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anti-IGF-II antibody :: Rabbit IGF-II Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS551011
Unit / Price
0.1 mg  /  $280 +1 FREE 8GB USB
0.2 mg  /  $385 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IGF-II, Polyclonal Antibody

 Also Known As   

Rabbit anti IGF-II Polyclonal

 Product Synonym Names    Rabbit anti Human IGF-II Polyclonal purified; IGF2; IGF-2; igf-ii; pab; polyclonal
 Product Gene Name   

anti-IGF-II antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147470
 3D Structure    ModBase 3D Structure for P01344
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    >95% purity. Serum IgG fraction was purified by Protein A affinity chromatography.
 Form/Format    0.2um filtered 1 mg/ml solution in TBS pH 7.4, 50% glycerol, 1% BSA, 0.03% proclin.
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 Source Note    Polyclonal IGF-II antibody was produced from sera of rabbits immunized with synthetic protein containing IGF-2 antigenic determinants.
 Reconstitution    A quick spin of the vial followed by reconstitution in 0.01M PBS pH 7.4 or other diluents.
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 Preparation and Storage    This antibody can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for 12 months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-IGF-II antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-IGF-II antibody

   IGF-1 and IGF-2 are members of a protein family of related proteins with hormonal activities including nerve growth factor.Cell types responding to the two IGF factors include adipocytes, chondrocytes, epithelial cells, fibroblasts, glial cells, hepatocytes, muscle cells, and osteoblasts. The IGF-2 receptor, CD222, is a single-chain protein of 250 kDa. It is a high affinity binding protein for IGF-2 and shows very low affinity for IGF-1 and none for insulin. The cytoplasmic domain of the receptor does not possess intrinsic tyrosine kinase activity.
 Product Categories/Family for anti-IGF-II antibody    Polyclonal
 Applications Tested/Suitable for anti-IGF-II antibody   

Western Blot (WB), IHC (Immunohistochemistry), ELISA (EIA)

 Application Notes for anti-IGF-II antibody    ELISA: Use at a concentration range of 1-2ug/ml.
Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 ug/ml.
IHC: A suitable range of concentrations of this antibody for IHC is 2-10 ug/ml.
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 Immunohistochemistry of anti-IGF-II antibody    Immunohistochemical analysis of IGF-II expression in human ovarian vascular endothelial cells.
It was used as primary antibody, dilution 1:200, DAB chromogenic substrate
anti-IGF-II antibody Immunohistochemistry (IHC) image
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 Immunohistochemistry #2 of anti-IGF-II antibody    Immunohistochemical analysis of IGF-II expression in human breast carcinoma tissue.
It was used as primary antibody, dilution 1:200.
anti-IGF-II antibody Immunohistochemistry #2 (IHC) image
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NCBI/Uniprot data below describe general gene information for IGF-II. It may not necessarily be applicable to this product.
 NCBI GI #    4504609
 NCBI GeneID    3481
 NCBI Accession #    NP_000603.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000612.4 [Other Products]
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 UniProt Primary Accession #    P01344 [Other Products]
 UniProt Secondary Accession #    P78449; Q14299; Q1WM26; Q9UC68; Q9UC69; B3KX48; B7WP08; C9JAF2; E3UN45 [Other Products]
 UniProt Related Accession #    P01344 [Other Products]
 Molecular Weight    20,140 Da
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 NCBI Official Full Name    insulin-like growth factor II isoform 1 preproprotein
 UniProt Protein Name    Insulin-like growth factor II
 UniProt Synonym Protein Names   
Somatomedin-A
 UniProt Gene Name    IGF2 [Similar Products]
 UniProt Synonym Gene Names    IGF-II [Similar Products]
 UniProt Entry Name    IGF2_HUMAN
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 NCBI Summary for IGF-II    This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
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 UniProt Comments for IGF-II    IGF2: The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development. Epigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SRS). A clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. The phenotypic expression changes during childhood and adolescence, with the facial features and asymmetry usually becoming more subtle with age. Belongs to the insulin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: extracellular space; extracellular region; plasma membrane

