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anti-IL12A antibody :: Rabbit IL-12A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8222538
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL-12A (IL12A), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-IL-12A Antibody

 Product Synonym Names    NKSF1; Interleukin-12 subunit alpha; IL-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL-12 subunit p35; NK cell stimulatory factor chain 1; NKSF1
 Product Gene Name   

anti-IL12A antibody

[Similar Products]
 Antibody/Peptide Pairs    IL-12A peptide (MBS8217269) is used for blocking the activity of IL-12A antibody (MBS8222538)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    161560
 3D Structure    ModBase 3D Structure for P29459
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Bovine, Dog, Porcine, Sheep
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 Specificity    Recognizes endogenous levels of IL-12A protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the center region of human IL-12A. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-IL12A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IL12A antibody

   Rabbit polyclonal antibody to IL-12A
 Applications Tested/Suitable for anti-IL12A antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-IL12A antibody    WB (1/500 - 1/1000), IHC (1/100 - 1/200)
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 Western Blot (WB) of anti-IL12A antibody    Western blot analysis of IL-12A expression in MDA-MB231 (A) whole cell lysates.
anti-IL12A antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-IL12A antibody    Immunohistochemical analysis of IL-12A staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-IL12A antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for IL12A. It may not necessarily be applicable to this product.
 NCBI GI #    24430219
 NCBI GeneID    3592
 NCBI Accession #    NP_000873.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000882.3 [Other Products]
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 UniProt Primary Accession #    P29459 [Other Products]
 UniProt Secondary Accession #    Q96QZ1 [Other Products]
 UniProt Related Accession #    P29459 [Other Products]
 Molecular Weight    24,874 Da
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 NCBI Official Full Name    interleukin-12 subunit alpha
 NCBI Official Synonym Full Names    interleukin 12A
 NCBI Official Symbol    IL12A [Similar Products]
 NCBI Official Synonym Symbols   
P35; CLMF; NFSK; NKSF1; IL-12A
[Similar Products]
 NCBI Protein Information    interleukin-12 subunit alpha
 UniProt Protein Name    Interleukin-12 subunit alpha
 UniProt Synonym Protein Names   
Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL-12 subunit p35; NK cell stimulatory factor chain 1; NKSF1
 Protein Family    Interleukin
 UniProt Gene Name    IL12A [Similar Products]
 UniProt Synonym Gene Names    NKSF1; IL-12A; CLMF p35; NKSF1 [Similar Products]
 UniProt Entry Name    IL12A_HUMAN
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 NCBI Summary for IL12A    This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IL12A    IL12A: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine- activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-6 superfamily.

Protein type: Secreted; Cytokine; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q25.33

Cellular Component: extracellular space; interleukin-12 complex; cytoplasm

Molecular Function: protein binding; interleukin-27 binding; growth factor activity; interleukin-12 beta subunit binding; protein heterodimerization activity; cytokine activity; interleukin-12 receptor binding

Biological Process: cell migration; positive regulation of NK T cell activation; positive regulation of cell adhesion; negative regulation of smooth muscle cell proliferation; positive regulation of T cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; response to virus; positive regulation of tyrosine phosphorylation of Stat4 protein; response to lipopolysaccharide; positive regulation of natural killer cell mediated cytotoxicity; defense response to protozoan; positive regulation of natural killer cell activation; response to UV-B; defense response to Gram-positive bacterium; positive regulation of interferon-gamma production; negative regulation of interleukin-17 production; positive regulation of mononuclear cell proliferation; positive regulation of T cell differentiation; positive regulation of lymphocyte proliferation; immune response; positive regulation of T cell proliferation; cell cycle arrest
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 Research Articles on IL12A    1. The levels of EBI3 and IL-12p35 mRNAs in peripheral blood mononuclear cells in moderate or hyper-responders were significantly higher than those in non- or hypo-responders.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IL12A antibodyPathways associated with anti-IL12A antibody
 Reference Product  PubMed Publications
 IL12B antibody  >59 publications with IL12A and IL12B
 STAT4 antibody  >22 publications with IL12A and STAT4
 IL4 antibody  >21 publications with IL12A and IL4
 IL12RB2 antibody  >21 publications with IL12A and IL12RB2
 IFNG antibody  >17 publications with IL12A and IFNG
 IL12RB1 antibody  >15 publications with IL12A and IL12RB1
 STAT1 antibody  >9 publications with IL12A and STAT1
 IFNGR2 antibody  >6 publications with IL12A and IFNGR2
 STAT3 antibody  >6 publications with IL12A and STAT3
 TBX21 antibody  >3 publications with IL12A and TBX21
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 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
Diseases associated with anti-IL12A antibodyOrgans/Tissues associated with anti-IL12A antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >93 publications with IL12A and Inflammation
 Necrosis Antibodies  >56 publications with IL12A and Necrosis
 Disease Models, Animal Antibodies  >51 publications with IL12A and Disease Models, Animal
 Lung Diseases Antibodies  >25 publications with IL12A and Lung Diseases
 Liver Diseases Antibodies  >24 publications with IL12A and Liver Diseases
 Multiple Sclerosis Antibodies  >21 publications with IL12A and Multiple Sclerosis
 Neoplasms, Experimental Antibodies  >15 publications with IL12A and Neoplasms, Experimental
 Liver Cirrhosis, Biliary Antibodies  >12 publications with IL12A and Liver Cirrhosis, Biliary
 Fibrosis Antibodies  >8 publications with IL12A and Fibrosis
 Lung Neoplasms Antibodies  >7 publications with IL12A and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >36 publications with IL12A and Spleen
 Brain Antibodies  >20 publications with IL12A and Brain
 Intestine Antibodies  >15 publications with IL12A and Intestine
 Uterus Antibodies  >8 publications with IL12A and Uterus
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