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anti-IGF2BP1 antibody :: Rabbit IGF2BP1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2524880
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IGF2BP1, Polyclonal Antibody

★Popular Item★
 Also Known As   

IGF2BP1 Polyclonal Antibody

 Product Synonym Names    IMP1, ZBP1, CRDBP, IMP-1, CRD-BP, VICKZ1
 Product Gene Name   

anti-IGF2BP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608288
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    1mg/mL (lot specific)
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 Immunogen    Synthetic peptide of human IGF2BP1
 Calculated Molecular Weight: 63kDa   
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-IGF2BP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IGF2BP1 antibody

   This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene.
 Product Categories/Family for anti-IGF2BP1 antibody    Epigenetics
 Applications Tested/Suitable for anti-IGF2BP1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-IGF2BP1 antibody    WB: 1:500-1:2000
IHC: 1:10-1:50
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 Western Blot (WB) of anti-IGF2BP1 antibody    Western Blot analysis of Human fetal lung tissue using IGF2BP1 Polyclonal Antibody at dilution of 1:500
anti-IGF2BP1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-IGF2BP1 antibody    Immunohistochemistry of paraffin-embedded Human lung cancer using IGF2BP1 Polyclonal Antibody at dilution of 1:25
anti-IGF2BP1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for IGF2BP1. It may not necessarily be applicable to this product.
 NCBI GI #    56237027
 NCBI GeneID    10642
 NCBI Accession #    NP_006537.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_006546.3 [Other Products]
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 UniProt Secondary Accession #    C9JT33 [Other Products]
 UniProt Related Accession #    Q9NZI8 [Other Products]
 Molecular Weight    48,598 Da
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 NCBI Official Full Name    insulin-like growth factor 2 mRNA-binding protein 1 isoform 1
 NCBI Official Synonym Full Names    insulin-like growth factor 2 mRNA binding protein 1
 NCBI Official Symbol    IGF2BP1 [Similar Products]
 NCBI Official Synonym Symbols   
IMP1; ZBP1; CRDBP; IMP-1; CRD-BP; VICKZ1
[Similar Products]
 NCBI Protein Information    insulin-like growth factor 2 mRNA-binding protein 1; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding protein 1; VICKZ family member 1; ZBP-1; coding region determinant-binding protein; zipcode-binding protein 1
 UniProt Protein Name    Insulin-like growth factor 2 mRNA-binding protein 1
 UniProt Synonym Protein Names   
Coding region determinant-binding protein; CRD-BP; IGF-II mRNA-binding protein 1; VICKZ family member 1; Zipcode-binding protein 1; ZBP-1
 Protein Family    Insulin-like growth factor 2 mRNA-binding protein
 UniProt Gene Name    IGF2BP1 [Similar Products]
 UniProt Synonym Gene Names    CRDBP; VICKZ1; ZBP1; IGF2 mRNA-binding protein 1; IMP-1; IMP1; CRD-BP; ZBP-1 [Similar Products]
 UniProt Entry Name    IF2B1_HUMAN
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 NCBI Summary for IGF2BP1    This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
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 UniProt Comments for IGF2BP1    IGF2BP1: a conserved trans-acting factor that can control translation of specific mRNAs in vivo. Contains four K homology (KH) domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the target mRNAs and repressing translation. Target mRNAs include those encoding beta-actin and insulin-like growth factor 2 (IGF2). Tyrosine phosphorylation apparently abolishes translational repression of actin expression by decreasing its binding beta-actin mRNA. May have a role in progression of ovarian cancer. Contains nuclear export signals within the RNA-binding KH2 and KH4 domains. Aberrant expression may interfere with c-myc regulation.

Protein type: Translation; RNA-binding

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: growth cone; lamellipodium; axon; perinuclear region of cytoplasm; stress granule; cytoplasm; dendritic spine; cytosol; ribonucleoprotein complex; nucleus; filopodium

Molecular Function: mRNA binding; protein binding; mRNA 3'-UTR binding; nucleotide binding; translation regulator activity; mRNA 5'-UTR binding

Biological Process: mRNA transport; negative regulation of translation; gene expression; regulation of cytokine biosynthetic process
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 Research Articles on IGF2BP1    1. A 14;17 translocation resulting in an IGH-IGF2BP1 fusion is associated with B acute lymphoblastic leukemia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IGF2BP1 antibodyPathways associated with anti-IGF2BP1 antibody
 Reference Product  PubMed Publications
 IGF2 antibody  >11 publications with IGF2BP1 and IGF2
 MYC antibody  >6 publications with IGF2BP1 and MYC
 DHX9 antibody  >3 publications with IGF2BP1 and DHX9
 ACTB antibody  >2 publications with IGF2BP1 and ACTB
 YBX1 antibody  >2 publications with IGF2BP1 and YBX1
 CD44 antibody  >1 publications with IGF2BP1 and CD44
 SYNCRIP antibody  >1 publications with IGF2BP1 and SYNCRIP
 HNRNPU antibody  >1 publications with IGF2BP1 and HNRNPU
 CTNNB1 antibody  >1 publications with IGF2BP1 and CTNNB1
 Products by Pathway  Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Insulin-like Growth Factor-2 MRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) Bind RNA Pathway antibodies  Insulin-like Growth Factor-2 MRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) Bind RNA Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies  Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
Diseases associated with anti-IGF2BP1 antibodyOrgans/Tissues associated with anti-IGF2BP1 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >4 publications with IGF2BP1 and Liver Diseases
 Carcinoma Antibodies  >4 publications with IGF2BP1 and Carcinoma
 Hepatitis Antibodies  >4 publications with IGF2BP1 and Hepatitis
 Abnormalities, Multiple Antibodies  >2 publications with IGF2BP1 and Abnormalities, Multiple
 Birth Weight Antibodies  >1 publications with IGF2BP1 and Birth Weight
 Infertility, Female Antibodies  >1 publications with IGF2BP1 and Infertility, Female
 Necrosis Antibodies  >1 publications with IGF2BP1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >4 publications with IGF2BP1 and Liver
 Blood Antibodies  >4 publications with IGF2BP1 and Blood
 Brain Antibodies  >2 publications with IGF2BP1 and Brain
 Bone Antibodies  >2 publications with IGF2BP1 and Bone
 Lymph Antibodies  >1 publications with IGF2BP1 and Lymph
 Ovary Antibodies  >1 publications with IGF2BP1 and Ovary
 Lymph Node Antibodies  >1 publications with IGF2BP1 and Lymph Node
 Intestine Antibodies  >1 publications with IGF2BP1 and Intestine
 Muscle Antibodies  >1 publications with IGF2BP1 and Muscle
 Placenta Antibodies  >1 publications with IGF2BP1 and Placenta
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