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anti-IGF2BP2 antibody :: Goat IGF2BP2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS623041 anti-IGF2BP2 antibody
Unit / Price
0.1 mg  /  $560 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IGF2BP2, Polyclonal Antibody

 Also Known As   

IGF2BP2 (Insulin-like growth factor 2 mRNA binding protein 2, MP-2, IMP2, VICKZ2, p62, IGF II mRNA binding protein 2)

 Product Synonym Names    Anti -IGF2BP2 (Insulin-like growth factor 2 mRNA binding protein 2, MP-2, IMP2, VICKZ2, p62, IGF II mRNA binding protein 2)
 Product Gene Name   

anti-IGF2BP2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (185361527..185542827, complement). Location: 3q27.2
 OMIM    608289
 3D Structure    ModBase 3D Structure for Q9Y6M1
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Canine, Human, Mouse
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 Specificity    Recognizes human IGF2BP2. Species Crossreactivity: mouse, canine.
 Purity/Purification    Affinity Purified
Purified by affinity chromatography.
 Form/Format    Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
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 Immunogen    A synthetic peptide from the C-terminus of aa-KQQEQKYPQGVASQR.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-IGF2BP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-IGF2BP2 antibody    Antibodies; Abs to Growth Factors, Cytokines
 Applications Tested/Suitable for anti-IGF2BP2 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-IGF2BP2 antibody    Suitable for use in ELISA, Western Blot.
Dilution: Peptide ELISA: 1:16,000.
Western Blot: 1-3ug/ml. A band is detected at ~60-70kD in lysates of cell line HepG2 (calculated MW of 66.1kD according to NP_006539.3). Optimal dilutions to be determined by the researcher.
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NCBI/Uniprot data below describe general gene information for IGF2BP2. It may not necessarily be applicable to this product.
 NCBI GI #    64085377
 NCBI GeneID    10644
 NCBI Accession #    NP_006539.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_006548.4 [Other Products]
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 UniProt Primary Accession #    Q9Y6M1 [Other Products]
 UniProt Secondary Accession #    A0A4Z0; B3FTN2; B3FTN3; B3FTN4 [Other Products]
 UniProt Related Accession #    Q9Y6M1 [Other Products]
 Molecular Weight    66,121 Da [Similar Products]
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 NCBI Official Full Name    insulin-like growth factor 2 mRNA-binding protein 2 isoform a
 NCBI Official Synonym Full Names    insulin-like growth factor 2 mRNA binding protein 2
 NCBI Official Symbol    IGF2BP2 [Similar Products]
 NCBI Official Synonym Symbols   
p62; IMP2; IMP-2; VICKZ2
[Similar Products]
 NCBI Protein Information    insulin-like growth factor 2 mRNA-binding protein 2; OTTHUMP00000082606; OTTHUMP00000082607; OTTHUMP00000082608; VICKZ family member 2; IGF2 mRNA-binding protein 2; IGF-II mRNA-binding protein 2; hepatocellular carcinoma autoantigen p62
 UniProt Protein Name    Insulin-like growth factor 2 mRNA-binding protein 2
 UniProt Synonym Protein Names   
Hepatocellular carcinoma autoantigen p62; IGF-II mRNA-binding protein 2; VICKZ family member 2
 Protein Family    Insulin-like growth factor 2 mRNA-binding protein
 UniProt Gene Name    IGF2BP2 [Similar Products]
 UniProt Synonym Gene Names    IMP2; VICKZ2 [Similar Products]
 UniProt Entry Name    IF2B2_HUMAN
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 NCBI Summary for IGF2BP2    This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
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 UniProt Comments for IGF2BP2    IGF2BP2: Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. May regulate translation of target mRNAs. Belongs to the RRM IMP/VICKZ family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; Translation

Chromosomal Location of Human Ortholog: 3q27.2

Cellular Component: cytoskeleton; cytoplasm; nucleus; cytosol

Molecular Function: protein binding; mRNA 3'-UTR binding; nucleotide binding; translation regulator activity; mRNA 5'-UTR binding

Biological Process: anatomical structure morphogenesis; mRNA transport; negative regulation of translation; gene expression; regulation of cytokine biosynthetic process

Disease: Diabetes Mellitus, Noninsulin-dependent
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 Research Articles on IGF2BP2    1. non-replications of IGF2BP2 associations with type 2 diabetes
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-IGF2BP2 antibodyDiseases associated with anti-IGF2BP2 antibody
 Products by Pathway  Pathway Diagram
 Binding Of RNA By Insulin-like Growth Factor-2 MRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) Pathway antibodies  Binding Of RNA By Insulin-like Growth Factor-2 MRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 Disease Name  Pubmed Publications
 Diabetes Mellitus Antibodies  >70 publications with IGF2BP2 and Diabetes Mellitus
 Diabetes Mellitus, Type 2 Antibodies  >66 publications with IGF2BP2 and Diabetes Mellitus, Type 2
 Insulin Resistance Antibodies  >16 publications with IGF2BP2 and Insulin Resistance
 Obesity Antibodies  >11 publications with IGF2BP2 and Obesity
 Neoplasms Antibodies  >9 publications with IGF2BP2 and Neoplasms
 Hyperglycemia Antibodies  >9 publications with IGF2BP2 and Hyperglycemia
 Kidney Diseases Antibodies  >4 publications with IGF2BP2 and Kidney Diseases
 Prostatic Neoplasms Antibodies  >2 publications with IGF2BP2 and Prostatic Neoplasms
 Fetal Diseases Antibodies  >2 publications with IGF2BP2 and Fetal Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with IGF2BP2 and Carcinoma, Hepatocellular
Organs/Tissues associated with anti-IGF2BP2 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >23 publications with IGF2BP2 and Blood
 Pancreas Antibodies  >10 publications with IGF2BP2 and Pancreas
 Liver Antibodies  >5 publications with IGF2BP2 and Liver
 Kidney Antibodies  >3 publications with IGF2BP2 and Kidney
 Muscle Antibodies  >2 publications with IGF2BP2 and Muscle
 Ovary Antibodies  >2 publications with IGF2BP2 and Ovary
 Connective Tissue Antibodies  >1 publications with IGF2BP2 and Connective Tissue
 Testis Antibodies  >1 publications with IGF2BP2 and Testis
 Lung Antibodies  >1 publications with IGF2BP2 and Lung
 Prostate Antibodies  >1 publications with IGF2BP2 and Prostate
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