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anti-IL18 antibody :: Rabbit anti-Human IL18 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS176767
Unit / Price
0.1 mg  /  $280 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL18, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-IL18 antibody

 Product Synonym Names    Interleukin-18; interleukin 18 (interferon-gamma-inducing factor); Iboctadekin antibody; IFN gamma inducing factor antibody; IFN-gamma-inducing factor antibody; IGIF antibody; IL 1 gamma antibody; IL 18 antibody; IL 1g antibody; IL-1 gamma antibody; IL-18 antibody; IL1 gamma antibody; IL18 antibody; IL18 protein antibody; IL1F4 antibody; IL1g antibody; IL1gamma antibody; ILIF4 antibody; Interferon gamma inducing factor antibody; Interferon gamma-inducing factor antibody; Interleukin 1 gamma antibody; Interleukin 18 antibody; Interleukin-1 gamma antibody; Interleukin-18 antibody; Interleukin18 antibody; MGC12320 antibody
 Product Gene Name   

anti-IL18 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600953
 3D Structure    ModBase 3D Structure for Q14116
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    No cross reactivity with other proteins.
 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    E Coli-derived human IL18 recombinant protein (Position: Y37-D193).
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-IL18 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IL18 antibody

   Description: Rabbit IgG polyclonal antibody for Interleukin-18(IL18) detection. Tested with WB, IHC-P in Human.
Background: Interleukin-18 also known as IL18 is a protein which in humans is encoded by the IL18 gene. The protein encoded by this gene is a proinflammatory cytokine.IL-18 is a cytokine produced by macrophages and other cells that belongs to the IL-1 superfamily. IL-18 works by binding to the interleukin-18 receptor, and together with IL-12 it induces cell-mediated immunity following infection with microbial products like lipopolysaccharide (LPS). After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-gamma (IFN-gamma) or type II interferon that plays an important role in activating the macrophages or other cells.The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production in B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci.
 Applications Tested/Suitable for anti-IL18 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

 Application Notes for anti-IL18 antibody    Western Blot:
Concentration: 0.1-0.5ug/ml
Tested Species: Hu

Immunohistochemistry (Paraffin-embedded Section):
Concentration: 0.5-1ug/ml
Tested Species: Hu
Antigen Retrieval: By Heat
Immunocytochemistry:
Concentration: 0.58-1ug/ml
Tested Species: Hu

WB: The detection limit for IL18 is approximately 0.25ng/lane under reducing conditions.
By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Other applications have not been tested.
Optimal dilutions shoudl be determined by end users.
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 Immunohistochemistry (IHC) of anti-IL18 antibody    Anti-IL-18 Picoband antibody, MBS176767-1.JPG
IHC(P): Human Tonsil Tissue
anti-IL18 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-IL18 antibody    Anti-IL-18 Picoband antibody, MBS176767-2.jpg
All lanes: Anti-IL18 (MBS176767) at 0.5ug/ml
WB: HELA Whole Cell Lysate at 40ug
Predicted bind size: 22KD
Observed bind size: 22KD
anti-IL18 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for IL18. It may not necessarily be applicable to this product.
 NCBI GI #    3219817
 NCBI GeneID    3606
 NCBI Accession #    Q14116.1 [Other Products]
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 UniProt Primary Accession #    Q14116 [Other Products]
 UniProt Secondary Accession #    O75599; Q6FGY3; Q6WWJ7 [Other Products]
 UniProt Related Accession #    Q14116 [Other Products]
 Molecular Weight    21,896 Da
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 NCBI Official Full Name    Interleukin-18
 NCBI Official Synonym Full Names    interleukin 18
 NCBI Official Symbol    IL18 [Similar Products]
 NCBI Official Synonym Symbols   
IGIF; IL-18; IL-1g; IL1F4
[Similar Products]
 NCBI Protein Information    interleukin-18; IL-1 gamma; iboctadekin; interleukin-1 gamma; IFN-gamma-inducing factor; interleukin 18 (interferon-gamma-inducing factor)
 UniProt Protein Name    Interleukin-18
 UniProt Synonym Protein Names   
Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma
 Protein Family    Interleukin
 UniProt Gene Name    IL18 [Similar Products]
 UniProt Synonym Gene Names    IGIF; IL1F4; IL-18; IFN-gamma-inducing factor; IL-1 gamma [Similar Products]
 UniProt Entry Name    IL18_HUMAN
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 NCBI Summary for IL18    The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
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 UniProt Comments for IL18    IL18: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. Belongs to the IL-1 family.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 11q22.2-q22.3

