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anti-IKBKG antibody :: Rabbit IKK gamma Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150068
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IKK gamma (IKBKG), Polyclonal Antibody

 Also Known As   

IKK gamma Antibody

 Product Synonym Names    IKK gamma; IP; IP1; IP2; FIP3; IPD2; NEMO; FIP-3; Fip3p; AMCBX1; ZC2HC9; IKK-gamma; NF-kappa-B essential modulator; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
 Product Gene Name   

anti-IKBKG antibody

[Similar Products]
 Antibody/Peptide Pairs    IKK gamma peptide (MBS153106) is used for blocking the activity of IKK gamma antibody (MBS150068)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 308300
 3D Structure    ModBase 3D Structure for Q9Y6K9
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    IKK gamma has no cross response to IKK alpha or IKK beta.
 Purity/Purification    IKK gamma Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
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 Conjugate    Unconjugated
 Immunogen    IKK gamma antibody was raised against a 17 amino acid peptide near the carboxy terminus of human IKK gamma.
 Buffer    IKK gamma Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    IKK gamma antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-IKBKG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IKBKG antibody

   IKK gamma Antibody: Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κB is associated with IκB proteins in the cell cytoplasm, which inhibit NF-κB activity. The IκB kinase (IKKα and IKKβ) phosphorylates IkB and mediates NF-κB activation. A novel molecule in the IKK complex was recently identified and termed IKKγ/NEMO/FIP3/IKKAP1. IKKγ interacts with IKKβ and is required for the activation of IKK complex and NF-κB by LPS, PMA, TNF, and IL-1 stimulation. FIP3 was also shown to bind to RIP and NIK and to mediate TNF-induced NF-κB activation.
 Applications Tested/Suitable for anti-IKBKG antibody   

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)

 Application Notes for anti-IKBKG antibody    IKK gamma antibody can be used for detection of IKK gamma by Western blot at 1 mug/mL. A 52 kDa band should be detected. Antibody can also be used for immunocytochemistry starting at 5 mug/mL.
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 Western Blot (WB) of anti-IKBKG antibody    Western blot analysis of IKK gamma in HeLa whole cell lysate with IKK gamma antibody at 1 μg/mL.
anti-IKBKG antibody Western Blot (WB) (WB) image
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 Immunocytochemistry (ICC) of anti-IKBKG antibody    Immunocytochemistry of IKK gamma in HeLa cells with IKK gamma antibody at 5 μg/mL.
anti-IKBKG antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for IKBKG. It may not necessarily be applicable to this product.
 NCBI GI #    3641279
 NCBI GeneID    8517
 NCBI Accession #    AF074382 [Other Products]
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 UniProt Primary Accession #    Q9Y6K9 [Other Products]
 UniProt Secondary Accession #    Q7LBY6; Q7Z7F1 [Other Products]
 UniProt Related Accession #    Q9Y6K9 [Other Products]
 Molecular Weight    52 kDa
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 NCBI Official Full Name    Homo sapiens IkB kinase gamma subunit (IKK-gamma) mRNA, complete cds
 NCBI Official Synonym Full Names    inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
 NCBI Official Symbol    IKBKG [Similar Products]
 NCBI Official Synonym Symbols   
IP; IP1; IP2; FIP3; IPD2; NEMO; FIP-3; Fip3p; IMD33; AMCBX1; ZC2HC9; IKK-gamma
[Similar Products]
 NCBI Protein Information    NF-kappa-B essential modulator; IKKG; IKKAP1; incontinentia pigmenti; IkB kinase gamma subunit; ikB kinase subunit gamma; NFkappaB essential modulator; NF-kappa-B essential modifier; I-kappa-B kinase subunit gamma; ikB kinase-associated protein 1; inhibitor of nuclear factor kappa-B kinase subunit gamma
 UniProt Protein Name    NF-kappa-B essential modulator
 UniProt Synonym Protein Names   
FIP-3; IkB kinase-associated protein 1; IKKAP1; Inhibitor of nuclear factor kappa-B kinase subunit gamma; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma; NF-kappa-B essential modifier
 UniProt Gene Name    IKBKG [Similar Products]
 UniProt Synonym Gene Names    FIP3; NEMO; NEMO; IKKAP1; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma [Similar Products]
 UniProt Entry Name    NEMO_HUMAN
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 NCBI Summary for IKBKG    This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Aug 2011]
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 UniProt Comments for IKBKG    IKKG: a regulatory subunit of the IKK-signalosome complex. Interacts preferentially with IKK-beta but also able to interact with IKK-alpha, IKAP, TAX, RIP and MAP3K14/NIK. Defects are the cause of familial incontinentia pigmenti type II (IP2).

