Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow IKBKE rightarrow Polyclonal IKBKE  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • ApoMark Apoptosis Kit IHC Kit
 • Platelet Derived Growth Factor AB (PDGF-AB) ELISA Kit
 • B2 bradykinin receptor (Bdkrb2) Recombinant Protein
 • Vascular Endothelial Growth Factor D (VEGF-D) ELISA Kit
 • Flag-Tag Antibody
 • 39S ribosomal protein L19, mitochondrial (MRPL19) ELISA Kit
 • PEK-PERK Antibody
 • 1-acyl-sn-glycerol-3-phosph ate acyltransferase epsilon (AGPA... ELISA Kit
 • transthyretin (TTR) Antibody
 • Selenoprotein P (SEPP1) Recombinant Protein
 • OxiSelect Total Glutathione (GSSG-GSH) Assay Kit
 • 14-3-3 sigma Recombinant Protein
 • 40S ribosomal protein S12 (RPS12) Antibody
 • Adenovirus (ADV) antibody (IgG) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-IKBKE antibody :: Rabbit anti-Human IKK epsilon (IKKE) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9212797
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IKK epsilon (IKKE) (IKBKE), Polyclonal Antibody

 Also Known As   

IKK epsilon (IKKE) Antibody (C-term)

 Product Synonym Names    Inhibitor of nuclear factor kappa-B kinase subunit epsilon; I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IkBKE; Inducible I kappa-B kinase; IKK-i; IKBKE; IKKE; IKKI; KIAA0151
 Product Gene Name   

anti-IKBKE antibody

[Similar Products]
 Antibody/Peptide Pairs    IKK epsilon (IKKE) peptide (MBS9227571) is used for blocking the activity of IKK epsilon (IKKE) antibody (MBS9212797)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Immunogen Sequence Positions    686-716
 OMIM    605048
 3D Structure    ModBase 3D Structure for Q14164
Section Bar
 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human
Section Bar
 Specificity    This IKK epsilon (IKKE) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 686-716 amino acids from the C-terminal region of human IKK epsilon (IKKE).
 Purity/Purification    Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    Vial Concentration: 0.5 (lot specific)
Section Bar
 Antigen Type    Synthetic Peptide
 Antigen Source    HUMAN
Section Bar
 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-IKBKE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-IKBKE antibody

   Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).
 Product Categories/Family for anti-IKBKE antibody    Cancer; Cell Biology; Immunology; Signal Transduction
 Applications Tested/Suitable for anti-IKBKE antibody   

Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-IKBKE antibody    WB~~1:1000
Section Bar
 Western Blot (WB) of anti-IKBKE antibody    The anti-IKKE Pab is used in Western blot to detect IKKE in 293 cell lysate.
anti-IKBKE antibody Western Blot (WB) (WB) image
Section Bar
 Immunohistochemistry (IHC) of anti-IKBKE antibody    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
anti-IKBKE antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunohistochemistry (IHC) of anti-IKBKE antibody    Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with IKKE Antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
anti-IKBKE antibody Immunohistochemistry (IHC) (IHC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for IKBKE. It may not necessarily be applicable to this product.
 NCBI GI #    300863151
 NCBI GeneID    9641
 NCBI Accession #    NP_001180250.1 [Other Products]
 NCBI Related Accession #    NP_001180251.1; NP_054721.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001193321.1 [Other Products]
Section Bar
 UniProt Primary Accession #    Q14164 [Other Products]
 UniProt Secondary Accession #    Q3B754; Q3KR43; Q5JTS6; D3DT78 [Other Products]
 UniProt Related Accession #    Q14164 [Other Products]
 Molecular Weight    80462
Table BarTOPTable Bar
 NCBI Official Full Name    inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 3
 NCBI Official Synonym Full Names    inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
 NCBI Official Symbol    IKBKE [Similar Products]
 NCBI Official Synonym Symbols   
IKKE; IKKI; IKK-E; IKK-i
[Similar Products]
 NCBI Protein Information    inhibitor of nuclear factor kappa-B kinase subunit epsilon
 UniProt Protein Name    Inhibitor of nuclear factor kappa-B kinase subunit epsilon
 UniProt Synonym Protein Names   
Inducible I kappa-B kinase; IKK-i
 Protein Family    Inhibitor of nuclear factor kappa-B kinase
 UniProt Gene Name    IKBKE [Similar Products]
 UniProt Synonym Gene Names    IKKE; IKKI; KIAA0151; I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IkBKE; IKK-i [Similar Products]
 UniProt Entry Name    IKKE_HUMAN
Section Bar
 NCBI Summary for IKBKE    IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]
Section Bar
 UniProt Comments for IKBKE    IKKE: a oncogenic kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Plays a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response. Its redistribution to PML nuclear bodies upon DNA damage is TOPORS-dependent. Is a breast cancer oncogene that exerts its oncogenic properties through cRel.

