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anti-IL33 antibody :: Rabbit IL-33 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150331
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL-33 (IL33), Polyclonal Antibody

★Popular Item★
 Also Known As   

IL-33 Antibody

 Product Synonym Names    IL-33; DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26; NFHEV; Interleukin-33; Interleukin-1 family member 11; IL-33; interleukin 33
 Product Gene Name   

anti-IL33 antibody

[Similar Products]
 Antibody/Peptide Pairs    IL-33 peptide (MBS152579) is used for blocking the activity of IL-33 antibody (MBS150331)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608678
 3D Structure    ModBase 3D Structure for O95760
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    IL-33 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    IL-33 antibody was raised against a 19 amino acid synthetic peptide from near the center of human IL-33.
The immunogen is located within amino acids 150 - 200 of IL-33.
 Buffer    IL-33 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    IL-33 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-IL33 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IL33 antibody

   IL-33 Antibody: Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1α/beta, IL-1Ra and IL-18. Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling and IL-1R accessory protein (IL-1RAcP). Receptor binding of IL-33 activates NF-κB and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties.
 Applications Tested/Suitable for anti-IL33 antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry-Paraffin (IHC-P)

 Application Notes for anti-IL33 antibody    IL-33 antibody can be used for the detection of IL-33 by Western blot at 1 - 2 ug/mL. For immunofluorescence start at 20 ug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 ug/mL.
Optimal dilutions for each application to be determined by the researcher.

POSITIVE CONTROL: 1) Cat. No. MBS151677 - A20 Cell Lysate
2) Cat. No. MBS154265 - Human Lymphoid Tissue Tissue Slide
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 Western Blot (WB) of anti-IL33 antibody    Western blot analysis of IL-33 in human lymph node tissue lysate with IL-33 antibody at (A) 1 and (B) 2 μg/mL.
anti-IL33 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-IL33 antibody    Immunofluorescence of IL-33 in Human Lymph Node tissue with IL-33 antibody at 20 μg/mL.
anti-IL33 antibody Immunofluorescence (IF) image
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 Immunohistochemistry of anti-IL33 antibody    Immunohistochemistry of IL-33 in human lymph node tissue with IL-33 antibody at 2.5 ug/ml
anti-IL33 antibody Immunohistochemistry (IHC) image
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NCBI/Uniprot data below describe general gene information for IL33. It may not necessarily be applicable to this product.
 NCBI GI #    15559209
 NCBI GeneID    90865
 NCBI Accession #    NP_254274 [Other Products]
 NCBI GenBank Nucleotide #    NM_033439.3 [Other Products]
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 UniProt Primary Accession #    O95760 [Other Products]
 UniProt Secondary Accession #    Q2YEJ5; B2R8L1; B4DJ35; B4E1Q9; D3DRI5; E7EAX4 [Other Products]
 UniProt Related Accession #    O95760 [Other Products]
 Molecular Weight    Predicted: 30 kDa

Observed: 36 kDa
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 NCBI Official Full Name    interleukin-33 isoform 1
 NCBI Official Synonym Full Names    interleukin 33
 NCBI Official Symbol    IL33 [Similar Products]
 NCBI Official Synonym Symbols   
DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26
[Similar Products]
 NCBI Protein Information    interleukin-33; IL-33; IL-1F11; DVS27-related protein; interleukin-1 family member 11; nuclear factor for high endothelial venules; nuclear factor from high endothelial venules
 UniProt Protein Name    Interleukin-33
 UniProt Synonym Protein Names   
Interleukin-1 family member 11; IL-1F11; Nuclear factor from high endothelial venules; NF-HEV
 Protein Family    Interleukin
 UniProt Gene Name    IL33 [Similar Products]
 UniProt Synonym Gene Names    C9orf26; IL1F11; NFHEV; IL-33; IL-1F11; NF-HEV [Similar Products]
 UniProt Entry Name    IL33_HUMAN
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 NCBI Summary for IL33    IL33 (MIM 608678) is a member of the IL1 (see MIM 147760) family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL4; MIM 147780). IL33 is a ligand for IL33R (IL1RL1; MIM 601203), an IL1 family receptor that is selectively expressed on Th2 cells and mast cells (summary by Yagami et al., 2010 [PubMed 20926795]).[supplied by OMIM, Jan 2011]
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 UniProt Comments for IL33    IL33: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Belongs to the IL-1 family. Highly divergent. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 9p24.1

Cellular Component: extracellular space; transport vesicle; chromosome; nucleus

Molecular Function: protein binding; cytokine activity

Biological Process: positive regulation of T-helper 2 type immune response; negative regulation of T-helper 1 type immune response; T-helper 2 type immune response; transcription, DNA-dependent; positive regulation of interleukin-6 production; positive regulation of immunoglobulin secretion; negative regulation of leukocyte migration; positive regulation of interleukin-4 production; negative regulation of immunoglobulin secretion; negative regulation of interferon-gamma production; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of interleukin-13 production; positive regulation of interleukin-5 production; positive regulation of inflammatory response; positive regulation of macrophage activation
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 Research Articles on IL33    1. soluble ST2 and IL-33 were associated with mortality in patients with ST elevation myocardial infarction (STEMI) but not in patients with NSTEMI or stable angina.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IL33 antibodyPathways associated with anti-IL33 antibody
 Reference Product  PubMed Publications
 IL1RL1 antibody  >157 publications with IL33 and IL1RL1
 TSLP antibody  >19 publications with IL33 and TSLP
 CASP1 antibody  >17 publications with IL33 and CASP1
 IL18 antibody  >16 publications with IL33 and IL18
 IL25 antibody  >14 publications with IL33 and IL25
 IL18R1 antibody  >7 publications with IL33 and IL18R1
 VEGFA antibody  >3 publications with IL33 and VEGFA
 IL1B antibody  >2 publications with IL33 and IL1B
 CSF2 antibody  >1 publications with IL33 and CSF2
 Products by Pathway  Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
Diseases associated with anti-IL33 antibodyOrgans/Tissues associated with anti-IL33 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >186 publications with IL33 and Inflammation
 Asthma Antibodies  >86 publications with IL33 and Asthma
 Hypersensitivity, Immediate Antibodies  >82 publications with IL33 and Hypersensitivity, Immediate
 Lung Diseases Antibodies  >81 publications with IL33 and Lung Diseases
 Necrosis Antibodies  >55 publications with IL33 and Necrosis
 Cardiovascular Diseases Antibodies  >50 publications with IL33 and Cardiovascular Diseases
 Heart Diseases Antibodies  >30 publications with IL33 and Heart Diseases
 Fibrosis Antibodies  >20 publications with IL33 and Fibrosis
 Dermatitis, Atopic Antibodies  >18 publications with IL33 and Dermatitis, Atopic
 Disease Models, Animal Antibodies  >18 publications with IL33 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >53 publications with IL33 and Lung
 Skin Antibodies  >42 publications with IL33 and Skin
 Heart Antibodies  >42 publications with IL33 and Heart
 Vascular Antibodies  >33 publications with IL33 and Vascular
 Muscle Antibodies  >19 publications with IL33 and Muscle
 Intestine Antibodies  >17 publications with IL33 and Intestine
 Liver Antibodies  >16 publications with IL33 and Liver
 Brain Antibodies  >12 publications with IL33 and Brain
 Eye Antibodies  >9 publications with IL33 and Eye
 Connective Tissue Antibodies  >7 publications with IL33 and Connective Tissue
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