Cellular Component: extracellular space; extracellular region; cytosol

Molecular Function: protein binding; cytokine activity

Biological Process: positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of interleukin-17 production; regulation of cell adhesion; T-helper 1 type immune response; positive regulation of natural killer cell proliferation; interleukin-2 biosynthetic process; T-helper 2 type immune response; positive regulation of NK T cell proliferation; MAPKKK cascade; natural killer cell activation; interleukin-13 biosynthetic process; positive regulation of NF-kappaB import into nucleus; positive regulation of activated T cell proliferation; sleep; chemokine biosynthetic process; positive regulation of tissue remodeling; positive regulation of interferon-gamma production; cell-cell signaling; lipopolysaccharide-mediated signaling pathway; interferon-gamma biosynthetic process; granulocyte macrophage colony-stimulating factor biosynthetic process; immune response; angiogenesis; inflammatory response; negative regulation of myoblast differentiation; positive regulation of inflammatory response
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 Research Articles on IL18    1. THP-1 monocyte-secreted IL-1beta/IL-18 promotes vascular smooth muscle cell proliferation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IL18 antibodyPathways associated with anti-IL18 antibody
 Reference Product  PubMed Publications
 CASP1 antibody  >519 publications with IL18 and CASP1
 IL10 antibody  >296 publications with IL18 and IL10
 IL18R1 antibody  >219 publications with IL18 and IL18R1
 IL13 antibody  >90 publications with IL18 and IL13
 IL6 antibody  >72 publications with IL18 and IL6
 IL18RAP antibody  >35 publications with IL18 and IL18RAP
 IL1B antibody  >29 publications with IL18 and IL1B
 IFNG antibody  >23 publications with IL18 and IFNG
 IL18BP antibody  >19 publications with IL18 and IL18BP
 CCR5 antibody  >18 publications with IL18 and CCR5
 Products by Pathway  Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Cellular Roles Of Anthrax Toxin Pathway antibodies  Cellular Roles Of Anthrax Toxin Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Hypertrophy Model Pathway antibodies  Hypertrophy Model Pathway Diagram
Diseases associated with anti-IL18 antibodyOrgans/Tissues associated with anti-IL18 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1202 publications with IL18 and Inflammation
 Necrosis Antibodies  >796 publications with IL18 and Necrosis
 Cardiovascular Diseases Antibodies  >434 publications with IL18 and Cardiovascular Diseases
 Lung Diseases Antibodies  >328 publications with IL18 and Lung Diseases
 Kidney Diseases Antibodies  >306 publications with IL18 and Kidney Diseases
 Liver Diseases Antibodies  >238 publications with IL18 and Liver Diseases
 Arthritis, Rheumatoid Antibodies  >221 publications with IL18 and Arthritis, Rheumatoid
 Heart Diseases Antibodies  >204 publications with IL18 and Heart Diseases
 Hypersensitivity, Immediate Antibodies  >188 publications with IL18 and Hypersensitivity, Immediate
 Neoplasms, Experimental Antibodies  >123 publications with IL18 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >406 publications with IL18 and Liver
 Lung Antibodies  >316 publications with IL18 and Lung
 Heart Antibodies  >217 publications with IL18 and Heart
 Bone Antibodies  >215 publications with IL18 and Bone
 Brain Antibodies  >212 publications with IL18 and Brain
 Skin Antibodies  >212 publications with IL18 and Skin
 Bone Marrow Antibodies  >144 publications with IL18 and Bone Marrow
 Muscle Antibodies  >133 publications with IL18 and Muscle
 Connective Tissue Antibodies  >74 publications with IL18 and Connective Tissue
 Uterus Antibodies  >40 publications with IL18 and Uterus
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