NP_002179.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 16 kDa Predicted: 16 kDa
NCBI Official Full Name
interleukin-13 isoform 1
NCBI Official Synonym Full Names
interleukin 13
NCBI Official Synonym Symbols
NCBI Protein Information
interleukin-13
UniProt Protein Name
Interleukin-13
UniProt Synonym Gene Names
NCBI Summary for IL13
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
UniProt Comments for IL13
Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages ().
Research Articles on IL13
Precautions
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Products associated with anti-IL13 antibody
Pathways associated with anti-IL13 antibody
Diseases associated with anti-IL13 antibody
Organs/Tissues associated with anti-IL13 antibody
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