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anti-IKBKE antibody :: Rabbit anti-Human IKK epsilon Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS625447 anti-IKBKE antibody
Unit / Price
0.1 mg  /  $740 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IKK epsilon (IKBKE), Polyclonal Antibody

 Also Known As   

IKK epsilon, phosphorylated (Thr501) (IKKe)

 Product Synonym Names    Anti -IKK epsilon, phosphorylated (Thr501) (IKKe)
 Product Gene Name   

anti-IKBKE antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (206643586..206670223). Location: 1q32.1
 OMIM    605048
 3D Structure    ModBase 3D Structure for Q14164
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes human IKKe pT501, phosphorylated, Mr 85kD. Shows minimal reactivity by Western Blot with non-phosphorylated IKKe.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide, before the addition of glycerol to 40%. No stabilizing proteins added.
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 Immunogen    Synthetic phoshopeptide sequence (RSRLRpTLAEVL) corresponding to aa496-506 of human IKKe (KLH coupled)
 Positive Control    HeLa cells or TNF inducible KBM-5 cells
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-IKBKE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-IKBKE antibody

   Nuclear Factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during the activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kB is associated with IkB proteins in the cytoplasm of the cell, which inhibit NF- B activity. IkB proteins are phosphorylated by an I B kinase complex consisting of at least three proteins, IKKa, IKKb and
 Product Categories/Family for anti-IKBKE antibody    Antibodies; Abs to Protein Kinases
 Applications Tested/Suitable for anti-IKBKE antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-IKBKE antibody    Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:2500-1:5000
Western Blot: 1:500
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NCBI/Uniprot data below describe general gene information for IKBKE. It may not necessarily be applicable to this product.
 NCBI GI #    300937401
 NCBI GeneID    9641
 NCBI Accession #    NP_001180251.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001193322.1 [Other Products]
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 UniProt Primary Accession #    Q14164 [Other Products]
 UniProt Secondary Accession #    Q3B754; Q3KR43; Q5JTS6; D3DT78 [Other Products]
 UniProt Related Accession #    Q14164 [Other Products]
 Molecular Weight    80,462 Da [Similar Products]
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 NCBI Official Full Name    inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 2
 NCBI Official Synonym Full Names    inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
 NCBI Official Symbol    IKBKE [Similar Products]
 NCBI Official Synonym Symbols   
IKKE; IKKI; IKK-E; IKK-i
[Similar Products]
 NCBI Protein Information    inhibitor of nuclear factor kappa-B kinase subunit epsilon; IKK-epsilon; I-kappa-B kinase epsilon; inducible IkappaB kinase; IKK-related kinase epsilon; inducible I kappa-B kinase
 UniProt Protein Name    Inhibitor of nuclear factor kappa-B kinase subunit epsilon
 UniProt Synonym Protein Names   
Inducible I kappa-B kinase
 Protein Family    Inhibitor of nuclear factor kappa-B kinase
 UniProt Gene Name    IKBKE [Similar Products]
 UniProt Synonym Gene Names    IKKE; IKKI; KIAA0151; I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IkBKE; IKK-i [Similar Products]
 UniProt Entry Name    IKKE_HUMAN
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 NCBI Summary for IKBKE    IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]
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 UniProt Comments for IKBKE    IKKE: a oncogenic kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Plays a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response. Its redistribution to PML nuclear bodies upon DNA damage is TOPORS-dependent. Is a breast cancer oncogene that exerts its oncogenic properties through cRel.

Protein type: Protein kinase, Other; EC 2.7.11.10; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Inhibitor; Other group; IKK family

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: nucleoplasm; PML body; mitochondrial membrane; cytoplasm; endosome membrane; cytosol; nucleus

Molecular Function: NF-kappaB-inducing kinase activity; protein binding; IkappaB kinase activity; ATP binding

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; DNA damage response, signal transduction resulting in induction of apoptosis; MyD88-independent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; immune response; toll-like receptor 3 signaling pathway; I-kappaB phosphorylation; negative regulation of interferon type I production; protein amino acid phosphorylation; toll-like receptor 4 signaling pathway
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 Research Articles on IKBKE    1. DDX3 is a scaffolding adaptor that directly facilitates phosphorylation of IRF3 by IKK-epsilon.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IKBKE antibodyPathways associated with anti-IKBKE antibody
 Reference Product  PubMed Publications
 TBK1 antibody  >32 publications with IKBKE and TBK1
 IRF3 antibody  >28 publications with IKBKE and IRF3
 TANK antibody  >21 publications with IKBKE and TANK
 TNFAIP3 antibody  >11 publications with IKBKE and TNFAIP3
 IRF7 antibody  >6 publications with IKBKE and IRF7
 UBC antibody  >4 publications with IKBKE and UBC
 TAX1BP1 antibody  >3 publications with IKBKE and TAX1BP1
 AZI2 antibody  >2 publications with IKBKE and AZI2
 MAVS antibody  >1 publications with IKBKE and MAVS
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies  Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with anti-IKBKE antibodyOrgans/Tissues associated with anti-IKBKE antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >437 publications with IKBKE and Necrosis
 Inflammation Antibodies  >187 publications with IKBKE and Inflammation
 Neoplasms Antibodies  >173 publications with IKBKE and Neoplasms
 Carcinoma Antibodies  >48 publications with IKBKE and Carcinoma
 Congenital Abnormalities Antibodies  >39 publications with IKBKE and Congenital Abnormalities
 Disease Models, Animal Antibodies  >26 publications with IKBKE and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >20 publications with IKBKE and Cardiovascular Diseases
 Prostatic Diseases Antibodies  >14 publications with IKBKE and Prostatic Diseases
 Atherosclerosis Antibodies  >14 publications with IKBKE and Atherosclerosis
 Adenocarcinoma Antibodies  >13 publications with IKBKE and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >176 publications with IKBKE and Blood
 Vascular Antibodies  >58 publications with IKBKE and Vascular
 Lung Antibodies  >55 publications with IKBKE and Lung
 Skin Antibodies  >46 publications with IKBKE and Skin
 Bone Antibodies  >32 publications with IKBKE and Bone
 Embryonic Tissue Antibodies  >32 publications with IKBKE and Embryonic Tissue
 Kidney Antibodies  >30 publications with IKBKE and Kidney
 Muscle Antibodies  >27 publications with IKBKE and Muscle
 Intestine Antibodies  >21 publications with IKBKE and Intestine
 Bone Marrow Antibodies  >19 publications with IKBKE and Bone Marrow
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