NP_060480.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,108 Da
NCBI Official Full Name
intraflagellar transport protein 57 homolog
NCBI Official Synonym Full Names
intraflagellar transport 57
NCBI Protein Information
intraflagellar transport protein 57 homolog
UniProt Protein Name
Intraflagellar transport protein 57 homolog
UniProt Synonym Protein Names
Dermal papilla-derived protein 8; Estrogen-related receptor beta-like protein 1; HIP1-interacting protein; MHS4R2
UniProt Synonym Gene Names
UniProt Entry Name
IFT57_HUMAN
UniProt Comments for IFT57
IFT57: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. Belongs to the IFT57 family.
Chromosomal Location of Human Ortholog: 3q13.13
Cellular Component: axoneme; centrosome; cilium; Golgi apparatus; photoreceptor connecting cilium
Molecular Function: DNA binding; protein binding
Biological Process: apoptosis; caspase activation; cilium biogenesis; heart looping; intraflagellar transport; negative regulation of epithelial cell proliferation; neural tube closure; organelle organization and biogenesis; regulation of apoptosis; regulation of transcription, DNA-dependent; smoothened signaling pathway; transcription, DNA-dependent
Research Articles on IFT57
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Products associated with anti-IFT57 antibody
Pathways associated with anti-IFT57 antibody
Diseases associated with anti-IFT57 antibody
Organs/Tissues associated with anti-IFT57 antibody
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