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anti-IL1B antibody :: Rabbit anti-Human IL1 beta Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175501
Western Blot (WB)
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL1 beta (IL1B), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-IL1 beta antibody

 Product Synonym Names    Interleukin-1 beta(IL-1 beta); interleukin 1, beta; Catabolin antibody; H1 antibody; Hematopoietin 1 antibody; IFN beta inducing factor antibody; IL 1 antibody; IL 1 beta antibody; IL 1B antibody; IL-1 beta antibody; IL1 BETA antibody; IL1B antibody; IL1B_HUMAN antibody; IL1F2 antibody; Interleukin 1 beta antibody; Interleukin 1 beta precursor antibody; Interleukin-1 beta antibody; LAF antibody; OAF antibody; Osteoclast activating factor antibody; OTTHUMP00000162031 antibody; Preinterleukin 1 beta antibody; Preinterleukin beta antibody; Pro interleukin 1 beta antibody
 Product Gene Name   

anti-IL1B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147720
 3D Structure    ModBase 3D Structure for P01584
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    No cross reactivity with other proteins.
 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of human IL1 beta (249-269aa FLGGTKGGQDITDFTMQFVSS).
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-IL1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IL1B antibody

   Description: Rabbit IgG polyclonal antibody for Interleukin-1 beta(IL1B) detection. Tested with WB in Human.
Background: Interleukin-1 beta(IL-1beta) also know as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene, which localizes to the long arm of chromosome 2 at position 2q13-2q21 between two fragile sites. Interleukin 1(IL-1) is a protein with several biological activities regulating host defense and immune responses. The human IL-1 family plays an important role in the pathogenesis of many diseases and functions as a key mediator of the host response to various infectious, inflammatory, and immunologic challenges.
 Applications Tested/Suitable for anti-IL1B antibody   

Western Blot (WB)

 Application Notes for anti-IL1B antibody    Western Blot:
Concentration: 0.1-0.5ug/ml
Tested Species: Hu
Predicted Species: -
Antigen Retrieval: -

Tested Species: In-house tested species with positive results.
Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested
Optimal dilutions should be determined by end users.
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 Western Blot (WB) of anti-IL1B antibody    Anti-IL-1 beta antibody, MBS175501, Western blotting
Lane 1: Recombinant Human IL-1 beta Protein 20ng
Lane 2: Recombinant Human IL-1 beta Protein 10ng
anti-IL1B antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for IL1B. It may not necessarily be applicable to this product.
 NCBI GI #    62906858
 NCBI GeneID    3553
 NCBI Accession #    P01584.2 [Other Products]
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 UniProt Primary Accession #    P01584 [Other Products]
 UniProt Secondary Accession #    Q53X59; Q53XX2; Q7M4S7; Q7RU01; Q96HE5; Q9UCT6 [Other Products]
 UniProt Related Accession #    P01584 [Other Products]
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 NCBI Official Full Name    Interleukin-1 beta
 NCBI Official Synonym Full Names    interleukin 1, beta
 NCBI Official Symbol    IL1B [Similar Products]
 NCBI Official Synonym Symbols   
IL-1; IL1F2; IL1-BETA
[Similar Products]
 NCBI Protein Information    interleukin-1 beta; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta
 UniProt Protein Name    Interleukin-1 beta
 UniProt Synonym Protein Names   
Catabolin
 Protein Family    Interleukin
 UniProt Gene Name    IL1B [Similar Products]
 UniProt Synonym Gene Names    IL1F2; IL-1 beta [Similar Products]
 UniProt Entry Name    IL1B_HUMAN
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 NCBI Summary for IL1B    The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IL1B    IL1B: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Monomer. Belongs to the IL-1 family.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 2q14

Cellular Component: extracellular space; extracellular region; cytosol; secretory granule

Molecular Function: protein domain specific binding; interleukin-1 receptor binding; cytokine activity

