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anti-IL21 antibody :: Rabbit anti-Human IL-21 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151281
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL-21 (IL21), Polyclonal Antibody

 Also Known As   

IL-21 Antibody

 Product Synonym Names    IL-21; Za11; IL-21; Interleukin-21; Za11; interleukin 21
 Product Gene Name   

anti-IL21 antibody

[Similar Products]
 Antibody/Peptide Pairs    IL-21 peptide (MBS152692) is used for blocking the activity of IL-21 antibody (MBS151281)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 615767
 3D Structure    ModBase 3D Structure for Q9HBE4
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    IL-21 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
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 Conjugate    Unconjugated
 Immunogen    IL-21 antibody was raised against a synthetic peptide corresponding to 15 amino acids near the center of human IL-21 precursor.
 Buffer    IL-21 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    IL-21 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-IL21 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IL21 antibody

   IL-21 Antibody: A novel cytokine was recently identified in human and mouse and designated IL-21, which has significant homology to IL-2, IL-4, and IL-15. The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL-21R forms a complex with the common cytokine receptor gamma chain, gammac, and mediates IL-21 signaling. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21 is expressed in activated T cells, and HL-60 and THP-1 cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.
 Applications Tested/Suitable for anti-IL21 antibody   

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)

 Application Notes for anti-IL21 antibody    IL-21 antibody can be used for detection of IL-21 by Western blot at 1 mug/mL. An approximately 18 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 2 mug/mL.
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 Western Blot (WB) of anti-IL21 antibody    Western blot analysis of IL-21 expression in HL-60 cell lysate in the absence (lane A) or presence of blocking peptide (lane B) with IL-21 antibody at 1 μg /ml.
anti-IL21 antibody Western Blot (WB) (WB) image
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 Immunocytochemistry (ICC) of anti-IL21 antibody    Immunocytochemistry of IL-21 in K562 cells with IL-21 antibody at 2 μg/mL.
anti-IL21 antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for IL21. It may not necessarily be applicable to this product.
 NCBI GI #    11141875
 NCBI GeneID    59067
 NCBI Accession #    NP_068575 [Other Products]
 NCBI GenBank Nucleotide #    NM_021803.3 [Other Products]
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 UniProt Primary Accession #    Q9HBE4 [Other Products]
 UniProt Secondary Accession #    A5J0L4 [Other Products]
 UniProt Related Accession #    Q9HBE4 [Other Products]
 Molecular Weight    18 kDa
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 NCBI Official Full Name    interleukin-21 isoform 1
 NCBI Official Synonym Full Names    interleukin 21
 NCBI Official Symbol    IL21 [Similar Products]
 NCBI Official Synonym Symbols   
Za11; IL-21; CVID11
[Similar Products]
 NCBI Protein Information    interleukin-21; interleukin-21 isoform
 UniProt Protein Name    Interleukin-21
 UniProt Synonym Protein Names   
Za11
 Protein Family    Interleukin
 UniProt Gene Name    IL21 [Similar Products]
 UniProt Synonym Gene Names    IL-21 [Similar Products]
 UniProt Entry Name    IL21_HUMAN
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 NCBI Summary for IL21    This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
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 UniProt Comments for IL21    IL21: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. Belongs to the IL-15/IL-21 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Cytokine; Secreted; Cell development/differentiation; Apoptosis

Chromosomal Location of Human Ortholog: 4q26-q27

Cellular Component: extracellular space

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor binding; interleukin-2 receptor binding; cytokine activity

Biological Process: positive regulation of interleukin-17 production; positive regulation of natural killer cell cytokine production; cell maturation; signal transduction; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of interleukin-10 production; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of natural killer cell differentiation; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of tissue remodeling; positive regulation of cell proliferation; positive regulation of B cell proliferation; immune response; positive regulation of T cell proliferation; positive regulation of interferon-gamma biosynthetic process; positive regulation of inflammatory response

Disease: Immunodeficiency, Common Variable, 11
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 Research Articles on IL21    1. IL-21 signals through the STAT-3 and STAT- 5b signaling pathway in the CIK cell pool.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IL21 antibodyPathways associated with anti-IL21 antibody
 Reference Product  PubMed Publications
 IL21R antibody  >372 publications with IL21 and IL21R
 STAT3 antibody  >117 publications with IL21 and STAT3
 IL15 antibody  >83 publications with IL21 and IL15
 IL4 antibody  >14 publications with IL21 and IL4
 IL13 antibody  >6 publications with IL21 and IL13
 IL9 antibody  >5 publications with IL21 and IL9
 IL7 antibody  >4 publications with IL21 and IL7
 NFATC2 antibody  >1 publications with IL21 and NFATC2
 TSLP antibody  >1 publications with IL21 and TSLP
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
Diseases associated with anti-IL21 antibodyOrgans/Tissues associated with anti-IL21 antibody
 Disease Name  Pubmed Publications
 Autoimmune Diseases Antibodies  >270 publications with IL21 and Autoimmune Diseases
 Inflammation Antibodies  >175 publications with IL21 and Inflammation
 Disease Models, Animal Antibodies  >119 publications with IL21 and Disease Models, Animal
 Lupus Erythematosus, Systemic Antibodies  >72 publications with IL21 and Lupus Erythematosus, Systemic
 Necrosis Antibodies  >64 publications with IL21 and Necrosis
 Liver Diseases Antibodies  >44 publications with IL21 and Liver Diseases
 Celiac Disease Antibodies  >32 publications with IL21 and Celiac Disease
 Hypersensitivity Antibodies  >29 publications with IL21 and Hypersensitivity
 Kidney Diseases Antibodies  >28 publications with IL21 and Kidney Diseases
 Heart Diseases Antibodies  >16 publications with IL21 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Uncharacterized Tissue Antibodies  >1 publications with IL21 and Uncharacterized Tissue
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