NP_001093326.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,953 Da
NCBI Official Full Name
NF-kappa-B essential modulator isoform b
NCBI Official Synonym Full Names
inhibitor of nuclear factor kappa B kinase subunit gamma
NCBI Official Synonym Symbols
IP; IP1; IP2; FIP3; IKKG; IPD2; NEMO; FIP-3; Fip3p; IMD33; AMCBX1; IKKAP1; ZC2HC9; IKK-gamma [Similar Products]
NCBI Protein Information
NF-kappa-B essential modulator
UniProt Protein Name
NF-kappa-B essential modulator
UniProt Synonym Protein Names
FIP-3; IkB kinase-associated protein 1; IKKAP1; Inhibitor of nuclear factor kappa-B kinase subunit gamma; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma; NF-kappa-B essential modifier
UniProt Synonym Gene Names
FIP3; NEMO; NEMO; IKKAP1; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma [Similar Products]
NCBI Summary for IKK gamma
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Mar 2016]
UniProt Comments for IKK gamma
Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.
Research Articles on IKK gamma
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Disclaimer
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Products associated with anti-IKK gamma antibody
Pathways associated with anti-IKK gamma antibody
Diseases associated with anti-IKK gamma antibody
Disease Name |
Pubmed Publications |
Incontinentia Pigmenti Antibodies |
>60 publications with IKK gamma and Incontinentia Pigmenti |
Necrosis Antibodies |
>54 publications with IKK gamma and Necrosis |
Inflammation Antibodies |
>32 publications with IKK gamma and Inflammation |
Neoplasms Antibodies |
>25 publications with IKK gamma and Neoplasms |
Carcinoma Antibodies |
>7 publications with IKK gamma and Carcinoma |
Breast Neoplasms Antibodies |
>4 publications with IKK gamma and Breast Neoplasms |
Liver Diseases Antibodies |
>4 publications with IKK gamma and Liver Diseases |
Liver Neoplasms Antibodies |
>3 publications with IKK gamma and Liver Neoplasms |
Neoplasms, Experimental Antibodies |
>3 publications with IKK gamma and Neoplasms, Experimental |
Ectodermal Dysplasia, Anhidrotic, with Immunodeficiency, Osteopetrosis, and Lymphedema Antibodies |
>2 publications with IKK gamma and Ectodermal Dysplasia, Anhidrotic, with Immunodeficiency, Osteopetrosis, and Lymphedema |
Organs/Tissues associated with anti-IKK gamma antibody
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