Biological Process: positive regulation of granulocyte macrophage colony-stimulating factor production; negative regulation of MAP kinase activity; positive regulation of nitric oxide biosynthetic process; activation of MAPK activity; positive regulation of transcription, DNA-dependent; positive regulation of interleukin-2 biosynthetic process; germ cell programmed cell death; negative regulation of insulin receptor signaling pathway; positive regulation of NF-kappaB import into nucleus; positive regulation of lipid catabolic process; fever; positive regulation of membrane protein ectodomain proteolysis; response to carbohydrate stimulus; activation of NF-kappaB transcription factor; cell-cell signaling; positive regulation of phagocytosis; positive regulation of T cell mediated immunity; positive regulation of T cell proliferation; neutrophil chemotaxis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of heterotypic cell-cell adhesion; positive regulation of mitosis; smooth muscle adaptation; interleukin-1 beta production; positive regulation of interleukin-6 production; positive regulation of angiogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; negative regulation of lipid metabolic process; sequestering of triacylglycerol; positive regulation of histone phosphorylation; apoptosis; positive regulation of interleukin-6 biosynthetic process; positive regulation of JNK cascade; signal transduction; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of protein export from nucleus; positive regulation of interleukin-8 production; negative regulation of cell proliferation; negative regulation of lipid catabolic process; hyaluronan biosynthetic process; protein kinase B signaling cascade; lipopolysaccharide-mediated signaling pathway; regulation of I-kappaB kinase/NF-kappaB cascade; inflammatory response; cytokine and chemokine mediated signaling pathway; MAPKKK cascade; response to ATP; positive regulation of interferon-gamma production; positive regulation of chemokine biosynthetic process; positive regulation of prostaglandin secretion; positive regulation of fever; immune response; positive regulation of histone acetylation; positive regulation of protein amino acid phosphorylation; regulation of insulin secretion; embryo implantation

Disease: Gastric Cancer, Hereditary Diffuse
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 Research Articles on IL1B    1. THP-1 monocyte-secreted IL-1beta/IL-18 promotes vascular smooth muscle cell proliferation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IL1B antibodyPathways associated with anti-IL1B antibody
 Reference Product  PubMed Publications
 IL6 antibody  >260 publications with IL1B and IL6
 CASP1 antibody  >57 publications with IL1B and CASP1
 IL1R1 antibody  >36 publications with IL1B and IL1R1
 IL18 antibody  >29 publications with IL1B and IL18
 NOS2 antibody  >25 publications with IL1B and NOS2
 NFKB1 antibody  >21 publications with IL1B and NFKB1
 MYD88 antibody  >20 publications with IL1B and MYD88
 IL1R2 antibody  >12 publications with IL1B and IL1R2
 IL23A antibody  >5 publications with IL1B and IL23A
 IL1RAP antibody  >3 publications with IL1B and IL1RAP
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 Cellular Roles Of Anthrax Toxin Pathway antibodies  Cellular Roles Of Anthrax Toxin Pathway Diagram
Diseases associated with anti-IL1B antibodyOrgans/Tissues associated with anti-IL1B antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >365 publications with IL1B and Inflammation
 Necrosis Antibodies  >231 publications with IL1B and Necrosis
 Skin Diseases Antibodies  >50 publications with IL1B and Skin Diseases
 Stomach Neoplasms Antibodies  >41 publications with IL1B and Stomach Neoplasms
 Arthritis, Rheumatoid Antibodies  >26 publications with IL1B and Arthritis, Rheumatoid
 Adenocarcinoma Antibodies  >23 publications with IL1B and Adenocarcinoma
 Hypersensitivity Antibodies  >22 publications with IL1B and Hypersensitivity
 Asthma Antibodies  >21 publications with IL1B and Asthma
 Myocardial Ischemia Antibodies  >19 publications with IL1B and Myocardial Ischemia
 Lung Neoplasms Antibodies  >16 publications with IL1B and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >303 publications with IL1B and Blood
 Lung Antibodies  >74 publications with IL1B and Lung
 Vascular Antibodies  >59 publications with IL1B and Vascular
 Uterus Antibodies  >53 publications with IL1B and Uterus
 Stomach Antibodies  >48 publications with IL1B and Stomach
 Brain Antibodies  >43 publications with IL1B and Brain
 Liver Antibodies  >38 publications with IL1B and Liver
 Skin Antibodies  >37 publications with IL1B and Skin
 Bone Marrow Antibodies  >29 publications with IL1B and Bone Marrow
 Muscle Antibodies  >23 publications with IL1B and Muscle
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