AAC64258.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
IkappaB kinase complex associated protein
NCBI Official Synonym Full Names
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
NCBI Official Synonym Symbols
FD; DYS; ELP1; IKAP; IKI3; TOT1 [Similar Products]
NCBI Protein Information
elongator complex protein 1; p150; IKK complex-associated protein; ikappaB kinase complex-associated protein; elongator acetyltransferase complex subunit 1
UniProt Protein Name
Elongator complex protein 1
UniProt Synonym Protein Names
IkappaB kinase complex-associated protein; IKK complex-associated protein; p150
UniProt Synonym Gene Names
UniProt Entry Name
ELP1_HUMAN
NCBI Summary for IKBKAP
The protein encoded by this gene is a scaffold protein and a regulator for 3 different kinases involved in proinflammatory signaling. This encoded protein can bind NF-kappa-B-inducing kinase (NIK) and IKKs through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. [provided by RefSeq, Jul 2008]
UniProt Comments for IKBKAP
IKBKAP: May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK). Interacts preferentially with MAP3K14/NIK followed by IKK-alpha and IKK-beta. Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, and two yet unidentified proteins, p30 and p38. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with ELP3. Belongs to the ELP1/IKA1 family.
Protein type: Transcription regulation; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 9q31
Cellular Component: transcription elongation factor complex; Elongator holoenzyme complex; cytoplasm; nucleolus; histone acetyltransferase complex
Molecular Function: signal transducer activity; protein binding; phosphorylase kinase regulator activity
Biological Process: regulation of transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; RNA elongation from RNA polymerase II promoter; immune response; protein complex assembly; signal transduction; regulation of protein kinase activity; protein amino acid phosphorylation; positive regulation of cell migration
Disease: Neuropathy, Hereditary Sensory And Autonomic, Type Iii
Research Articles on IKBKAP
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Products associated with anti-IKBKAP antibody
Pathways associated with anti-IKBKAP antibody
Diseases associated with anti-IKBKAP antibody
Organs/Tissues associated with anti-IKBKAP antibody
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