyroid
 Liver Antibodies  >1 publications with IFT122 and Liver
 Embryonic Tissue Antibodies  >1 publications with IFT122 and Embryonic Tissue
 Testis Antibodies  >1 publications with IFT122 and Testis
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