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anti-IGFBP3 antibody :: Goat IGFBP3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421551
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IGFBP3, Polyclonal Antibody

 Also Known As   

Goat anti-IGFBP3 Antibody

 Product Synonym Names    IGFBP3; insulin-like growth factor binding protein 3; tcag7.703; BP-53; IBP3; IGF-binding protein 3; acid stable subunit of the 140 K IGF complex; binding protein 29; binding protein 53; growth hormone-dependent binding protein; IGFBP3 antibody; insulin-like growth factor binding protein 3 antibody; tcag7.703 antibody; BP-53 antibody; IBP3 antibody; IGF-binding protein 3 antibody; acid stable subunit of the 140 K IGF complex antibody; binding protein 29 antibody; binding protein 53 antibody; growth hormone-dependent binding protein antibody
 Product Gene Name   

anti-IGFBP3 antibody

[Similar Products]
 Antibody/Peptide Pairs    IGFBP3 peptide (MBS426446) is used for blocking the activity of IGFBP3 antibody (MBS421551)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    RYKVDYESQS TDTQN
 OMIM    146732
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-RYKVDYESQSTDTQN, from the internal region of the protein sequence according to NP_001013416.1; NP_000589.2.
 Epitope    Internal region
 Note    This antibody is expected to recognise both reported isoforms (NP_001013416.1 and NP_000589.2).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-IGFBP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-IGFBP3 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-IGFBP3 antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
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 Western Blot (WB) of anti-IGFBP3 antibody    (0. 02ug/ml) staining of Human Breast cancer lysate (35ug protein in RIPA buffer) with (B) and without (A) blocking with the immunising peptide. Primary incubation was 1 hour. Detected by chemiluminescence.
anti-IGFBP3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for IGFBP3. It may not necessarily be applicable to this product.
 NCBI GI #    62243248
 NCBI GeneID    3486
 NCBI Accession #    NP_001013416.1 [Other Products]
 NCBI Related Accession #    NP_000589.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001013398.1 [Other Products]
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 UniProt Secondary Accession #    Q2V509; Q6P1M6; Q9UCL4; A4D2F5; D3DVM0 [Other Products]
 UniProt Related Accession #    P17936 [Other Products]
 Molecular Weight    32,223 Da
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 NCBI Official Full Name    insulin-like growth factor-binding protein 3 isoform a
 NCBI Official Synonym Full Names    insulin like growth factor binding protein 3
 NCBI Official Symbol    IGFBP3 [Similar Products]
 NCBI Official Synonym Symbols   
IBP3; BP-53
[Similar Products]
 NCBI Protein Information    insulin-like growth factor-binding protein 3
 UniProt Protein Name    Insulin-like growth factor-binding protein 3
 Protein Family    Insulin-like growth factor-binding protein
 UniProt Gene Name    IGFBP3 [Similar Products]
 UniProt Synonym Gene Names    IBP3; IBP-3; IGF-binding protein 3; IGFBP-3 [Similar Products]
 UniProt Entry Name    IBP3_HUMAN
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 NCBI Summary for IGFBP3    This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IGFBP3    IGFBP3: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.

Protein type: Secreted, signal peptide; Cell development/differentiation; Secreted

Chromosomal Location of Human Ortholog: 7p12.3

Cellular Component: extracellular region; extracellular space; insulin-like growth factor binding protein complex; nucleus

Molecular Function: fibronectin binding; insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding; metal ion binding; protein binding; protein tyrosine phosphatase activator activity

Biological Process: apoptosis; cellular protein metabolic process; negative regulation of cell proliferation; negative regulation of protein amino acid phosphorylation; negative regulation of signal transduction; negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; osteoblast differentiation; positive regulation of apoptosis; positive regulation of catalytic activity; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of MAPKKK cascade; positive regulation of myoblast differentiation; protein amino acid phosphorylation; regulation of apoptosis; regulation of cell growth; regulation of insulin-like growth factor receptor signaling pathway
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 Research Articles on IGFBP3    1. Methylation of IGFBP-3 in colorectal cancer was identified to be significantly associated with risk of recurrence.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IGFBP3 antibodyPathways associated with anti-IGFBP3 antibody
 Reference Product  PubMed Publications
 IGF1 antibody  >282 publications with IGFBP3 and IGF1
 IGF2 antibody  >88 publications with IGFBP3 and IGF2
 IGFALS antibody  >22 publications with IGFBP3 and IGFALS
 TP53 antibody  >14 publications with IGFBP3 and TP53
 MMP2 antibody  >7 publications with IGFBP3 and MMP2
 ADAM12 antibody  >4 publications with IGFBP3 and ADAM12
 MAPK8 antibody  >1 publications with IGFBP3 and MAPK8
 Products by Pathway  Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies  Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
 TP53 Regulates Transcription Of Cell Death Genes Pathway antibodies  TP53 Regulates Transcription Of Cell Death Genes Pathway Diagram
 TP53 Regulates Transcription Of Death Receptors And Ligands Pathway antibodies  TP53 Regulates Transcription Of Death Receptors And Ligands Pathway Diagram
Diseases associated with anti-IGFBP3 antibodyOrgans/Tissues associated with anti-IGFBP3 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >368 publications with IGFBP3 and Breast Neoplasms
 Prostatic Neoplasms Antibodies  >267 publications with IGFBP3 and Prostatic Neoplasms
 Cardiovascular Diseases Antibodies  >249 publications with IGFBP3 and Cardiovascular Diseases
 Liver Diseases Antibodies  >159 publications with IGFBP3 and Liver Diseases
 Colorectal Neoplasms Antibodies  >157 publications with IGFBP3 and Colorectal Neoplasms
 Lung Diseases Antibodies  >149 publications with IGFBP3 and Lung Diseases
 Weight Gain Antibodies  >148 publications with IGFBP3 and Weight Gain
 Inflammation Antibodies  >142 publications with IGFBP3 and Inflammation
 Kidney Diseases Antibodies  >126 publications with IGFBP3 and Kidney Diseases
 Disease Models, Animal Antibodies  >125 publications with IGFBP3 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2955 publications with IGFBP3 and Blood
 Bone Antibodies  >536 publications with IGFBP3 and Bone
 Liver Antibodies  >451 publications with IGFBP3 and Liver
 Prostate Antibodies  >366 publications with IGFBP3 and Prostate
 Muscle Antibodies  >311 publications with IGFBP3 and Muscle
 Vascular Antibodies  >239 publications with IGFBP3 and Vascular
 Connective Tissue Antibodies  >228 publications with IGFBP3 and Connective Tissue
 Brain Antibodies  >221 publications with IGFBP3 and Brain
 Kidney Antibodies  >209 publications with IGFBP3 and Kidney
 Lung Antibodies  >196 publications with IGFBP3 and Lung
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