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anti-IHH antibody :: Rabbit IHH Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2524188
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IHH, Polyclonal Antibody

 Also Known As   

IHH Polyclonal Antibody

 Product Synonym Names    BDA1; HHG2
 Product Gene Name   

anti-IHH antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    112500
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    1.4mg/mL (lot specific)
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 Immunogen    Recombinant protein of human IHH
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-IHH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-IHH antibody

   This gene encodes a member of the hedgehog family of secreted signaling molecules. Hedgehog proteins are essential regulators of a variety of developmental processes including growth, patterning and morphogenesis. The encoded protein specifically plays a role in bone growth an differentiation. Mutations in this gene are the cause of brachydactyly type A1 which is characterized by shortening or malformation of the phalanges. Mutations in this gene are also the cause of acrocapitofemoral dysplasia.
 Applications Tested/Suitable for anti-IHH antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-IHH antibody    IHC: 1:50-1:200
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 Immunohistochemistry (IHC) of anti-IHH antibody    Immunohistochemistry of Human lung cancer using IHH Polyclonal Antibody at dilution of 1:30
anti-IHH antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-IHH antibody    Immunohistochemistry of Human lung cancer using IHH Polyclonal Antibody at dilution of 1:30
anti-IHH antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for IHH. It may not necessarily be applicable to this product.
 NCBI GI #    33112634
 NCBI GeneID    3549
 NCBI Accession #    Q14623.4 [Other Products]
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 UniProt Secondary Accession #    O43322; Q8N4B9; B9EGM5 [Other Products]
 UniProt Related Accession #    Q14623 [Other Products]
 Molecular Weight    45,251 Da
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 NCBI Official Full Name    Indian hedgehog protein
 NCBI Official Synonym Full Names    indian hedgehog
 NCBI Official Symbol    IHH [Similar Products]
 NCBI Official Synonym Symbols   
BDA1; HHG2
[Similar Products]
 NCBI Protein Information    indian hedgehog protein; HHG-2; Indian hedgehog homolog
 UniProt Protein Name    Indian hedgehog protein
 UniProt Synonym Protein Names   
HHG-2Cleaved into the following 2 chains:Indian hedgehog protein N-product; Indian hedgehog protein C-product
 Protein Family    Indian hedgehog protein
 UniProt Gene Name    IHH [Similar Products]
 UniProt Synonym Gene Names    IHH [Similar Products]
 UniProt Entry Name    IHH_HUMAN
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 NCBI Summary for IHH    This gene encodes a member of the hedgehog family of secreted signaling molecules. Hedgehog proteins are essential regulators of a variety of developmental processes including growth, patterning and morphogenesis. The encoded protein specifically plays a role in bone growth an differentiation. Mutations in this gene are the cause of brachydactyly type A1 which is characterized by shortening or malformation of the phalanges. Mutations in this gene are also the cause of acrocapitofemoral dysplasia. [provided by RefSeq, Feb 2010]
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 UniProt Comments for IHH    IHH: Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP). Expressed in embryonic lung, and in adult kidney and liver. Belongs to the hedgehog family.

Chromosomal Location of Human Ortholog: 2q33-q35

Cellular Component: extracellular matrix; extracellular space; plasma membrane

Molecular Function: peptidase activity; patched binding; calcium ion binding

Biological Process: vitelline membrane formation; proteoglycan metabolic process; maternal process involved in pregnancy; cell maturation; positive regulation of collagen biosynthetic process; cell fate specification; proteolysis; embryonic pattern specification; response to estradiol stimulus; positive regulation of T cell differentiation in the thymus; smooth muscle development; cell-cell signaling; embryonic digestive tract morphogenesis; regulation of growth; pancreas development; positive regulation of mesenchymal cell proliferation; positive regulation of smoothened signaling pathway; heart looping; skeletal development; bone resorption; negative regulation of immature T cell proliferation in the thymus; smoothened signaling pathway; intein-mediated protein splicing; in utero embryonic development; multicellular organism growth; negative regulation of eye pigmentation; negative regulation of T cell differentiation in the thymus; negative regulation of signal transduction; patterning of blood vessels; osteoblast differentiation; positive regulation of chondrocyte differentiation; cartilage development; neuron development; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; embryonic camera-type eye morphogenesis; positive regulation of alpha-beta T cell differentiation; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; negative regulation of alpha-beta T cell differentiation

Disease: Brachydactyly, Type A1; Acrocapitofemoral Dysplasia
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 Research Articles on IHH    1. Increased Ihh is associated with the severity of osteoarthritis cartilage damage. Elevated Ihh content in human knee joint synovial fluid correlates with early cartilage lesions.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IHH antibodyPathways associated with anti-IHH antibody
 Reference Product  PubMed Publications
 RUNX2 antibody  >71 publications with IHH and RUNX2
 PTCH1 antibody  >43 publications with IHH and PTCH1
 BMP2 antibody  >25 publications with IHH and BMP2
 PTHLH antibody  >21 publications with IHH and PTHLH
 HHIP antibody  >17 publications with IHH and HHIP
 TGFB2 antibody  >7 publications with IHH and TGFB2
 PTCH2 antibody  >7 publications with IHH and PTCH2
 MSX2 antibody  >6 publications with IHH and MSX2
 BOC antibody  >3 publications with IHH and BOC
 CDON antibody  >2 publications with IHH and CDON
 Products by Pathway  Pathway Diagram
 Activation Of SMO Pathway antibodies  Activation Of SMO Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Hedgehog 'on' State Pathway antibodies  Hedgehog 'on' State Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Ligand Biogenesis Pathway antibodies  Hedgehog Ligand Biogenesis Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
Diseases associated with anti-IHH antibodyOrgans/Tissues associated with anti-IHH antibody
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >127 publications with IHH and Congenital Abnormalities
 Hypertrophy Antibodies  >96 publications with IHH and Hypertrophy
 Brain Diseases Antibodies  >21 publications with IHH and Brain Diseases
 Cardiovascular Diseases Antibodies  >20 publications with IHH and Cardiovascular Diseases
 Liver Diseases Antibodies  >20 publications with IHH and Liver Diseases
 Brachydactyly type A1 Antibodies  >17 publications with IHH and Brachydactyly type A1
 Fibrosis Antibodies  >13 publications with IHH and Fibrosis
 Hypertension Antibodies  >12 publications with IHH and Hypertension
 Hyperplasia Antibodies  >11 publications with IHH and Hyperplasia
 Cell Transformation, Neoplastic Antibodies  >10 publications with IHH and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >133 publications with IHH and Embryonic Tissue
 Intestine Antibodies  >28 publications with IHH and Intestine
 Kidney Antibodies  >24 publications with IHH and Kidney
 Uterus Antibodies  >23 publications with IHH and Uterus
 Eye Antibodies  >14 publications with IHH and Eye
 Prostate Antibodies  >14 publications with IHH and Prostate
 Uncharacterized Tissue Antibodies  >4 publications with IHH and Uncharacterized Tissue
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