Molecular Function: insulin-like growth factor receptor binding; protein serine/threonine kinase activator activity; protein binding; growth factor activity; hormone activity; receptor activator activity; insulin receptor binding

Biological Process: positive regulation of catalytic activity; response to nicotine; genetic imprinting; multicellular organismal development; positive regulation of glycogen biosynthetic process; exocrine pancreas development; female pregnancy; positive regulation of activated T cell proliferation; response to estradiol stimulus; response to radiation; platelet degranulation; positive regulation of MAPKKK cascade; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; skeletal development; response to drug; response to nutrient levels; platelet activation; positive regulation of mitosis; glucose metabolic process; memory; osteoblast differentiation; positive regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; organ morphogenesis; response to ethanol; cellular protein metabolic process; insulin receptor signaling pathway; striated muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of insulin receptor signaling pathway; positive regulation of protein amino acid phosphorylation; blood coagulation

Disease: Silver-russell Syndrome; Growth Restriction, Severe, With Distinctive Facies; Beckwith-wiedemann Syndrome; Wilms Tumor 1
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Product References and Citations for anti-IGF-II antibody

   cell surface-bound il-1 is an upstream regulator of the senescence-associated il-6/IL-8 cytokine network .PNAS, Sep 2009; 10.1073/pnas.0905299106.
the angiogenic effect of probiotic bacillus polyfermenticus on human intestinal microvascular endothelial cells is mediated by IL-8 .Am J Physiol Gastrointest Liver Physiol, Sep 2009; 10.1152/ajpgi.00204.2009.
IL-8 signaling does not mediate intra-amniotic lps-induced inflammation and maturation in preterm fetal lamb lung .Am J Physiol Lung Cell Mol Physiol, Sep 2009; 297: L512 - L519.
the functional significance behind expressing two IL-8 receptor types on pmn .J. Leukoc. Biol., Sep 2009; 86: 529 - 543.
IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells .J. Immunol., Aug 2009; 183: 2159 - 2166.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IGF-II antibodyPathways associated with anti-IGF-II antibody
 Reference Product  PubMed Publications
 IGF2R antibody  >151 publications with IGF-II and IGF2R
 IGF1R antibody  >88 publications with IGF-II and IGF1R
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Regulation Of Insulin-like Growth Factor (IGF) Activity By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies  Regulation Of Insulin-like Growth Factor (IGF) Activity By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram
Diseases associated with anti-IGF-II antibodyOrgans/Tissues associated with anti-IGF-II antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >521 publications with IGF-II and Neoplasms
 Carcinoma Antibodies  >164 publications with IGF-II and Carcinoma
 Female Urogenital Diseases Antibodies  >149 publications with IGF-II and Female Urogenital Diseases
 Congenital Abnormalities Antibodies  >137 publications with IGF-II and Congenital Abnormalities
 Male Urogenital Diseases Antibodies  >130 publications with IGF-II and Male Urogenital Diseases
 Kidney Diseases Antibodies  >103 publications with IGF-II and Kidney Diseases
 Kidney Neoplasms Antibodies  >100 publications with IGF-II and Kidney Neoplasms
 Growth Disorders Antibodies  >90 publications with IGF-II and Growth Disorders
 Liver Neoplasms Antibodies  >89 publications with IGF-II and Liver Neoplasms
 Adenocarcinoma Antibodies  >87 publications with IGF-II and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >180 publications with IGF-II and Embryonic Tissue
 Kidney Antibodies  >123 publications with IGF-II and Kidney
 Placenta Antibodies  >108 publications with IGF-II and Placenta
 Brain Antibodies  >76 publications with IGF-II and Brain
 Lung Antibodies  >49 publications with IGF-II and Lung
 Pancreas Antibodies  >28 publications with IGF-II and Pancreas
 Eye Antibodies  >9 publications with IGF-II and Eye
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