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anti-IL17RC antibody :: Rabbit IL17RC Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS541867
Unit / Price
0.1 mg Affinity-Purified  /  $390 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL17RC, Polyclonal Antibody

 Also Known As   

IL17RC Antibody

 Product Synonym Names    CX2; Cytokine CX2; IL 17C; IL 21; Interleukin-17C; MGC126884; MGC138401 antibody
 Product Gene Name   

anti-IL17RC antibody

[Similar Products]
 Matching Pairs    Antibody: IL17C (MBS541867)
Positive Control: IL17C (MBS542867)
 Antibody/Peptide Pairs    IL17C peptide (MBS543841) is used for blocking the activity of IL17C antibody (MBS541867)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    610925
 3D Structure    ModBase 3D Structure for Q8NAC3
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Monkey
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 Form/Format    Affinity Purified Immunoglobulins
 Concentration    0.78 mg/ml IgG in antibody stabilization buffer (lot specific)
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 Immunogen    Synthetic peptide corresponding to IL17RC protein common to C1, C2, C5, C8, C9, C11, C12 isoforms.
 Expression    Expressed in brain, cartilage, colon, heart, intestine, kidney, liver, lung, muscle, placenta, and prostate. Low expression in thymus and leukocytes. Expressed (at protein level) in prostate and prostate cancer, skeletal muscle, kidney and placenta.
 Molecular Function    interleukin-17 receptor activity
 Subcellular Location    Cell membrane, Single-pass type 1 membrane protein (Note: soluble isoforms may be produced)
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 Preparation and Storage    -20 degree C for long term storage
 Other Notes    Small volumes of anti-IL17RC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-IL17RC antibody

   Affinity Purified Pan Interleukin-17 receptor C Antibody
 Product Categories/Family for anti-IL17RC antibody    Primary Antibodies; Immunology; Innate Immunity; Cytokines; Interleukins; IL17RC Antibody
 Applications Tested/Suitable for anti-IL17RC antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

 Application Notes for anti-IL17RC antibody    Dot Blot: 1:10,000
ELISA: 1:10,000
Immunohistochemistry: 1:100
Immunoprecipitation: 1:200
Western Blot: 1:500
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 Immunohistochemistry (IHC) of anti-IL17RC antibody    anti-IL17RC antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-IL17RC antibody    anti-IL17RC antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for IL17RC. It may not necessarily be applicable to this product.
 NCBI GI #    24430197
 NCBI GeneID    84818
 NCBI Accession #    NP_703191.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_153461.3 [Other Products]
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 UniProt Primary Accession #    Q8NAC3 [Other Products]
 UniProt Secondary Accession #    Q6UVY3; Q6UWD4; Q8NFS1; Q9BR97; A8BWC1; A8BWC9; A8BWD5; E9PHG1; E9PHJ6 [Other Products]
 UniProt Related Accession #    Q8NAC3 [Other Products]
 Molecular Weight    75,432 Da
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 NCBI Official Full Name    interleukin-17 receptor C isoform 2
 NCBI Official Synonym Full Names    interleukin 17 receptor C
 NCBI Official Symbol    IL17RC [Similar Products]
 NCBI Official Synonym Symbols   
CANDF9; IL17RL; IL17-RL
[Similar Products]
 NCBI Protein Information    interleukin-17 receptor C
 UniProt Protein Name    Interleukin-17 receptor C
 UniProt Synonym Protein Names   
Interleukin-17 receptor homolog; IL17Rhom; Interleukin-17 receptor-like protein; IL-17RL; ZcytoR14
 Protein Family    Interleukin-17 receptor
 UniProt Gene Name    IL17RC [Similar Products]
 UniProt Synonym Gene Names    IL-17 receptor C; IL-17RC; IL17Rhom; IL-17RL [Similar Products]
 UniProt Entry Name    I17RC_HUMAN
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 NCBI Summary for IL17RC    This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]
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 UniProt Comments for IL17RC    IL17RC: a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p25.3|3p25.3-p24.1

Cellular Component: cell surface; integral to plasma membrane; plasma membrane

Molecular Function: interleukin-17 receptor activity; receptor binding

Biological Process: cytokine and chemokine mediated signaling pathway; defense response to fungus

Disease: Candidiasis, Familial, 9
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 Research Articles on IL17RC    1. human IL-17RC is essential for mucocutaneous immunity to C. albicans but is otherwise largely redundant.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-IL17RC antibodyDiseases associated with anti-IL17RC antibody
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 IL17 Signaling Pathway antibodies  IL17 Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-17 Signaling Pathway antibodies  Interleukin-17 Signaling Pathway Diagram
 Signaling By Interleukins Pathway antibodies  Signaling By Interleukins Pathway Diagram
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >9 publications with IL17RC and Necrosis
 Immune System Diseases Antibodies  >9 publications with IL17RC and Immune System Diseases
 Autoimmune Diseases Antibodies  >8 publications with IL17RC and Autoimmune Diseases
 Genital Diseases, Male Antibodies  >5 publications with IL17RC and Genital Diseases, Male
 Prostatic Diseases Antibodies  >4 publications with IL17RC and Prostatic Diseases
 Respiratory Tract Diseases Antibodies  >4 publications with IL17RC and Respiratory Tract Diseases
 Prostatic Neoplasms Antibodies  >4 publications with IL17RC and Prostatic Neoplasms
 Nervous System Diseases Antibodies  >3 publications with IL17RC and Nervous System Diseases
 Death Antibodies  >3 publications with IL17RC and Death
 Weight Loss Antibodies  >2 publications with IL17RC and Weight Loss
Organs/Tissues associated with anti-IL17RC antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with IL17RC and Blood
 Eye Antibodies  >4 publications with IL17RC and Eye
 Intestine Antibodies  >4 publications with IL17RC and Intestine
 Vascular Antibodies  >4 publications with IL17RC and Vascular
 Prostate Antibodies  >4 publications with IL17RC and Prostate
 Brain Antibodies  >3 publications with IL17RC and Brain
 Kidney Antibodies  >2 publications with IL17RC and Kidney
 Bone Marrow Antibodies  >2 publications with IL17RC and Bone Marrow
 Heart Antibodies  >2 publications with IL17RC and Heart
 Skin Antibodies  >2 publications with IL17RC and Skin
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