Protein type: Adaptor/scaffold; Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: spindle pole; cytoplasm; IkappaB kinase complex; intracellular; nucleus; cytosol; ubiquitin ligase complex

Molecular Function: protein domain specific binding; peroxisome proliferator activated receptor binding; protein binding; signal transducer activity; protein homodimerization activity; protein heterodimerization activity; ubiquitin protein ligase binding; metal ion binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; establishment of vesicle localization; viral reproduction; activation of MAPK activity; apoptosis; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; B cell homeostasis; positive regulation of interferon type I production; JNK cascade; inflammatory response; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; response to virus; MyD88-independent toll-like receptor signaling pathway; activation of NF-kappaB-inducing kinase; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; response to DNA damage stimulus

Disease: Invasive Pneumococcal Disease, Recurrent Isolated, 2; Ectodermal Dysplasia, Hypohidrotic, With Immune Deficiency; Immunodeficiency Without Anhidrotic Ectodermal Dysplasia; Immunodeficiency 33; Incontinentia Pigmenti; Ectodermal Dysplasia, Anhidrotic, With Immunodeficiency, Osteopetrosis, And Lymphedema
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 Research Articles on IKBKG    1. NEMO patients without ectodermal dysplasia and anhidrosis have more robust immunologic responses.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IKBKG antibodyPathways associated with anti-IKBKG antibody
 Reference Product  PubMed Publications
 IKBKB antibody  >297 publications with IKBKG and IKBKB
 TRAF6 antibody  >16 publications with IKBKG and TRAF6
 CHUK antibody  >15 publications with IKBKG and CHUK
 BCL10 antibody  >7 publications with IKBKG and BCL10
 CYLD antibody  >6 publications with IKBKG and CYLD
 RIPK1 antibody  >5 publications with IKBKG and RIPK1
 MALT1 antibody  >4 publications with IKBKG and MALT1
 UBC antibody  >1 publications with IKBKG and UBC
 NFKBIA antibody  >1 publications with IKBKG and NFKBIA
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of NF-kappaB In B Cells Pathway antibodies  Activation Of NF-kappaB In B Cells Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
Diseases associated with anti-IKBKG antibodyOrgans/Tissues associated with anti-IKBKG antibody
 Disease Name  Pubmed Publications
 Incontinentia Pigmenti Antibodies  >81 publications with IKBKG and Incontinentia Pigmenti
 Necrosis Antibodies  >66 publications with IKBKG and Necrosis
 Inflammation Antibodies  >40 publications with IKBKG and Inflammation
 Nervous System Diseases Antibodies  >20 publications with IKBKG and Nervous System Diseases
 Adenocarcinoma Antibodies  >6 publications with IKBKG and Adenocarcinoma
 Disease Models, Animal Antibodies  >6 publications with IKBKG and Disease Models, Animal
 Liver Diseases Antibodies  >6 publications with IKBKG and Liver Diseases
 Liver Neoplasms Antibodies  >5 publications with IKBKG and Liver Neoplasms
 Breast Neoplasms Antibodies  >5 publications with IKBKG and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >4 publications with IKBKG and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >50 publications with IKBKG and Blood
 Skin Antibodies  >50 publications with IKBKG and Skin
 Brain Antibodies  >15 publications with IKBKG and Brain
 Bone Antibodies  >11 publications with IKBKG and Bone
 Liver Antibodies  >8 publications with IKBKG and Liver
 Eye Antibodies  >7 publications with IKBKG and Eye
 Kidney Antibodies  >7 publications with IKBKG and Kidney
 Embryonic Tissue Antibodies  >3 publications with IKBKG and Embryonic Tissue
 Lung Antibodies  >3 publications with IKBKG and Lung
 Muscle Antibodies  >3 publications with IKBKG and Muscle
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