Protein type: Inhibitor; Kinase, protein; EC 2.7.11.10; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Other group; IKK family

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: nucleoplasm; PML body; cytoplasm; mitochondrial membrane; endosome membrane; cytosol; nucleus

Molecular Function: NF-kappaB-inducing kinase activity; protein binding; IkappaB kinase activity; ATP binding

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; DNA damage response, signal transduction resulting in induction of apoptosis; MyD88-independent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; immune response; toll-like receptor 3 signaling pathway; I-kappaB phosphorylation; toll-like receptor 4 signaling pathway; negative regulation of interferon type I production; protein amino acid phosphorylation
Table BarTOPTable Bar
 

Product References and Citations for anti-IKBKE antibody

   Blume-Jensen P, et al. Nature 2001. 411: 355.
Cantrell D, J. Cell Sci. 2001. 114: 1439.
Jhiang S Oncogene 2000. 19: 5590.
Manning G, et al. Science 2002. 298: 1912.
Moller, D, et al. Am. J. Physiol. 1994. 266: C351-C359.
Robertson, S. et al. Trends Genet. 2000. 16: 368.
Robinson D, et al. Oncogene 2000. 19: 5548.
Van der Ven, P, et al. Hum. Molec. Genet. 1993. 2: 1889.
Vanhaesebroeck, B, et al. Biochem. J. 2000. 346: 561.
Van Weering D, et al. Recent Results Cancer Res. 1998. 154: 271.
Section Bar
 Research Articles on IKBKE    1. A role for APPL1 in TLR3/4-dependent TBK1 and IKKepsilon activation in macrophages.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Pathways associated with anti-IKBKE antibodyDiseases associated with anti-IKBKE antibody
 Products by Pathway  Pathway Diagram
 Oxidative Phosphorylation Pathway antibodies  Oxidative Phosphorylation Pathway Diagram
 Oxidative Phosphorylation Pathway antibodies  Oxidative Phosphorylation Pathway Diagram
 Oxidative Phosphorylation Pathway antibodies  Oxidative Phosphorylation Pathway Diagram
 Oxidative Phosphorylation Pathway antibodies  Oxidative Phosphorylation Pathway Diagram
 Oxidative Phosphorylation Pathway antibodies  Oxidative Phosphorylation Pathway Diagram
 Oxidative Phosphorylation Pathway antibodies  Oxidative Phosphorylation Pathway Diagram
 Oxidative Phosphorylation Pathway antibodies  Oxidative Phosphorylation Pathway Diagram
 Oxidative Phosphorylation Pathway antibodies  Oxidative Phosphorylation Pathway Diagram
 Oxidative Phosphorylation Pathway antibodies  Oxidative Phosphorylation Pathway Diagram
 Oxidative Phosphorylation Pathway antibodies  Oxidative Phosphorylation Pathway Diagram
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >438 publications with IKBKE and Necrosis
 Inflammation Antibodies  >190 publications with IKBKE and Inflammation
 Cell Transformation, Neoplastic Antibodies  >28 publications with IKBKE and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >26 publications with IKBKE and Disease Models, Animal
 Lymphoma, Non-Hodgkin Antibodies  >17 publications with IKBKE and Lymphoma, Non-Hodgkin
 Atherosclerosis Antibodies  >16 publications with IKBKE and Atherosclerosis
 Adenocarcinoma Antibodies  >13 publications with IKBKE and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >13 publications with IKBKE and Neoplasms, Experimental
 Liver Diseases Antibodies  >13 publications with IKBKE and Liver Diseases
 Nervous System Diseases Antibodies  >12 publications with IKBKE and Nervous System Diseases
Organs/Tissues associated with anti-IKBKE antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >181 publications with IKBKE and Blood
 Vascular Antibodies  >59 publications with IKBKE and Vascular
 Lung Antibodies  >56 publications with IKBKE and Lung
 Skin Antibodies  >46 publications with IKBKE and Skin
 Embryonic Tissue Antibodies  >33 publications with IKBKE and Embryonic Tissue
 Bone Antibodies  >32 publications with IKBKE and Bone
 Kidney Antibodies  >30 publications with IKBKE and Kidney
 Muscle Antibodies  >27 publications with IKBKE and Muscle
 Intestine Antibodies  >21 publications with IKBKE and Intestine
 Heart Antibodies  >21 publications with IKBKE and Heart
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions