P01876.2
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UniProt Primary Accession #
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NCBI Official Full Name
Ig alpha-1 chain C region
UniProt Protein Name
Ig alpha-1 chain C region
UniProt Entry Name
IGHA1_HUMAN
UniProt Comments for IGHA1
IGHA1: Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system. A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.
Protein type: Immunoglobulin superfamily
Chromosomal Location of Human Ortholog: 14q32.33
Cellular Component: extracellular space; extracellular region
Molecular Function: antigen binding
Biological Process: receptor-mediated endocytosis; retinal homeostasis; glomerular filtration; antibacterial humoral response; immune response; protein-chromophore linkage
Product References and Citations for anti-IGHA1 antibody
Flanagan J.G., Lefranc M.-P.Cell 36:681-688(1984) Putnam F.W., Liu Y.-S.V.J. Biol. Chem. 254:2865-2874(1979) Hatzivassiliou G., Miller I.Immunity 14:277-289(2001)
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Organs/Tissues associated with anti-IGHA1 antibody
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